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Protein

BTB/POZ domain-containing protein 6

Gene

Btbd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity).By similarity

GO - Biological processi

  • neurogenesis Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 6
Gene namesi
Name:Btbd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:3026623 Btbd6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862141 – 488BTB/POZ domain-containing protein 6Add BLAST488

Proteomic databases

PaxDbiQ8K2J9
PRIDEiQ8K2J9

PTM databases

PhosphoSitePlusiQ8K2J9

Expressioni

Gene expression databases

BgeeiENSMUSG00000002803 Expressed in 231 organ(s), highest expression level in heart left ventricle
CleanExiMM_BTBD6
ExpressionAtlasiQ8K2J9 baseline and differential
GenevisibleiQ8K2J9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002880

Structurei

3D structure databases

ProteinModelPortaliQ8K2J9
SMRiQ8K2J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 156BTBPROSITE-ProRule annotationAdd BLAST71

Phylogenomic databases

eggNOGiKOG2075 Eukaryota
ENOG410XQ3X LUCA
GeneTreeiENSGT00550000074511
HOGENOMiHOG000293364
HOVERGENiHBG050743
InParanoidiQ8K2J9
KOiK10478
OMAiKSEGFCE
PhylomeDBiQ8K2J9

Family and domain databases

Gene3Di2.60.120.820, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR012983 PHR
IPR038648 PHR_sf
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF08005 PHR, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8K2J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAELYPPAS PSAATATDIA NSNAAGAAES TKVGLCCPPC LAPAPLPPLP
60 70 80 90 100
APPLPDNNNP ESPNWQSFHP TLRERNALMF NNELMADVHF IVGALGAARR
110 120 130 140 150
VPAHKYVLAV GSSVFYAMFY GDLAEVKSEI HIPDVEPAAF LVLLKYMYSD
160 170 180 190 200
EIDLEADTVL ATLYAAKKYI VPALAKACVN FLETSLEAKN ACVLLSQSRL
210 220 230 240 250
FEEPELTQRC WEVIDAQAEM ALRSEGFCEI DRQTLEIIVT REALNTKEAV
260 270 280 290 300
VFEAVLNWAE AECKRQGLPV TPHNKRHVLG RALYLVRIPT MTLEEFANGA
310 320 330 340 350
AQSDILTLEE THNIFLWYTA AKKPLLDFPL TKRKGLAPQR CHRFQSSAYR
360 370 380 390 400
SNQWRYRGRC DSIQFAVDRR VFIAGLGLYG SSSGKAEYSV KIELKRLGMV
410 420 430 440 450
LAQNLTKFVS DGSSNTFPVW FEHPVQVEQD TFYTASAVLD GSELSYFGQE
460 470 480
GMTEVQCGKV AFQFQCSSDS TNGTGVQGGQ IPELIFYA
Length:488
Mass (Da):53,842
Last modified:July 28, 2009 - v2
Checksum:i8C4A24F6B5BDCD14
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E817G5E817_MOUSE
BTB (POZ) domain containing 6, isof...
Btbd6 mCG_127240
539Annotation score:
A0A1Y7VM12A0A1Y7VM12_MOUSE
BTB/POZ domain-containing protein 6
Btbd6
123Annotation score:
A0A1Y7VLS5A0A1Y7VLS5_MOUSE
BTB/POZ domain-containing protein 6
Btbd6
241Annotation score:
A0A1Y7VN14A0A1Y7VN14_MOUSE
BTB/POZ domain-containing protein 6
Btbd6
88Annotation score:
A0A1Y7VJT6A0A1Y7VJT6_MOUSE
BTB/POZ domain-containing protein 6
Btbd6
95Annotation score:

Sequence cautioni

The sequence AAH31195 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146991 mRNA Translation: BAE27593.1
CH466549 Genomic DNA Translation: EDL18570.1
BC031195 mRNA Translation: AAH31195.1 Different initiation.
CCDSiCCDS49194.1
RefSeqiNP_001139372.1, NM_001145900.1
NP_964008.2, NM_201646.2
XP_006516119.1, XM_006516056.3
UniGeneiMm.440140

Genome annotation databases

EnsembliENSMUST00000165079; ENSMUSP00000127286; ENSMUSG00000002803
ENSMUST00000221104; ENSMUSP00000152889; ENSMUSG00000002803
GeneIDi399566
KEGGimmu:399566
UCSCiuc011yvh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146991 mRNA Translation: BAE27593.1
CH466549 Genomic DNA Translation: EDL18570.1
BC031195 mRNA Translation: AAH31195.1 Different initiation.
CCDSiCCDS49194.1
RefSeqiNP_001139372.1, NM_001145900.1
NP_964008.2, NM_201646.2
XP_006516119.1, XM_006516056.3
UniGeneiMm.440140

3D structure databases

ProteinModelPortaliQ8K2J9
SMRiQ8K2J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000002880

PTM databases

PhosphoSitePlusiQ8K2J9

Proteomic databases

PaxDbiQ8K2J9
PRIDEiQ8K2J9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165079; ENSMUSP00000127286; ENSMUSG00000002803
ENSMUST00000221104; ENSMUSP00000152889; ENSMUSG00000002803
GeneIDi399566
KEGGimmu:399566
UCSCiuc011yvh.1 mouse

Organism-specific databases

CTDi90135
MGIiMGI:3026623 Btbd6

Phylogenomic databases

eggNOGiKOG2075 Eukaryota
ENOG410XQ3X LUCA
GeneTreeiENSGT00550000074511
HOGENOMiHOG000293364
HOVERGENiHBG050743
InParanoidiQ8K2J9
KOiK10478
OMAiKSEGFCE
PhylomeDBiQ8K2J9

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8K2J9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002803 Expressed in 231 organ(s), highest expression level in heart left ventricle
CleanExiMM_BTBD6
ExpressionAtlasiQ8K2J9 baseline and differential
GenevisibleiQ8K2J9 MM

Family and domain databases

Gene3Di2.60.120.820, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR012983 PHR
IPR038648 PHR_sf
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF08005 PHR, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTBD6_MOUSE
AccessioniPrimary (citable) accession number: Q8K2J9
Secondary accession number(s): Q3UIB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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