Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Condensin complex subunit 1

Gene

Ncapd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.By similarity

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • histone binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin complex subunit 1
Alternative name(s):
Chromosome condensation-related SMC-associated protein 1
Chromosome-associated protein D2
Short name:
mCAP-D2
Non-SMC condensin I complex subunit D2
XCAP-D2 homolog
Gene namesi
Name:Ncapd2
Synonyms:Capd2, Cnap1, Kiaa0159
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915548 Ncapd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000950361 – 1392Condensin complex subunit 1Add BLAST1392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1
Modified residuei575PhosphoserineBy similarity1
Modified residuei1300PhosphoserineCombined sources1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1320PhosphoserineCombined sources1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1329PhosphothreonineCombined sources1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1361PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1367PhosphoserineBy similarity1
Modified residuei1375Phosphothreonine; by CDK1By similarity1
Modified residuei1380Phosphothreonine; by CDK1By similarity1
Modified residuei1386PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2Z4
PaxDbiQ8K2Z4
PeptideAtlasiQ8K2Z4
PRIDEiQ8K2Z4

PTM databases

iPTMnetiQ8K2Z4
PhosphoSitePlusiQ8K2Z4

Expressioni

Gene expression databases

CleanExiMM_NCAPD2

Interactioni

Subunit structurei

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212791, 2 interactors
ComplexPortaliCPX-980 Condensin I complex
IntActiQ8K2Z4, 1 interactor
STRINGi10090.ENSMUSP00000042260

Structurei

3D structure databases

ProteinModelPortaliQ8K2Z4
SMRiQ8K2Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 593Interaction with SMC2 and SMC4By similarityAdd BLAST593

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1332 – 1353Bipartite nuclear localization signalBy similarityAdd BLAST22

Domaini

The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region (By similarity).By similarity

Sequence similaritiesi

Belongs to the CND1 (condensin subunit 1) family.Curated

Phylogenomic databases

eggNOGiKOG0414 Eukaryota
COG5098 LUCA
HOVERGENiHBG038048
InParanoidiQ8K2Z4
KOiK06677
PhylomeDBiQ8K2Z4
TreeFamiTF105712

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K2Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPHNFEFHL PLSPEELLKS GGVNQYVVRE VLPVKHLSSQ LRAFQSAFRA
60 70 80 90 100
QGPLAILEHF DTVYSILHHF RSIEPGLKED TLEFLKKVVS RHSQELSSIL
110 120 130 140 150
DDAALSGSDR SAHLNALKMN CYALIRLLES FENMTSQTSL IDLDIGGKGK
160 170 180 190 200
RARAKATLGF DWEEERQPVL QLLTQLLQLD IRHLWNHSAI EEEFVSLVTG
210 220 230 240 250
CCYRLLENPT ISHQKNRSTK EAIAHLLGVA LVRYNHMLSA TVKIIQMLQH
260 270 280 290 300
FEHLPPVLVT AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDTAGAKGF
310 320 330 340 350
AAFLTELAER IPAVLMANMC ILLDHLDGEN YMMRNAVLAA IAEMVLQVLN
360 370 380 390 400
GDQLEESARE TRDQFLDILQ AHGHDVNSFV RSRVLQLFAR IVQQKALPLT
410 420 430 440 450
RFQAVVALAV GRLADKSVLV CKNAIQLLAS FLANNPFSCK LSDIDLAGPL
460 470 480 490 500
QKEIQKLQEM RAQRRSAAAT AALDPEEEWD AMLPELKSTL QQLLKLPQEE
510 520 530 540 550
GDHQIADAET AEEVKGRIRQ LLAKASYKQA IVLTREATSH FQESEPFSHT
560 570 580 590 600
EPEENSFLNL LGLIFKGPEA STQDSHGDTD PGLTGSKDSP SVPEPEGSQS
610 620 630 640 650
NDELVKQEML VQYLQDAYGF SQKITEAIGI ISKMMYENTT TVVQEVIEFF
660 670 680 690 700
VMVFQFGVPQ ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL YLNPKGDSAR
710 720 730 740 750
AKAQTLIHNL SLLLVDASVG TIQCLEEILC EFVQKDEVKP AVIQLLWERA
760 770 780 790 800
TEKVPSSPLE RCSSVMLLGM MARGKPEIVG SNLDALVRVG LDEKSPQDYR
810 820 830 840 850
LAQQVCLAIA NISDRRKPSL GERHPPFRLP QEHRLFERLQ DMVTKGFAHP
860 870 880 890 900
DPLWIPFKEV AVTLTYQLAE SPDVLCAQML QGCAKQVLEK LEKNATEADP
910 920 930 940 950
KETAPRLPTF LLMNLLSLAG DVALQQLVHL EQAVSGELGR RRVLREEQEH
960 970 980 990 1000
RAKEPKEKTA SSETTMEEEL GLVGGATADD TEAELIRSIC EKELLDGNQV
1010 1020 1030 1040 1050
LAAFVPLLLK VCNNPGLYSN PELCAAASLA LGKFCMISAP FCDSQLRLLF
1060 1070 1080 1090 1100
TMLEKSSLPT VRSNLMVATG DLAIRFPNLV DPWTPHLYAR LRDPAQQVRK
1110 1120 1130 1140 1150
TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PVPQIAALAK NFFNELSHKG
1160 1170 1180 1190 1200
NAIYNLLPDI ISRLSDPEGG VEEEPFHTIM KQLLSYITKD KQTESLVEKL
1210 1220 1230 1240 1250
CQRFRTARTE RQYRDLAYCM SQLPLTERGL QKMLDNFECF GDKLLDESVF
1260 1270 1280 1290 1300
SAFLSIVGKL RRGAKPEGKA IIDEFEQKLR ACHTRGMDGI EEFETGQGGS
1310 1320 1330 1340 1350
QRALSAKKPS AVSRLQPLTS VDSDNDFVTP KPRRTKPGRP QTQQRKKSQR
1360 1370 1380 1390
KAKVVFLSDE SSEDELSAEM TEEETPKRTT PIRRASGRRH RS
Length:1,392
Mass (Da):155,665
Last modified:April 23, 2003 - v2
Checksum:i192E117CC7172A87
GO
Isoform 2 (identifier: Q8K2Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1382-1392: IRRASGRRHRS → TLVEVLVVCGFNMEMAFALRSFS

