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Entry version 112 (02 Jun 2021)
Sequence version 3 (03 Oct 2012)
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Protein

Coiled-coil alpha-helical rod protein 1

Gene

Cchcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a regulator of keratinocyte proliferation or differentiation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil alpha-helical rod protein 1
Alternative name(s):
Alpha-helical coiled-coil rod protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cchcr1
Synonyms:Hcr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385321, Cchcr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894171 – 770Coiled-coil alpha-helical rod protein 1Add BLAST770

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K2I2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K2I2

PRoteomics IDEntifications database

More...
PRIDEi
Q8K2I2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
265610

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K2I2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K2I2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040312, Expressed in cardiac ventricle and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8K2I2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K2I2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
232162, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000046612

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K2I2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K2I2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 592DisorderedSequence analysisAdd BLAST20
Regioni641 – 672DisorderedSequence analysisAdd BLAST32
Regioni700 – 721DisorderedSequence analysisAdd BLAST22
Regioni744 – 770DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili56 – 289Sequence analysisAdd BLAST234
Coiled coili334 – 420Sequence analysisAdd BLAST87
Coiled coili476 – 669Sequence analysisAdd BLAST194

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi646 – 672Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi703 – 719Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3802, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153251

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009996_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K2I2

Identification of Orthologs from Complete Genome Data

More...
OMAi
QELEQSW

Database of Orthologous Groups

More...
OrthoDBi
1046571at2759

TreeFam database of animal gene trees

More...
TreeFami
TF336947

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009800, HCR

The PANTHER Classification System

More...
PANTHERi
PTHR46822, PTHR46822, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07111, HCR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K2I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPSGFAGL VPPSHFQARP LPTLPRMAPT WASDVPLVQS PASQDVLERR
60 70 80 90 100
LDAQRSTVTT WGQDFCGDGQ GLGRRGRSLE LGFSSALSQQ AELISRQLQE
110 120 130 140 150
LRRLEEEVRS LRETSLQQKM RLETQAVELD ALAVAEKAGQ AEAEGLRTAL
160 170 180 190 200
AGAEMVRKNL EEAKHKELEE IQSLHQEQLS SLTQAHQKAL DSLASKAEGL
210 220 230 240 250
EKSLNSLETK RAGEAKQLAM AQKEADMLRN QLSKTQEELE AQVTLVESLR
260 270 280 290 300
KYVGEQVLPE FPSQEWELER KELLDTLKHL KEDRADLQAT VELLQVRVQS
310 320 330 340 350
LTHMLALQEE ELTRKIQPLD PLEPEFPKKC RSLLRNWREK VFALMVQLKA
360 370 380 390 400
QDLQHRDSTS QLRIQVAELQ EQVTSQSQEQ AILQRALQDK TAQVEVERMS
410 420 430 440 450
TKSLQMELDQ AQEARRRQEQ QIASAEEQLK FVVGAMNSTQ AKLQSTMTRM
460 470 480 490 500
DQAVARIPSL SNRLSYAVRK VHTIKGLMAR KVALAQLRVE SSPPSEAAPP
510 520 530 540 550
LDTDLSVELE QLREERNRLD AELQLSAHLI QQEVGRAREQ GEVERRRLIE
560 570 580 590 600
VAQQLEQELQ RAQESLASVG QQLEAARRGQ QESTEEAASL RQELTQQQEI
610 620 630 640 650
YGQALQEKVA EVETRLREQL SDTKRRLNEA RREQAKAVVS LRQIQHKATQ
660 670 680 690 700
EKERNQELRR LQDEARKEEG QRLTRRVQEL ERDKNLMLQR LLAVLPSGVN
710 720 730 740 750
KKCSPRSVES SSSESPAAAS CKESVKGSLT VLLDNLQGLS EAISRDEDIC
760 770
VEDNQNTKKT KNPPSDPLLS
Length:770
Mass (Da):87,105
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAC0D3143E0660C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWS7G3UWS7_MOUSE
Alpha-helical coiled-coil rod prote...
Cchcr1
867Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH31416 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti720S → L in AAH31416 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR974473 Genomic DNA No translation available.
CH466559 Genomic DNA Translation: EDL23219.1
BC031416 mRNA Translation: AAH31416.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50090.1

NCBI Reference Sequences

More...
RefSeqi
NP_666360.2, NM_146248.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312
ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
240084

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:240084

UCSC genome browser

More...
UCSCi
uc008chy.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974473 Genomic DNA No translation available.
CH466559 Genomic DNA Translation: EDL23219.1
BC031416 mRNA Translation: AAH31416.1 Different initiation.
CCDSiCCDS50090.1
RefSeqiNP_666360.2, NM_146248.2

3D structure databases

SMRiQ8K2I2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi232162, 1 interactor
STRINGi10090.ENSMUSP00000046612

PTM databases

iPTMnetiQ8K2I2
PhosphoSitePlusiQ8K2I2

Proteomic databases

MaxQBiQ8K2I2
PaxDbiQ8K2I2
PRIDEiQ8K2I2
ProteomicsDBi265610

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53233, 90 antibodies

Genome annotation databases

EnsembliENSMUST00000045956; ENSMUSP00000046612; ENSMUSG00000040312
ENSMUST00000164242; ENSMUSP00000132028; ENSMUSG00000040312
GeneIDi240084
KEGGimmu:240084
UCSCiuc008chy.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54535
MGIiMGI:2385321, Cchcr1

Phylogenomic databases

eggNOGiKOG3802, Eukaryota
GeneTreeiENSGT00940000153251
HOGENOMiCLU_009996_0_0_1
InParanoidiQ8K2I2
OMAiQELEQSW
OrthoDBi1046571at2759
TreeFamiTF336947

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
240084, 4 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cchcr1, mouse

Protein Ontology

More...
PROi
PR:Q8K2I2
RNActiQ8K2I2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040312, Expressed in cardiac ventricle and 168 other tissues
ExpressionAtlasiQ8K2I2, baseline and differential
GenevisibleiQ8K2I2, MM

Family and domain databases

InterProiView protein in InterPro
IPR009800, HCR
PANTHERiPTHR46822, PTHR46822, 1 hit
PfamiView protein in Pfam
PF07111, HCR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCHCR_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K2I2
Secondary accession number(s): G3UWG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 3, 2012
Last modified: June 2, 2021
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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