Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein LSM14 homolog A

Gene

Lsm14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.By similarity

GO - Molecular functioni

  • double-stranded DNA binding Source: MGI
  • double-stranded RNA binding Source: MGI
  • single-stranded RNA binding Source: MGI

GO - Biological processi

  • cytoplasmic mRNA processing body assembly Source: UniProtKB
  • defense response to virus Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of type I interferon-mediated signaling pathway Source: MGI
  • regulation of translation Source: UniProtKB-KW
  • RIG-I signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein, Repressor, Ribonucleoprotein
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LSM14 homolog A
Alternative name(s):
Protein FAM61A
RNA-associated protein 55A
Short name:
mRAP55A
Gene namesi
Name:Lsm14a
Synonyms:Fam61a, Rap55a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914320 Lsm14a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001870912 – 462Protein LSM14 homolog AAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei194PhosphothreonineBy similarity1
Modified residuei216PhosphoserineCombined sources1
Modified residuei227PhosphoserineBy similarity1
Modified residuei400Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8K2F8
MaxQBiQ8K2F8
PaxDbiQ8K2F8
PeptideAtlasiQ8K2F8
PRIDEiQ8K2F8

PTM databases

iPTMnetiQ8K2F8
PhosphoSitePlusiQ8K2F8

Expressioni

Gene expression databases

BgeeiENSMUSG00000066568
CleanExiMM_LSM14A
ExpressionAtlasiQ8K2F8 baseline and differential
GenevisibleiQ8K2F8 MM

Interactioni

Subunit structurei

Component of a ribonucleoprotein (RNP) complex.By similarity

Protein-protein interaction databases

BioGridi211917, 7 interactors
IntActiQ8K2F8, 5 interactors
STRINGi10090.ENSMUSP00000082723

Structurei

3D structure databases

ProteinModelPortaliQ8K2F8
SMRiQ8K2F8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 319DFDFPROSITE-ProRule annotationAdd BLAST37

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi360 – 376FFD boxAdd BLAST17
Motifi379 – 399TFG boxAdd BLAST21

Domaini

The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention.By similarity

Sequence similaritiesi

Belongs to the LSM14 family.Curated

Phylogenomic databases

eggNOGiKOG1073 Eukaryota
ENOG41122RA LUCA
GeneTreeiENSGT00390000004174
HOGENOMiHOG000231251
HOVERGENiHBG054326
InParanoidiQ8K2F8
KOiK18749
OMAiEWRGEEQ
OrthoDBiEOG091G0FJG
PhylomeDBiQ8K2F8
TreeFamiTF313514

Family and domain databases

CDDicd01736 LSm14_N, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025761 FFD_box
IPR025609 Lsm14-like_N
IPR010920 LSM_dom_sf
IPR025768 TFG_box
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51513 FFD, 1 hit
PS51536 TFG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K2F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGGTPYIGS KISLISKAEI RYEGILYTID TENSTVALAK VRSFGTEDRP
60 70 80 90 100
TDRPIPPRDE VFEYIIFRGS DIKDLTVCEP PKPQCSLPQD PAIVQSSLGS
110 120 130 140 150
SSSSFQSVGS YGPFGRMPAY SQFSPSTLVG QQFGAVGVAG NSLTSFGTEA
160 170 180 190 200
SNSGTLSQSN AVGSAFTQDT RSVKPQLAQG RSSPQLDPLR KSPTMEQAVQ
210 220 230 240 250
TASAHLPAPA PVGRRSPVPA RPLPPTSQKA IDNQEHRRAE VHKVPRPENE
260 270 280 290 300
QLRNDKRQVV PGVPSAPRRG RGGHRGGRGR FGIRRDGPMK FEKDFDFESA
310 320 330 340 350
NAQFNKEEID REFHNKLKLK EDKLEKQEKP VNGEDKGDSG VDTQNSEGNA
360 370 380 390 400
DEEDPLGPNC YYDKTKSFFD NISCDDNRER RPTWAEERRL NAETFGIPLR
410 420 430 440 450
PNRGRGGYRG RGGLGFRGGR GRGSGRGGTF TAPRGFRAGF RGARGGREFA
460
DFEYRKTTAF GP
Length:462
Mass (Da):50,546
Last modified:October 1, 2002 - v1
Checksum:iB2554A73B96C473B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031521 mRNA Translation: AAH31521.1
AK003611 mRNA Translation: BAB22889.1
CCDSiCCDS21140.1
RefSeqiNP_080224.1, NM_025948.2
UniGeneiMm.276503

Genome annotation databases

EnsembliENSMUST00000085585; ENSMUSP00000082723; ENSMUSG00000066568
GeneIDi67070
KEGGimmu:67070
UCSCiuc009gjd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLS14A_MOUSE
AccessioniPrimary (citable) accession number: Q8K2F8
Secondary accession number(s): Q9CTG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health