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Protein

Importin-11

Gene

Ipo11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein transporter activity Source: MGI
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • protein import into nucleus Source: GO_Central
  • ribosomal protein import into nucleus Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-11
Short name:
Imp11
Alternative name(s):
Ran-binding protein 11
Short name:
RanBP11
Gene namesi
Name:Ipo11
Synonyms:Ranbp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2442377 Ipo11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207571 – 975Importin-11Add BLAST975

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K2V6
PaxDbiQ8K2V6
PeptideAtlasiQ8K2V6
PRIDEiQ8K2V6

PTM databases

iPTMnetiQ8K2V6
PhosphoSitePlusiQ8K2V6
SwissPalmiQ8K2V6

Expressioni

Gene expression databases

BgeeiENSMUSG00000042590 Expressed in 278 organ(s), highest expression level in blood
CleanExiMM_IPO11
ExpressionAtlasiQ8K2V6 baseline and differential
GenevisibleiQ8K2V6 MM

Interactioni

Subunit structurei

Interacts with UBE2E3 and RPL12.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079667

Structurei

3D structure databases

ProteinModelPortaliQ8K2V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST73
Repeati123 – 160HEAT 1Add BLAST38
Repeati283 – 317HEAT 2Add BLAST35
Repeati318 – 356HEAT 3Add BLAST39
Repeati422 – 459HEAT 4Add BLAST38
Repeati473 – 509HEAT 5Add BLAST37
Repeati511 – 548HEAT 6Add BLAST38
Repeati555 – 593HEAT 7Add BLAST39
Repeati600 – 636HEAT 8Add BLAST37
Repeati640 – 677HEAT 9Add BLAST38
Repeati683 – 720HEAT 10Add BLAST38
Repeati731 – 773HEAT 11Add BLAST43
Repeati819 – 849HEAT 12Add BLAST31
Repeati850 – 887HEAT 13Add BLAST38
Repeati957 – 974HEAT 14Add BLAST18

Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1993 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00390000014071
HOGENOMiHOG000008140
HOVERGENiHBG061387
InParanoidiQ8K2V6
OMAiYVFHEGT
OrthoDBiEOG091G01EL
PhylomeDBiQ8K2V6
TreeFamiTF324336

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K2V6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLNSASSVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT
60 70 80 90 100
NHTLDINVRW LAVLYFKHGI DRYWRRVAPH ALSEEEKSTL RAGLITNFNE
110 120 130 140 150
PINQIATQIA VLIAKVARLD CPRQWPELIP TLVESVKVQD DLRQHRALLT
160 170 180 190 200
FYHVTKTLAS KRLAADRKLF YDLASGIYNF ACSLWNHHTD TFLQHVSSGN
210 220 230 240 250
EAAVLSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH GIFERLKQFL
260 270 280 290 300
ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPISFTP LIQRSLEFSV
310 320 330 340 350
SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH
360 370 380 390 400
KIKMAFFTYP TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS
410 420 430 440 450
WKYSLRPCTE VLFIDIFHEY NQTLTPVLLE MMQTLEGPTN VEDMNALLIK
460 470 480 490 500
DAVYNAVGLA AFELFDSVDF DQWFKTQLLP ELQVSHNRYK PLRRRVIWLI
510 520 530 540 550
GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK LTVDDFEFRT
560 570 580 590 600
DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNVQIRPYVG
610 620 630 640 650
CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ
660 670 680 690 700
LSTDVSQPPH VYLLEDGLEL WLVTLENSPC VTPELLRIFQ NMSPLLELSS
710 720 730 740 750
ENLRTCFKII NGYIFLSSTE FLQTYAAGLC QSFYELLPEI TTEGQVQVLK
760 770 780 790 800
VVENALKVNP VLGPQMFQRI LPCVFRGVIE GERYPVVMSI YLAVMGRVLL
810 820 830 840 850
QNTSFFSSLL NEMGHEFNQE MDQLLGNVIE MWVDRMDNIT QPERKKLSAL
860 870 880 890 900
ALLSLLPSDN SVIQDKFCGI INISVEALHD VMTEDPETRT YKDCMLMSQH
910 920 930 940 950
EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEILGE
960 970
QGFQSLMETV DTEIVTQLQE FLQGF
Length:975
Mass (Da):112,416
Last modified:October 1, 2002 - v1
Checksum:i3DEA79E8028C483D
GO
Isoform 2 (identifier: Q8K2V6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-698: L → LPSSCLANEL

Show »
Length:984
Mass (Da):113,331
Checksum:iF5C9BCD9E209DF25
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WS00A0A087WS00_MOUSE
Importin-11
Ipo11
88Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349A → V in BAC40005 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010935698L → LPSSCLANEL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029746 mRNA Translation: AAH29746.1
BC031900 mRNA Translation: AAH31900.1
AK087793 mRNA Translation: BAC40005.1
CCDSiCCDS36776.1 [Q8K2V6-1]
RefSeqiNP_083941.2, NM_029665.3 [Q8K2V6-1]
XP_006517849.1, XM_006517786.3
UniGeneiMm.132208
Mm.482687

Genome annotation databases

EnsembliENSMUST00000080856; ENSMUSP00000079667; ENSMUSG00000042590 [Q8K2V6-1]
ENSMUST00000186033; ENSMUSP00000140046; ENSMUSG00000042590 [Q8K2V6-2]
GeneIDi76582
KEGGimmu:76582
UCSCiuc007rtx.1 mouse [Q8K2V6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029746 mRNA Translation: AAH29746.1
BC031900 mRNA Translation: AAH31900.1
AK087793 mRNA Translation: BAC40005.1
CCDSiCCDS36776.1 [Q8K2V6-1]
RefSeqiNP_083941.2, NM_029665.3 [Q8K2V6-1]
XP_006517849.1, XM_006517786.3
UniGeneiMm.132208
Mm.482687

3D structure databases

ProteinModelPortaliQ8K2V6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079667

PTM databases

iPTMnetiQ8K2V6
PhosphoSitePlusiQ8K2V6
SwissPalmiQ8K2V6

Proteomic databases

EPDiQ8K2V6
PaxDbiQ8K2V6
PeptideAtlasiQ8K2V6
PRIDEiQ8K2V6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080856; ENSMUSP00000079667; ENSMUSG00000042590 [Q8K2V6-1]
ENSMUST00000186033; ENSMUSP00000140046; ENSMUSG00000042590 [Q8K2V6-2]
GeneIDi76582
KEGGimmu:76582
UCSCiuc007rtx.1 mouse [Q8K2V6-1]

Organism-specific databases

CTDi51194
MGIiMGI:2442377 Ipo11

Phylogenomic databases

eggNOGiKOG1993 Eukaryota
COG5657 LUCA
GeneTreeiENSGT00390000014071
HOGENOMiHOG000008140
HOVERGENiHBG061387
InParanoidiQ8K2V6
OMAiYVFHEGT
OrthoDBiEOG091G01EL
PhylomeDBiQ8K2V6
TreeFamiTF324336

Miscellaneous databases

PROiPR:Q8K2V6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042590 Expressed in 278 organ(s), highest expression level in blood
CleanExiMM_IPO11
ExpressionAtlasiQ8K2V6 baseline and differential
GenevisibleiQ8K2V6 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPO11_MOUSE
AccessioniPrimary (citable) accession number: Q8K2V6
Secondary accession number(s): Q8BU45, Q8K0B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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