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UniProtKB - Q8K2F0 (BRD3_MOUSE)

Entry version 143 (25 May 2022)
Sequence version 2 (10 May 2004)
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Protein

Bromodomain-containing protein 3

Gene

Brd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:21536911).

Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (PubMed:21536911).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain-containing protein 3
Alternative name(s):
Bromodomain-containing FSH-like protein FSRG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brd3
Synonyms:Fsrg2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914632, Brd3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000026918

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002111821 – 726Bromodomain-containing protein 3Add BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineCombined sources1
Modified residuei280PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei564PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8K2F0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8K2F0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8K2F0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8K2F0

PRoteomics IDEntifications database

More...PRIDEi		Q8K2F0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		273760 [Q8K2F0-1]
273761 [Q8K2F0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8K2F0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8K2F0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026918, Expressed in undifferentiated genital tubercle and 306 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8K2F0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8K2F0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro) (PubMed:21536911).

Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315' (PubMed:21555453).

Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (PubMed:21555453).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212148, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028282

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8K2F0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1726
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8K2F0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8K2F0

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8K2F0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 122Bromo 1PROSITE-ProRule annotationAdd BLAST73
Domaini325 – 397Bromo 2PROSITE-ProRule annotationAdd BLAST73
Domaini563 – 645NETPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni77 – 79Acetylated histone H3 bindingBy similarity3
Regioni147 – 172DisorderedSequence analysisAdd BLAST26
Regioni236 – 308DisorderedSequence analysisAdd BLAST73
Regioni418 – 576DisorderedSequence analysisAdd BLAST159
Regioni638 – 726DisorderedSequence analysisAdd BLAST89

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili452 – 482Sequence analysisAdd BLAST31
Coiled coili646 – 689Sequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 28Pro residuesSequence analysisAdd BLAST16
Compositional biasi246 – 265Polar residuesSequence analysisAdd BLAST20
Compositional biasi272 – 308Basic and acidic residuesSequence analysisAdd BLAST37
Compositional biasi434 – 448Polar residuesSequence analysisAdd BLAST15
Compositional biasi451 – 468Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi497 – 525Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi535 – 557Polar residuesSequence analysisAdd BLAST23
Compositional biasi653 – 674Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi696 – 726Polar residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Bromo domains specifically recognize and bind acetylated histones.By similarity

Keywords - Domaini

Bromodomain, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1474, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153385

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8K2F0

Identification of Orthologs from Complete Genome Data

More...OMAi		CYAFNPD

TreeFam database of animal gene trees

More...TreeFami		TF317345

Family and domain databases

Conserved Domains Database

More...CDDi		cd05497, Bromo_Brdt_I_like, 1 hit
cd05498, Bromo_Brdt_II_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1270.220, 1 hit
1.20.920.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50153

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043508, Bromo_Brdt_I
IPR043509, Bromo_Brdt_II
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR027353, NET_dom
IPR038336, NET_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17035, BET, 1 hit
PF00439, Bromodomain, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00297, BROMO, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits
PS51525, NET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K2F0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTTAAAPTG IPAVPGPVNP PPPEVSNPSK PGRKTNQLQY MQNVVVKTLW 
        60         70         80         90        100
KHQFAWPFYQ PVDAIKLNLP DYHKIIKNPM DMGTIKKRLE NNYYWSASEC 
       110        120        130        140        150
MQDFNTMFTN CYIYNKPTDD IVLMAQALEK IFLQKVAQMP QEEVELLPPA 
       160        170        180        190        200
PKGKGRKPAA GAQNAGSQQV AAVSSVSPAT PFQNIPPTVS QTPVIAATPV 
       210        220        230        240        250
PTITANVTSV PVPPPAAPPP PATPIVPVVP PTPPVVKKKG VKRKADTTTP 
       260        270        280        290        300
TTSAITASRS ESPPPLSEPK QAKVVARRES GGRPIKPPKK DLEDGEVPQH 
       310        320        330        340        350
AGKKGKLSEH LRHCDSILRE MLSKKHAAYA WPFYKPVDAE ALELHDYHDI 
       360        370        380        390        400
IKHPMDLSTV KRKMDSREYP DAQGFAADIR LMFSNCYKYN PPDHEVVAMA 
       410        420        430        440        450
RKLQDVFEMR FAKMPDEPME APALPAPTAP IVSKGAESSR SSEESSSDSG 
       460        470        480        490        500
SSDSEEERAT RLAELQEQLK AVHEQLAALS QAPVNKPKKK KEKKEKEKKK 
       510        520        530        540        550
KDKDKDKEKE KHKAKSEEEK KAKAAPAAKQ AQQKKAPTKK ANSTTTASRQ 
       560        570        580        590        600
LKKGGKQASA SYDSEEEEEG LPMSYDEKRQ LSLDINRLPG EKLGRVVHII 
       610        620        630        640        650
QSREPSLRDS NPDEIEIDFE TLKPTTLREL ERYVKSCLQK KQRKPLSTSG 
       660        670        680        690        700
KKQAAKSKEE LAQEKKKELE KRLQDVSGQL NSKKPTKKEK SGSAPSGGPS 
       710        720 
RLSSSSSSES ASSSSSGSSS DSSDSE
Length:726
Mass (Da):79,762
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5B2FC0ACA41D8ED
GO
Isoform 2 (identifier: Q8K2F0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     468-468: Q → QTGCGAFQDQLLNVSSVQ

