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Protein

COMM domain-containing protein 9

Gene

Commd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

GO - Biological processi

  • cholesterol homeostasis Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • sodium ion transport Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 9
Gene namesi
Name:Commd9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923751 Commd9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000774042 – 198COMM domain-containing protein 9Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8K2Q0
MaxQBiQ8K2Q0
PaxDbiQ8K2Q0
PeptideAtlasiQ8K2Q0
PRIDEiQ8K2Q0

PTM databases

iPTMnetiQ8K2Q0
PhosphoSitePlusiQ8K2Q0

Expressioni

Gene expression databases

BgeeiENSMUSG00000027163
CleanExiMM_COMMD9
GenevisibleiQ8K2Q0 MM

Interactioni

Subunit structurei

Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028584

Structurei

3D structure databases

ProteinModelPortaliQ8K2Q0
SMRiQ8K2Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini122 – 196COMMPROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410II5T Eukaryota
ENOG4111H94 LUCA
GeneTreeiENSGT00390000006218
HOGENOMiHOG000232004
HOVERGENiHBG080522
InParanoidiQ8K2Q0
KOiK22565
OMAiVSTWRTE
OrthoDBiEOG091G1AK9
PhylomeDBiQ8K2Q0
TreeFamiTF323880

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037360 COMMD9
PANTHERiPTHR15663 PTHR15663, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K2Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTAEHFV ALQSLLKASS KDVVRQLCQE SFSSSCLDSE SLLDKTCSSL
60 70 80 90 100
SVPQGEAAQL LQALHHFTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK
110 120 130 140 150
IIVEHISTWR AEAQANQISL PRLVDLDWRV DIKTSSDNIS RMAVPTCLLQ
160 170 180 190
MKIQEDPSLC GEKPSISAVT MELSKETLDT MLDGLGRIRD QLSAVANK
Length:198
Mass (Da):21,850
Last modified:August 16, 2005 - v3
Checksum:i24796550D76F6724
GO

Sequence cautioni

The sequence AAH30374 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21 – 24KDVV → PTRP in AAH56201 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007640 mRNA Translation: BAB25155.1
AK154731 mRNA Translation: BAE32794.1
BC030374 mRNA Translation: AAH30374.1 Different initiation.
BC043684 mRNA Translation: AAH43684.1
BC056201 mRNA Translation: AAH56201.1
BC060058 mRNA Translation: AAH60058.1
CCDSiCCDS16465.1
RefSeqiNP_083911.1, NM_029635.3
UniGeneiMm.330424

Genome annotation databases

EnsembliENSMUST00000028584; ENSMUSP00000028584; ENSMUSG00000027163
GeneIDi76501
KEGGimmu:76501
UCSCiuc008lhq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOMD9_MOUSE
AccessioniPrimary (citable) accession number: Q8K2Q0
Secondary accession number(s): Q3U3J2
, Q7TNP5, Q811K2, Q9D8V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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