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UniProtKB - Q8K2I1 (FNTB_MOUSE)
Protein
Protein farnesyltransferase subunit beta
Gene
Fntb
Organism
Mus musculus (Mouse)
Status
Functioni
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
1 PublicationCatalytic activityi
- (2E,6E)-farnesyl diphosphate + L-cysteinyl-[protein] = diphosphate + S-(2E,6E)-farnesyl-L-cysteinyl-[protein]1 PublicationEC:2.5.1.581 Publication
Cofactori
Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 102 | Important for selectivity against geranylgeranyl diphosphateBy similarity | 1 | |
Metal bindingi | 297 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 299 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 362 | Zinc; via tele nitrogen; catalyticBy similarity | 1 |
GO - Molecular functioni
- farnesyltranstransferase activity Source: MGI
- protein farnesyltransferase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
- negative regulation of cell population proliferation Source: MGI
- positive regulation of cell cycle Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of nitric-oxide synthase biosynthetic process Source: MGI
- protein farnesylation Source: UniProtKB
- protein prenylation Source: GO_Central
- regulation of fibroblast proliferation Source: MGI
- response to cytokine Source: MGI
- response to inorganic substance Source: MGI
- response to organic cyclic compound Source: MGI
- wound healing Source: MGI
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Biological process | Lipid metabolism |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-9648002, RAS processing |
Names & Taxonomyi
Protein namesi | Recommended name: Protein farnesyltransferase subunit beta (EC:2.5.1.58)Short name: FTase-beta Alternative name(s): CAAX farnesyltransferase subunit beta Ras proteins prenyltransferase subunit beta |
Gene namesi | Name:Fntb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1861305, Fntb |
VEuPathDBi | HostDB:ENSMUSG00000033373 |
Subcellular locationi
Cytoskeleton
- microtubule associated complex Source: MGI
Other locations
- protein farnesyltransferase complex Source: UniProtKB
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119762 | 1 – 437 | Protein farnesyltransferase subunit betaAdd BLAST | 437 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8K2I1 |
MaxQBi | Q8K2I1 |
PaxDbi | Q8K2I1 |
PeptideAtlasi | Q8K2I1 |
PRIDEi | Q8K2I1 |
ProteomicsDBi | 267612 |
PTM databases
iPTMneti | Q8K2I1 |
PhosphoSitePlusi | Q8K2I1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000033373, Expressed in brain and 260 other tissues |
ExpressionAtlasi | Q8K2I1, baseline and differential |
Genevisiblei | Q8K2I1, MM |
Interactioni
Subunit structurei
Heterodimer of FNTA and FNTB.
1 PublicationProtein-protein interaction databases
BioGRIDi | 225746, 8 interactors |
ComplexPortali | CPX-2185, Protein farnesyltransferase complex |
STRINGi | 10090.ENSMUSP00000035498 |
Chemistry databases
BindingDBi | Q8K2I1 |
Miscellaneous databases
RNActi | Q8K2I1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 123 – 164 | PFTB 1Add BLAST | 42 | |
Repeati | 174 – 215 | PFTB 2Add BLAST | 42 | |
Repeati | 222 – 263 | PFTB 3Add BLAST | 42 | |
Repeati | 270 – 312 | PFTB 4Add BLAST | 43 | |
Repeati | 332 – 374 | PFTB 5Add BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 248 – 251 | Farnesyl diphosphate bindingBy similarity | 4 | |
Regioni | 291 – 294 | Farnesyl diphosphate bindingBy similarity | 4 | |
Regioni | 300 – 303 | Farnesyl diphosphate bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the protein prenyltransferase subunit beta family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0365, Eukaryota |
GeneTreei | ENSGT00950000183128 |
HOGENOMi | CLU_028946_0_1_1 |
InParanoidi | Q8K2I1 |
OMAi | THPLFNI |
OrthoDBi | 1042804at2759 |
PhylomeDBi | Q8K2I1 |
TreeFami | TF353162 |