Show »
Length:743
Mass (Da):81,511
Checksum:iEA325174381A3737
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AKA9A2AKA9_MOUSE
Bromodomain-containing protein 3
Brd3
682Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AKB0A2AKB0_MOUSE
Bromodomain-containing protein 3
Brd3
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti174S → F in BAC36359 (PubMed:16141072).Curated1
Sequence conflicti216A → T in AAH31536 (PubMed:15489334).Curated1
Sequence conflicti477A → D in AAF78072 (Ref. 1) Curated1
Sequence conflicti659 – 660EE → VV in AAF78072 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010249468Q → QTGCGAFQDQLLNVSSVQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF269193 mRNA Translation: AAF78072.1
BC031536 mRNA Translation: AAH31536.1
AK037435 mRNA Translation: BAC29806.1
AK076472 mRNA Translation: BAC36359.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS15828.1 [Q8K2F0-1]
CCDS50546.1 [Q8K2F0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001107045.1, NM_001113573.1 [Q8K2F0-1]
NP_001107046.1, NM_001113574.1 [Q8K2F0-2]
NP_075825.3, NM_023336.4 [Q8K2F0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028282; ENSMUSP00000028282; ENSMUSG00000026918 [Q8K2F0-1]
ENSMUST00000077737; ENSMUSP00000076918; ENSMUSG00000026918 [Q8K2F0-1]
ENSMUST00000113941; ENSMUSP00000109574; ENSMUSG00000026918 [Q8K2F0-2]
ENSMUST00000164296; ENSMUSP00000128812; ENSMUSG00000026918 [Q8K2F0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67382

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67382

UCSC genome browser

More...UCSCi		uc008ixm.2, mouse [Q8K2F0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269193 mRNA Translation: AAF78072.1
BC031536 mRNA Translation: AAH31536.1
AK037435 mRNA Translation: BAC29806.1
AK076472 mRNA Translation: BAC36359.1
CCDSiCCDS15828.1 [Q8K2F0-1]
CCDS50546.1 [Q8K2F0-2]
RefSeqiNP_001107045.1, NM_001113573.1 [Q8K2F0-1]
NP_001107046.1, NM_001113574.1 [Q8K2F0-2]
NP_075825.3, NM_023336.4 [Q8K2F0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L5ENMR-A24-146[»]
AlphaFoldDBiQ8K2F0
SMRiQ8K2F0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi212148, 3 interactors
STRINGi10090.ENSMUSP00000028282

PTM databases

iPTMnetiQ8K2F0
PhosphoSitePlusiQ8K2F0

Proteomic databases

EPDiQ8K2F0
jPOSTiQ8K2F0
MaxQBiQ8K2F0
PaxDbiQ8K2F0
PRIDEiQ8K2F0
ProteomicsDBi273760 [Q8K2F0-1]
273761 [Q8K2F0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31966, 387 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		67382

Genome annotation databases

EnsembliENSMUST00000028282; ENSMUSP00000028282; ENSMUSG00000026918 [Q8K2F0-1]
ENSMUST00000077737; ENSMUSP00000076918; ENSMUSG00000026918 [Q8K2F0-1]
ENSMUST00000113941; ENSMUSP00000109574; ENSMUSG00000026918 [Q8K2F0-2]
ENSMUST00000164296; ENSMUSP00000128812; ENSMUSG00000026918 [Q8K2F0-1]
GeneIDi67382
KEGGimmu:67382
UCSCiuc008ixm.2, mouse [Q8K2F0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8019
MGIiMGI:1914632, Brd3
VEuPathDBiHostDB:ENSMUSG00000026918

Phylogenomic databases

eggNOGiKOG1474, Eukaryota
GeneTreeiENSGT00940000153385
InParanoidiQ8K2F0
OMAiCYAFNPD
TreeFamiTF317345

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67382, 1 hit in 77 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Brd3, mouse
EvolutionaryTraceiQ8K2F0

Protein Ontology

More...PROi		PR:Q8K2F0
RNActiQ8K2F0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026918, Expressed in undifferentiated genital tubercle and 306 other tissues
ExpressionAtlasiQ8K2F0, baseline and differential
GenevisibleiQ8K2F0, MM

Family and domain databases

CDDicd05497, Bromo_Brdt_I_like, 1 hit
cd05498, Bromo_Brdt_II_like, 1 hit
Gene3Di1.20.1270.220, 1 hit
1.20.920.10, 2 hits
IDEALiIID50153
InterProiView protein in InterPro
IPR043508, Bromo_Brdt_I
IPR043509, Bromo_Brdt_II
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR027353, NET_dom
IPR038336, NET_sf
PfamiView protein in Pfam
PF17035, BET, 1 hit
PF00439, Bromodomain, 2 hits
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00297, BROMO, 2 hits
SUPFAMiSSF47370, SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS00633, BROMODOMAIN_1, 2 hits
PS50014, BROMODOMAIN_2, 2 hits
PS51525, NET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRD3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K2F0
Secondary accession number(s): Q8C665, Q8CAX7, Q9JI25
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 25, 2022
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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