Note: No experimental confirmation available.
Show »
Length:1,404
Mass (Da):156,878
Checksum:i717D40C6778889AF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0H7A0A0R4J0H7_MOUSE
Condensin complex subunit 1
Ncapd2
1,392Annotation score:
A0A087WNQ1A0A087WNQ1_MOUSE
Condensin complex subunit 1
Ncapd2
162Annotation score:
A0A087WRK6A0A087WRK6_MOUSE
Condensin complex subunit 1
Ncapd2
94Annotation score:

Sequence cautioni

The sequence AAH06673 differs from that shown. Contaminating sequence.Curated
The sequence BAC97878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BC025460 differs from that shown. Reason: Erroneous termination at position 1245. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti574D → G in AAH26982 (PubMed:15489334).Curated1
Sequence conflicti1256I → V in AAH26982 (PubMed:15489334).Curated1
Sequence conflicti1256I → V in BAB31633 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0072461382 – 1392IRRASGRRHRS → TLVEVLVVCGFNMEMAFALR SFS in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129068 mRNA Translation: BAC97878.1 Different initiation.
BC006673 mRNA Translation: AAH06673.1 Sequence problems.
BC008592 mRNA Translation: AAH08592.1
BC025460 mRNA No translation available.
BC026982 mRNA Translation: AAH26982.1
BC029133 mRNA Translation: AAH29133.1
AK011352 mRNA Translation: BAB27560.1
AK019259 mRNA Translation: BAB31633.1
CCDSiCCDS39636.1 [Q8K2Z4-1]
RefSeqiNP_666283.1, NM_146171.1
XP_006506594.1, XM_006506531.3
UniGeneiMm.257590

Genome annotation databases

GeneIDi68298
KEGGimmu:68298
UCSCiuc009dtt.1 mouse [Q8K2Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129068 mRNA Translation: BAC97878.1 Different initiation.
BC006673 mRNA Translation: AAH06673.1 Sequence problems.
BC008592 mRNA Translation: AAH08592.1
BC025460 mRNA No translation available.
BC026982 mRNA Translation: AAH26982.1
BC029133 mRNA Translation: AAH29133.1
AK011352 mRNA Translation: BAB27560.1
AK019259 mRNA Translation: BAB31633.1
CCDSiCCDS39636.1 [Q8K2Z4-1]
RefSeqiNP_666283.1, NM_146171.1
XP_006506594.1, XM_006506531.3
UniGeneiMm.257590

3D structure databases

ProteinModelPortaliQ8K2Z4
SMRiQ8K2Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212791, 2 interactors
ComplexPortaliCPX-980 Condensin I complex
IntActiQ8K2Z4, 1 interactor
STRINGi10090.ENSMUSP00000042260

PTM databases

iPTMnetiQ8K2Z4
PhosphoSitePlusiQ8K2Z4

Proteomic databases

EPDiQ8K2Z4
PaxDbiQ8K2Z4
PeptideAtlasiQ8K2Z4
PRIDEiQ8K2Z4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi68298
KEGGimmu:68298
UCSCiuc009dtt.1 mouse [Q8K2Z4-1]

Organism-specific databases

CTDi9918
MGIiMGI:1915548 Ncapd2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0414 Eukaryota
COG5098 LUCA
HOVERGENiHBG038048
InParanoidiQ8K2Z4
KOiK06677
PhylomeDBiQ8K2Z4
TreeFamiTF105712

Miscellaneous databases

ChiTaRSiNcapd2 mouse
PROiPR:Q8K2Z4
SOURCEiSearch...

Gene expression databases

CleanExiMM_NCAPD2

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR007673 Condensin_cplx_su1
IPR024324 Condensin_cplx_su1_N
PANTHERiPTHR14222 PTHR14222, 1 hit
PTHR14222:SF2 PTHR14222:SF2, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PF12922 Cnd1_N, 1 hit
PIRSFiPIRSF017127 Condensin_D2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCND1_MOUSE
AccessioniPrimary (citable) accession number: Q8K2Z4
Secondary accession number(s): Q6ZQI1
, Q8R0F2, Q8R3H0, Q922B7, Q923A3, Q9CS25, Q9CT32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: November 7, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again