Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Enhancer of mRNA-decapping protein 3

Gene

Edc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: MGI
  • mRNA binding Source: GO_Central
  • phosphodiesterase decapping endonuclease activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Enhancer of mRNA-decapping protein 3
Alternative name(s):
YjeF domain-containing protein 1
Gene namesi
Name:Edc3
Synonyms:Yjdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2142951 Edc3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190561 – 508Enhancer of mRNA-decapping protein 3Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131PhosphoserineCombined sources1
Modified residuei138PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei161PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K2D3
MaxQBiQ8K2D3
PaxDbiQ8K2D3
PRIDEiQ8K2D3

PTM databases

iPTMnetiQ8K2D3
PhosphoSitePlusiQ8K2D3

Expressioni

Gene expression databases

BgeeiENSMUSG00000038957 Expressed in 237 organ(s), highest expression level in blastocyst
ExpressionAtlasiQ8K2D3 baseline and differential
GenevisibleiQ8K2D3 MM

Interactioni

Subunit structurei

Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237268, 1 interactor
IntActiQ8K2D3, 1 interactor
STRINGi10090.ENSMUSP00000049146

Structurei

3D structure databases

ProteinModelPortaliQ8K2D3
SMRiQ8K2D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 228DFDFPROSITE-ProRule annotationAdd BLAST37
Domaini283 – 487YjeF N-terminalPROSITE-ProRule annotationAdd BLAST205

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 79Required for P-body targeting and interaction with DCP1ABy similarityAdd BLAST79
Regioni191 – 296Required for interaction with DDX6By similarityAdd BLAST106

Domaini

The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity).By similarity

Sequence similaritiesi

Belongs to the EDC3 family.Curated

Phylogenomic databases

eggNOGiKOG2585 Eukaryota
COG0062 LUCA
GeneTreeiENSGT00390000016435
HOGENOMiHOG000231481
HOVERGENiHBG079428
InParanoidiQ8K2D3
KOiK12615
OMAiNERPARY
OrthoDBiEOG091G09C2
PhylomeDBiQ8K2D3
TreeFamiTF324695

Family and domain databases

CDDicd01737 LSm16_N, 1 hit
Gene3Di3.40.50.10260, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025609 Lsm14-like_N
IPR034107 Lsm16_N
IPR004443 YjeF_N_dom
IPR036652 YjeF_N_dom_sf
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
PF03853 YjeF_N, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF64153 SSF64153, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51385 YJEF_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K2D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMDWLGSIV SINCGDSLGV YQGRVSAVDQ VSQTISLTRP FHNGVKCLVP
60 70 80 90 100
EVTFRAGDIT ELKILEIPGP GDNQQVGDLH QTELGPSGVG YQMSISQNGT
110 120 130 140 150
GKVVKKPASS SSAPQSIPKR TDVKSQDVAI SPQQQQCSKS YVDRHMESLS
160 170 180 190 200
QSKSFRRRHN SWSSSSRHPN QATPKKSGLK NGQMKNKDDE CFGDDIEELP
210 220 230 240 250
DTDFDFEGNL ALFDKAAVFE EIDTYERRSG SRSRGVPNER PARYRHDENI
260 270 280 290 300
LESEPIVYRR ITVPHSVSKE FCTDSGLVVP SVSYELHKKL LSVAEKHGLT
310 320 330 340 350
LERRLEMTGV CASQMALTLL GGPNRLNPKN VHQRPTVALL CGPHVKGAQG
360 370 380 390 400
ISCGRHLANH DVQVILFLPN FVKMLESITN ELSLFSKTQG QQVSSLRDLP
410 420 430 440 450
ASPVDLVINC LDCPENAFLR DQPWYKAAVA WANQNRAPVL SIDPPVHEVE
460 470 480 490 500
QGIDAKWSLA LGLPLPLGEH AGRVYLCDIG IPQQVFQEVG INYHSPFGCK

FVIPLHSA
Length:508
Mass (Da):55,957
Last modified:October 1, 2002 - v1
Checksum:iDD1F449BEF1341C8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCX6D6RCX6_MOUSE
Enhancer of mRNA-decapping protein ...
Edc3
57Annotation score:
D3YYS4D3YYS4_MOUSE
Enhancer of mRNA-decapping protein ...
Edc3
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237P → T in BAE40089 (PubMed:16141072).Curated1
Sequence conflicti333Q → R in BAE40089 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146804 mRNA Translation: BAE27445.1
AK166286 mRNA Translation: BAE38683.1
AK168118 mRNA Translation: BAE40089.1
BC031725 mRNA Translation: AAH31725.1
BC033484 mRNA Translation: AAH33484.1
CCDSiCCDS23231.1
RefSeqiNP_722494.1, NM_153799.3
XP_011241062.1, XM_011242760.2
UniGeneiMm.268104

Genome annotation databases

EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957
GeneIDi353190
KEGGimmu:353190
UCSCiuc009pvp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146804 mRNA Translation: BAE27445.1
AK166286 mRNA Translation: BAE38683.1
AK168118 mRNA Translation: BAE40089.1
BC031725 mRNA Translation: AAH31725.1
BC033484 mRNA Translation: AAH33484.1
CCDSiCCDS23231.1
RefSeqiNP_722494.1, NM_153799.3
XP_011241062.1, XM_011242760.2
UniGeneiMm.268104

3D structure databases

ProteinModelPortaliQ8K2D3
SMRiQ8K2D3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237268, 1 interactor
IntActiQ8K2D3, 1 interactor
STRINGi10090.ENSMUSP00000049146

PTM databases

iPTMnetiQ8K2D3
PhosphoSitePlusiQ8K2D3

Proteomic databases

EPDiQ8K2D3
MaxQBiQ8K2D3
PaxDbiQ8K2D3
PRIDEiQ8K2D3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043990; ENSMUSP00000049146; ENSMUSG00000038957
GeneIDi353190
KEGGimmu:353190
UCSCiuc009pvp.1 mouse

Organism-specific databases

CTDi80153
MGIiMGI:2142951 Edc3

Phylogenomic databases

eggNOGiKOG2585 Eukaryota
COG0062 LUCA
GeneTreeiENSGT00390000016435
HOGENOMiHOG000231481
HOVERGENiHBG079428
InParanoidiQ8K2D3
KOiK12615
OMAiNERPARY
OrthoDBiEOG091G09C2
PhylomeDBiQ8K2D3
TreeFamiTF324695

Enzyme and pathway databases

ReactomeiR-MMU-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

ChiTaRSiEdc3 mouse
PROiPR:Q8K2D3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038957 Expressed in 237 organ(s), highest expression level in blastocyst
ExpressionAtlasiQ8K2D3 baseline and differential
GenevisibleiQ8K2D3 MM

Family and domain databases

CDDicd01737 LSm16_N, 1 hit
Gene3Di3.40.50.10260, 1 hit
InterProiView protein in InterPro
IPR025762 DFDF
IPR019050 FDF_dom
IPR025609 Lsm14-like_N
IPR034107 Lsm16_N
IPR004443 YjeF_N_dom
IPR036652 YjeF_N_dom_sf
PfamiView protein in Pfam
PF09532 FDF, 1 hit
PF12701 LSM14, 1 hit
PF03853 YjeF_N, 1 hit
SMARTiView protein in SMART
SM01199 FDF, 1 hit
SM01271 LSM14, 1 hit
SUPFAMiSSF64153 SSF64153, 1 hit
PROSITEiView protein in PROSITE
PS51512 DFDF, 1 hit
PS51385 YJEF_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEDC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K2D3
Secondary accession number(s): Q3THV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again