Family and domain databases
CDDi | cd02893, FTase, 1 hit |
InterProi | View protein in InterPro IPR026872, FTB IPR001330, PFTB_repeat IPR045089, PGGT1B-like IPR008930, Terpenoid_cyclase/PrenylTrfase |
PANTHERi | PTHR11774, PTHR11774, 1 hit PTHR11774:SF6, PTHR11774:SF6, 1 hit |
Pfami | View protein in Pfam PF00432, Prenyltrans, 5 hits |
SUPFAMi | SSF48239, SSF48239, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q8K2I1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSSSFTYY CPPSSSPVWS EPLYSLRPEH VRERLQDDSV ETVTSIEQAK
60 70 80 90 100
VEEKIQEVFS SYKFNHLVPR LILQREKHFH YLKRGLRQLT DAYECLDASR
110 120 130 140 150
PWLCYWILHS LELLDEPIPQ IVATDVCQFL ELCQSPDGGF GGGPGQYPHL
160 170 180 190 200
APTYAAVNAL CIIGTEEAYN VINREKLLQY LYSLKQPDGS FLMHVGGEVD
210 220 230 240 250
VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG GVPGMEAHGG
260 270 280 290 300
YTFCGLAALV ILKKERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY
310 320 330 340 350
SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL
360 370 380 390 400
LDKPGKSRDF YHTCYCLSGL SIAQHFGSGA MLHDMVMGVP ENVLQPTHPV
410 420 430
YNIGPEKVIQ ATTHFLQKPV PGFEECEDEV TSDPATD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YWJ4 | D3YWJ4_MOUSE | Protein farnesyltransferase subunit... | Fntb | 471 | Annotation score: | ||
D6RGU2 | D6RGU2_MOUSE | Protein Churchill | Fntb | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC031417 mRNA Translation: AAH31417.1 |
CCDSi | CCDS25998.1 |
RefSeqi | NP_666039.1, NM_145927.2 |
Genome annotation databases
Ensembli | ENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373 |
GeneIDi | 110606 |
KEGGi | mmu:110606 |
UCSCi | uc007nyu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC031417 mRNA Translation: AAH31417.1 |
CCDSi | CCDS25998.1 |
RefSeqi | NP_666039.1, NM_145927.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PZ4 | X-ray | 2.10 | B | 2-427 | [»] | |
SMRi | Q8K2I1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 225746, 8 interactors |
ComplexPortali | CPX-2185, Protein farnesyltransferase complex |
STRINGi | 10090.ENSMUSP00000035498 |
Chemistry databases
BindingDBi | Q8K2I1 |
ChEMBLi | CHEMBL2096912 |
PTM databases
iPTMneti | Q8K2I1 |
PhosphoSitePlusi | Q8K2I1 |
Proteomic databases
EPDi | Q8K2I1 |
MaxQBi | Q8K2I1 |
PaxDbi | Q8K2I1 |
PeptideAtlasi | Q8K2I1 |
PRIDEi | Q8K2I1 |
ProteomicsDBi | 267612 |
Protocols and materials databases
DNASUi | 110606 |
Genome annotation databases
Ensembli | ENSMUST00000041008; ENSMUSP00000035498; ENSMUSG00000033373 |
GeneIDi | 110606 |
KEGGi | mmu:110606 |
UCSCi | uc007nyu.1, mouse |
Organism-specific databases
CTDi | 2342 |
MGIi | MGI:1861305, Fntb |
VEuPathDBi | HostDB:ENSMUSG00000033373 |
Phylogenomic databases
eggNOGi | KOG0365, Eukaryota |
GeneTreei | ENSGT00950000183128 |
HOGENOMi | CLU_028946_0_1_1 |
InParanoidi | Q8K2I1 |
OMAi | THPLFNI |
OrthoDBi | 1042804at2759 |
PhylomeDBi | Q8K2I1 |
TreeFami | TF353162 |
Enzyme and pathway databases
Reactomei | R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 110606, 27 hits in 70 CRISPR screens |
ChiTaRSi | Fntb, mouse |
PROi | PR:Q8K2I1 |
RNActi | Q8K2I1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033373, Expressed in brain and 260 other tissues |
ExpressionAtlasi | Q8K2I1, baseline and differential |
Genevisiblei | Q8K2I1, MM |
Family and domain databases
CDDi | cd02893, FTase, 1 hit |
InterProi | View protein in InterPro IPR026872, FTB IPR001330, PFTB_repeat IPR045089, PGGT1B-like IPR008930, Terpenoid_cyclase/PrenylTrfase |
PANTHERi | PTHR11774, PTHR11774, 1 hit PTHR11774:SF6, PTHR11774:SF6, 1 hit |
Pfami | View protein in Pfam PF00432, Prenyltrans, 5 hits |
SUPFAMi | SSF48239, SSF48239, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FNTB_MOUSE | |
Accessioni | Q8K2I1Primary (citable) accession number: Q8K2I1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families