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UniProtKB - Q8K2P7 (S38A1_MOUSE)

Entry version 133 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Sodium-coupled neutral amino acid transporter 1

Gene

Slc38a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by lithium, potassium, choline ions, N-methyl-D-glucamine and 2-methylamino-isobutyric acid (MeAIB).By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Decrease in pH from 8.0 to 7.0 results in decreased affinity for L-glutamine.
  1. KM=2400 µM for L-glutamine (at pH 7.0)1 Publication
  2. KM=890 µM for L-glutamine (at pH 7.5)1 Publication
  3. KM=540 µM for L-glutamine (at pH 8.0)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-MMU-210455, Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-MMU-352230, Amino acid transport across the plasma membrane

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 1
    Alternative name(s):
    Amino acid transporter A1
    MNat2
    N-system amino acid transporter 2
    Solute carrier family 38 member 1
    System A amino acid transporter 1
    System N amino acid transporter 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Slc38a1
    Synonyms:Nat2, Snat1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...    MGIi    		MGI:2145895, Slc38a1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
    Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
    Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
    Topological domaini134 – 148CytoplasmicSequence analysisAdd BLAST15
    Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
    Topological domaini170 – 188ExtracellularSequence analysisAdd BLAST19
    Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
    Topological domaini212 – 216CytoplasmicSequence analysis5
    Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
    Topological domaini238 – 273ExtracellularSequence analysisAdd BLAST36
    Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
    Topological domaini295 – 310CytoplasmicSequence analysisAdd BLAST16
    Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
    Topological domaini332 – 348ExtracellularSequence analysisAdd BLAST17
    Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
    Topological domaini370 – 391CytoplasmicSequence analysisAdd BLAST22
    Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
    Topological domaini413 – 414ExtracellularSequence analysis2
    Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
    Topological domaini436 – 450CytoplasmicSequence analysisAdd BLAST15
    Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
    Topological domaini472 – 485ExtracellularSequence analysisAdd BLAST14

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003104761 – 485Sodium-coupled neutral amino acid transporter 1Add BLAST485

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineCombined sources1
    Modified residuei11PhosphothreonineCombined sources1
    Modified residuei25PhosphoserineBy similarity1
    Modified residuei28PhosphoserineBy similarity1
    Modified residuei49PhosphoserineBy similarity1
    Modified residuei52PhosphoserineBy similarity1
    Modified residuei54PhosphothreonineBy similarity1
    Modified residuei56PhosphoserineBy similarity1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi245 ↔ 262PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q8K2P7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q8K2P7

    PeptideAtlas

    More...    PeptideAtlasi    		Q8K2P7

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q8K2P7

    PTM databases

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q8K2P7, 2 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q8K2P7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q8K2P7

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		Q8K2P7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Specifically expressed in brain and retina (at protein level). Also detected in spleen, small intestine and lung.1 Publication

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by BDNF.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSMUSG00000023169, Expressed in pituitary gland and 293 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q8K2P7, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		222905, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		10090.ENSMUSP00000097833

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q8K2P7, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the amino acid/polyamine transporter 2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1305, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000160716

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_009020_0_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q8K2P7

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		LVIYDWV

    Database of Orthologous Groups

    More...    OrthoDBi    		697331at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q8K2P7

    TreeFam database of animal gene trees

    More...    TreeFami    		TF328787

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR013057, AA_transpt_TM

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF01490, Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q8K2P7-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MMHFKSGLEL TELQNMTVPE DDNVSNDSND FTEVENGQIN SKFISDRESR 
            60         70         80         90        100
    RSLTNSHLEK RKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG 
           110        120        130        140        150
    ILLFLILLTS VTLLSIYSIN LLLICSKETG CMVYEKLGEQ VFGTTGKLVI 
           160        170        180        190        200
    FGATSLQNTG AMLSYLFIVK NELPSAIKSL MGEEDAFSAW YVDGRVLVVM 
           210        220        230        240        250
    VTFGIILPLC LLKNLGYLGY TSGFSLSCMM FFLIVVIYKK FQTPCMSVEQ 
           260        270        280        290        300
    NSTVSANVTD ACTPKYVTFN SKTVYALPTI AFAFVCHPSV LPIYSELKDR 
           310        320        330        340        350
    SQKKMQMVSN ISFFAMFVMY FLTAIFGYLT FYEKVQSDLL HKYQSTGDIL 
           360        370        380        390        400
    ILTVRLAVIV AVILTVPVLF FTVRSSLFEL AKKTKFHLCR HVLVTIILLI 
           410        420        430        440        450
    IINLLVIFIP SMKDIFGVVG VTSANMLIFI LPSSLYLKIT NQDGDKGTQR 
           460        470        480 
    IWAALFLGLG VLFSLISIPL VIYDWACSSG TDEGH
    Length:485
    Mass (Da):53,795
    Last modified:October 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1171E1458818977C
    GO
    Isoform 2 (identifier: Q8K2P7-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         333-344: EKVQSDLLHKYQ → GKLLPLAMPICT
         345-485: Missing.

    Show »
    Length:344
    Mass (Da):38,112
    Checksum:i1AFA524A4E9C22AE
    GO
    Isoform 3 (identifier: Q8K2P7-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-72: IPGTTS → VSIICM
         73-485: Missing.

