Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 150 (12 Aug 2020)
Sequence version 2 (02 Oct 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Gene

Plcd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly activated by phosphatidic acid. Inhibited by phosphatidylethanolamine (PtdEtn), phosphatidylcholine (PtdCho), sphingomyelin and phosphatidylserine (PtdSer) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei348PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi349Calcium 1; catalyticBy similarity1
Metal bindingi378Calcium 1; catalyticBy similarity1
Metal bindingi380Calcium 1; catalyticBy similarity1
Active sitei393PROSITE-ProRule annotation1
Metal bindingi427Calcium 1; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei476SubstrateBy similarity1
Binding sitei478SubstrateBy similarity1
Binding sitei553SubstrateBy similarity1
Binding sitei580SubstrateBy similarity1
Metal bindingi679Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi681Calcium 2By similarity1
Metal bindingi705Calcium 2By similarity1
Metal bindingi734Calcium 3By similarity1
Metal bindingi735Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi736Calcium 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi191 – 2021Sequence analysisAdd BLAST12
Calcium bindingi227 – 2382Sequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001068

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-delta-3
Phospholipase C-delta-3
Short name:
PLC-delta-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plcd3
Synonyms:Kiaa1964
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107451, Plcd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking Plcd1 and Plcd3 die between 11.5 and 13.5 dpc. They exhibit severe disruption of the normal labyrinth architecture in the placenta and decreased placental vascularization, as well as abnormal proliferation and apoptosis of trophoblasts in the labyrinth area. Furthermore, Plcd1 and Plcd3 double knockout embryos supplied with a normal placenta by the tetraploid aggregation method survive beyond 14.5 dpc, indicating that the embryonic lethality is caused by a defect in trophoblasts.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068221 – 7851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3Add BLAST785

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei101PhosphoserineBy similarity1
Modified residuei492PhosphoserineCombined sources1
Modified residuei569PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K2J0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K2J0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K2J0

PeptideAtlas

More...
PeptideAtlasi
Q8K2J0

PRoteomics IDEntifications database

More...
PRIDEi
Q8K2J0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K2J0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K2J0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020937, Expressed in retina and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K2J0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K2J0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
215387, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099366

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K2J0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K2J0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 168PHAdd BLAST104
Domaini178 – 213EF-hand 1Add BLAST36
Domaini214 – 249EF-hand 2Add BLAST36
Domaini246 – 281EF-hand 3Add BLAST36
Domaini333 – 478PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST146
Domaini524 – 640PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini636 – 765C2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 97Substrate bindingBy similarityAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domain is a Ca2+-dependent membrane-targeting module.By similarity
The PH domain mediates interaction with the surface membrane by binding to PIP2.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156993

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002738_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K2J0

KEGG Orthology (KO)

More...
KOi
K05857

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTWIHSY

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K2J0

TreeFam database of animal gene trees

More...
TreeFami
TF313216

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16218, EFh_PI-PLCdelta3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR028406, PLC-delta3
IPR039504, PLC-delta3_EF-hand
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336, PTHR10336, 1 hit
PTHR10336:SF33, PTHR10336:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF14788, EF-hand_10, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K2J0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCGGWKRSR RSPEESRVSA QVAAPLAFPP SPASSDSSTK RPGLRALKKM
60 70 80 90 100
GLTEDEDVQA MLRGSRLLKI RSRTWHKERL YRLQEDGLSV WFQRRIPRAA
110 120 130 140 150
SKHIFFVQHI EAVREGHQSE GLRRFGGAFA PACCLTIAFK GRRKNLDLAA
160 170 180 190 200
PTAEEAQRWV RGLAKLRARL DAMSQRERLD HWIHSYLHRA DSDQDSKMSF
210 220 230 240 250
KEIKSLLRMV NVDMNDMYAY RLFKECDHSN NERLEGAEIE AFLRRLLKRP
260 270 280 290 300
ELEEIFRRYS GEDRVLSASE LLEFLEDQGE DGATLACAQQ LIQTYELNET
310 320 330 340 350
AKQHELMTLD GFMMYLLSPE GAALNVAHTC VFQDMGQPLA HYFISSSHNT
360 370 380 390 400
YLTDSQIGGT SSTEAYIRAF AQGCRCVELD CWEGPGGEPV IYHGHTLTSK
410 420 430 440 450
ILFRDVIQAV RDHAFTSSPY PVILSLENHC GLEQQAVMAR HLRSILGDML
460 470 480 490 500
VTQALDSQNP EELPSPEQLK GRILVKGKKL PAARSEDGRI LSDREEEEEE
510 520 530 540 550
EEEAEEALEA AEQRSRAKQI SPELSALAVY CCATRLRTLD PSPGPPQSCT
560 570 580 590 600
VGSLSERKAR KFTREAGTSF VRHNTQQLTR VYPLGLRMNS ANYNPQEMWN
610 620 630 640 650
SGCQLVALNF QTPGYEMDLN TGRFLINGQC GYVLKPAYLR QLNTTFDPEC
660 670 680 690 700
PGPPRTTLAI QVLTAQQLPK LNAEKPSSIV DPLVRVEIHG VPEDCAQKET
710 720 730 740 750
DYVLNNGFNP CWEQTLQFRL RAPELVLVRF VVEDYDTTSP NDFVGQSTLP
760 770 780
LSSLKQGYRH IHLLSKDGAS LAPATLFVHI RIQNS
Length:785
Mass (Da):88,607
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B3DE84FB7A52238
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AAE0F7AAE0_MOUSE
Phosphoinositide phospholipase C
Plcd3
471Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC32829 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32589 differs from that shown. Intron retention.Curated
The sequence CAM22088 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti199S → N in BAE26150 (PubMed:16141072).Curated1
Sequence conflicti301 – 302AK → GE in BAD32589 (PubMed:15368895).Curated2
Sequence conflicti378E → K in BAE26150 (PubMed:16141072).Curated1
Sequence conflicti540D → E in AAH31392 (PubMed:15489334).Curated1
Sequence conflicti659A → T in BAE26150 (PubMed:16141072).Curated1
Sequence conflicti660I → V in BAE26150 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173311 Transcribed RNA Translation: BAD32589.1 Sequence problems.
AK046669 mRNA Translation: BAC32829.1 Different initiation.
AK144950 mRNA Translation: BAE26150.1
AL731805 Genomic DNA Translation: CAM22088.1 Sequence problems.
AL731805 Genomic DNA Translation: CAM22089.1
BC031392 mRNA Translation: AAH31392.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25512.1

NCBI Reference Sequences

More...
RefSeqi
NP_690026.2, NM_152813.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000103077; ENSMUSP00000099366; ENSMUSG00000020937

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72469

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72469

UCSC genome browser

More...
UCSCi
uc007ltf.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173311 Transcribed RNA Translation: BAD32589.1 Sequence problems.
AK046669 mRNA Translation: BAC32829.1 Different initiation.
AK144950 mRNA Translation: BAE26150.1
AL731805 Genomic DNA Translation: CAM22088.1 Sequence problems.
AL731805 Genomic DNA Translation: CAM22089.1
BC031392 mRNA Translation: AAH31392.1
CCDSiCCDS25512.1
RefSeqiNP_690026.2, NM_152813.3

3D structure databases

SMRiQ8K2J0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215387, 3 interactors
STRINGi10090.ENSMUSP00000099366

Chemistry databases

SwissLipidsiSLP:000001068

PTM databases

iPTMnetiQ8K2J0
PhosphoSitePlusiQ8K2J0

Proteomic databases

jPOSTiQ8K2J0
MaxQBiQ8K2J0
PaxDbiQ8K2J0
PeptideAtlasiQ8K2J0
PRIDEiQ8K2J0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8300, 91 antibodies

Genome annotation databases

EnsembliENSMUST00000103077; ENSMUSP00000099366; ENSMUSG00000020937
GeneIDi72469
KEGGimmu:72469
UCSCiuc007ltf.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113026
MGIiMGI:107451, Plcd3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0169, Eukaryota
GeneTreeiENSGT00940000156993
HOGENOMiCLU_002738_0_2_1
InParanoidiQ8K2J0
KOiK05857
OMAiHTWIHSY
OrthoDBi368239at2759
PhylomeDBiQ8K2J0
TreeFamiTF313216

Enzyme and pathway databases

ReactomeiR-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
72469, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plcd3, mouse

Protein Ontology

More...
PROi
PR:Q8K2J0
RNActiQ8K2J0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020937, Expressed in retina and 254 other tissues
ExpressionAtlasiQ8K2J0, baseline and differential
GenevisibleiQ8K2J0, MM

Family and domain databases

CDDicd16218, EFh_PI-PLCdelta3, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR028406, PLC-delta3
IPR039504, PLC-delta3_EF-hand
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336, PTHR10336, 1 hit
PTHR10336:SF33, PTHR10336:SF33, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF14788, EF-hand_10, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCD3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K2J0
Secondary accession number(s): A2AHR0
, A2AHR1, Q3UME8, Q69Z55, Q8BL19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: August 12, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again