    Show »
    Length:72
    Mass (Da):8,358
    Checksum:i01A6F7B92D9D8741
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48E → G in BAE38067 (PubMed:16141072).Curated1
    Sequence conflicti244P → H in BAC33064 (PubMed:16141072).Curated1
    Sequence conflicti354V → A in AAG43433 (PubMed:11325958).Curated1
    Sequence conflicti360V → A in AAG43433 (PubMed:11325958).Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02930567 – 72IPGTTS → VSIICM in isoform 3. 1 Publication6
    Alternative sequenceiVSP_02930673 – 485Missing in isoform 3. 1 PublicationAdd BLAST413
    Alternative sequenceiVSP_029307333 – 344EKVQS…LHKYQ → GKLLPLAMPICT in isoform 2. 1 PublicationAdd BLAST12
    Alternative sequenceiVSP_029308345 – 485Missing in isoform 2. 1 PublicationAdd BLAST141

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF184240 mRNA Translation: AAG43433.2
    AK029189 mRNA Translation: BAC26341.1
    AK034130 mRNA Translation: BAC28597.1
    AK035098 mRNA Translation: BAC28944.1
    AK047459 mRNA Translation: BAC33064.1
    AK049294 mRNA Translation: BAC33663.1
    AK050914 mRNA Translation: BAC34457.1
    AK081724 mRNA Translation: BAC38310.1
    AK162612 mRNA Translation: BAE36989.1
    AK163914 mRNA Translation: BAE37532.1
    AK165188 mRNA Translation: BAE38067.1
    BC030378 mRNA Translation: AAH30378.1
    BC066815 mRNA Translation: AAH66815.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS27777.1 [Q8K2P7-1]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001159928.1, NM_001166456.1 [Q8K2P7-1]
    NP_001159930.1, NM_001166458.1 [Q8K2P7-1]
    NP_598847.2, NM_134086.4 [Q8K2P7-1]
    XP_006520298.1, XM_006520235.3 [Q8K2P7-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENSMUST00000088452; ENSMUSP00000085799; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000088454; ENSMUSP00000085801; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000100262; ENSMUSP00000097833; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000230767; ENSMUSP00000155160; ENSMUSG00000023169 [Q8K2P7-3]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		105727

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		mmu:105727

    UCSC genome browser

    More...    UCSCi    		uc007xkh.2, mouse [Q8K2P7-1]
    uc007xkk.2, mouse [Q8K2P7-2]
    uc007xkl.2, mouse [Q8K2P7-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF184240 mRNA Translation: AAG43433.2
    AK029189 mRNA Translation: BAC26341.1
    AK034130 mRNA Translation: BAC28597.1
    AK035098 mRNA Translation: BAC28944.1
    AK047459 mRNA Translation: BAC33064.1
    AK049294 mRNA Translation: BAC33663.1
    AK050914 mRNA Translation: BAC34457.1
    AK081724 mRNA Translation: BAC38310.1
    AK162612 mRNA Translation: BAE36989.1
    AK163914 mRNA Translation: BAE37532.1
    AK165188 mRNA Translation: BAE38067.1
    BC030378 mRNA Translation: AAH30378.1
    BC066815 mRNA Translation: AAH66815.1
    CCDSiCCDS27777.1 [Q8K2P7-1]
    RefSeqiNP_001159928.1, NM_001166456.1 [Q8K2P7-1]
    NP_001159930.1, NM_001166458.1 [Q8K2P7-1]
    NP_598847.2, NM_134086.4 [Q8K2P7-1]
    XP_006520298.1, XM_006520235.3 [Q8K2P7-1]

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi222905, 1 interactor
    STRINGi10090.ENSMUSP00000097833

    PTM databases

    GlyGeniQ8K2P7, 2 sites
    iPTMnetiQ8K2P7
    PhosphoSitePlusiQ8K2P7
    SwissPalmiQ8K2P7

    Proteomic databases

    EPDiQ8K2P7
    PaxDbiQ8K2P7
    PeptideAtlasiQ8K2P7
    PRIDEiQ8K2P7

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...    ABCDi    		Q8K2P7, 2 sequenced antibodies

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		7400, 192 antibodies

    Genome annotation databases

    EnsembliENSMUST00000088452; ENSMUSP00000085799; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000088454; ENSMUSP00000085801; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000100262; ENSMUSP00000097833; ENSMUSG00000023169 [Q8K2P7-1]
    ENSMUST00000230767; ENSMUSP00000155160; ENSMUSG00000023169 [Q8K2P7-3]
    GeneIDi105727
    KEGGimmu:105727
    UCSCiuc007xkh.2, mouse [Q8K2P7-1]
    uc007xkk.2, mouse [Q8K2P7-2]
    uc007xkl.2, mouse [Q8K2P7-3]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		81539
    MGIiMGI:2145895, Slc38a1

    Phylogenomic databases

    eggNOGiKOG1305, Eukaryota
    GeneTreeiENSGT00940000160716
    HOGENOMiCLU_009020_0_2_1
    InParanoidiQ8K2P7
    OMAiLVIYDWV
    OrthoDBi697331at2759
    PhylomeDBiQ8K2P7
    TreeFamiTF328787

    Enzyme and pathway databases

    ReactomeiR-MMU-210455, Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-MMU-352230, Amino acid transport across the plasma membrane

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		105727, 1 hit in 20 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		Slc38a1, mouse

    Protein Ontology

    More...    PROi    		PR:Q8K2P7
    RNActiQ8K2P7, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSMUSG00000023169, Expressed in pituitary gland and 293 other tissues
    GenevisibleiQ8K2P7, MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057, AA_transpt_TM
    PfamiView protein in Pfam
    PF01490, Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS38A1_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K2P7
    Secondary accession number(s): Q3TNM1
    , Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q99PR1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 1, 2002
    Last modified: December 2, 2020
    This is version 133 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
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