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Protein

Protein OS-9

Gene

Os9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130CarbohydrateBy similarity1
Binding sitei182CarbohydrateBy similarity1
Binding sitei188CarbohydrateBy similarity1
Binding sitei212CarbohydrateBy similarity1
Binding sitei218CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-901032 ER Quality Control Compartment (ERQC)

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9
Gene namesi
Name:Os9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1924301 Os9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000038644927 – 672Protein OS-9Add BLAST646

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 123By similarity
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi181 ↔ 216By similarity
Disulfide bondi196 ↔ 228By similarity

Post-translational modificationi

Intramolecular disulfide bonds.By similarity
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8K2C7
PaxDbiQ8K2C7
PeptideAtlasiQ8K2C7
PRIDEiQ8K2C7

PTM databases

iPTMnetiQ8K2C7
PhosphoSitePlusiQ8K2C7

Expressioni

Gene expression databases

BgeeiENSMUSG00000040462 Expressed in 314 organ(s), highest expression level in lacrimal gland
ExpressionAtlasiQ8K2C7 baseline and differential
GenevisibleiQ8K2C7 MM

Interactioni

Subunit structurei

Probably part of the HRD1 ubiquitin ligase complex composed at least of SYVN1/HRD1 and SEL1L with which it interacts directly. Through this complex it may interact with ERLEC1 and HSPA5. Interacts with DERL2. Interacts with HSP90B1, CREB3 and SYVN1 (By similarity). Interacts (via C-terminus) with CPNE6 (via second C2 domain); this interaction occurs in a calcium-dependent manner in vitro (PubMed:10403379).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229745, 3 interactors
IntActiQ8K2C7, 3 interactors
MINTiQ8K2C7
STRINGi10090.ENSMUSP00000128914

Structurei

3D structure databases

ProteinModelPortaliQ8K2C7
SMRiQ8K2C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 178PRKCSHAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi412 – 434Asp/Glu-rich (acidic)Add BLAST23

Sequence similaritiesi

Belongs to the OS-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
HOGENOMiHOG000293348
InParanoidiQ8K2C7
KOiK10088
OMAiFQNNVQV
OrthoDBiEOG091G02WQ
PhylomeDBiQ8K2C7
TreeFamiTF314309

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K2C7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAEVLLSSL LGLLFLGLLL PARLTGGVGS LNLEELSEMR YGIQILPLPV
60 70 80 90 100
MGGQSQASDV VVVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE
110 120 130 140 150
LLSPMRDAPC LLKTKDWWTY EFCYGRHIQQ YHMEDSEIKG DVLYLGHYQS
160 170 180 190 200
SFNWDDETAK ASKQHRLKRY HSQTYGNGSK CDLNGKPREA EVRFLCDEGA
210 220 230 240 250
GISGDYIDRV DEPVSCSYVL TIRTSRLCPH PLLRPPASAA PQAILCHPAL
260 270 280 290 300
QPDEYMAYLQ RQAESKQHEE KTTEEVQDTD RQVWSGSKAA GAPPKKEDVS
310 320 330 340 350
PAKEEKESEL WKLQGPEEQA AAREEAQAGE QDLNHEAAAD PAPSPPNDFQ
360 370 380 390 400
NNVQVKLIRS PADLIRLIEE LKAAEKGKPS VRREQPGDDT TEAPQREAEG
410 420 430 440 450
TKAKGKDGEP PGLMEEEDGD DEEEEEEEEE DEEEQQLLGE FEKELEGMLL
460 470 480 490 500
PSNRERLRSE VKAGMERELE NIIQETEKEL DPEGLRKESE REQAILALTS
510 520 530 540 550
TLDKLIKRLQ ENQSPELVQK YKKRRVVPQK PPPSPHPTEE EPEHRVRVRV
560 570 580 590 600
TKLRPGGPNR DLTVLEMNRE NPQLKQIEGL VTEVLEREGL TAEGKIEIKI
610 620 630 640 650
VRPGAEGKEE DTRWLTDEDT RNLKEIFFNI LVQGAEEANK ERQRQSELES
660 670
NYRRVWGSPG GEDTGDLDEF DF
Length:672
Mass (Da):76,108
Last modified:October 13, 2009 - v2
Checksum:i7320981E721A9686
GO
Isoform 2 (identifier: Q8K2C7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     539-593: Missing.

Show »
Length:617
Mass (Da):69,764
Checksum:iEC224EA8A3C07E8D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6Z8A0A1W2P6Z8_MOUSE
Protein OS-9
Os9
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407D → G in AAH31768 (PubMed:15489334).Curated1
Sequence conflicti453N → D in AAH31768 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038220539 – 593Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131760 Genomic DNA No translation available.
BC031768 mRNA Translation: AAH31768.1
CCDSiCCDS24229.1 [Q8K2C7-2]
CCDS48713.1 [Q8K2C7-1]
RefSeqiNP_001164497.1, NM_001171026.1 [Q8K2C7-1]
NP_808282.2, NM_177614.3 [Q8K2C7-2]
UniGeneiMm.295246
Mm.403598

Genome annotation databases

EnsembliENSMUST00000080975; ENSMUSP00000079770; ENSMUSG00000040462 [Q8K2C7-2]
ENSMUST00000164259; ENSMUSP00000128914; ENSMUSG00000040462 [Q8K2C7-1]
GeneIDi216440
KEGGimmu:216440
UCSCiuc007hhz.2 mouse [Q8K2C7-2]
uc007hia.2 mouse [Q8K2C7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131760 Genomic DNA No translation available.
BC031768 mRNA Translation: AAH31768.1
CCDSiCCDS24229.1 [Q8K2C7-2]
CCDS48713.1 [Q8K2C7-1]
RefSeqiNP_001164497.1, NM_001171026.1 [Q8K2C7-1]
NP_808282.2, NM_177614.3 [Q8K2C7-2]
UniGeneiMm.295246
Mm.403598

3D structure databases

ProteinModelPortaliQ8K2C7
SMRiQ8K2C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229745, 3 interactors
IntActiQ8K2C7, 3 interactors
MINTiQ8K2C7
STRINGi10090.ENSMUSP00000128914

PTM databases

iPTMnetiQ8K2C7
PhosphoSitePlusiQ8K2C7

Proteomic databases

EPDiQ8K2C7
PaxDbiQ8K2C7
PeptideAtlasiQ8K2C7
PRIDEiQ8K2C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080975; ENSMUSP00000079770; ENSMUSG00000040462 [Q8K2C7-2]
ENSMUST00000164259; ENSMUSP00000128914; ENSMUSG00000040462 [Q8K2C7-1]
GeneIDi216440
KEGGimmu:216440
UCSCiuc007hhz.2 mouse [Q8K2C7-2]
uc007hia.2 mouse [Q8K2C7-1]

Organism-specific databases

CTDi10956
MGIiMGI:1924301 Os9

Phylogenomic databases

eggNOGiKOG3394 Eukaryota
ENOG410XR8A LUCA
GeneTreeiENSGT00530000063603
HOGENOMiHOG000293348
InParanoidiQ8K2C7
KOiK10088
OMAiFQNNVQV
OrthoDBiEOG091G02WQ
PhylomeDBiQ8K2C7
TreeFamiTF314309

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

PROiPR:Q8K2C7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040462 Expressed in 314 organ(s), highest expression level in lacrimal gland
ExpressionAtlasiQ8K2C7 baseline and differential
GenevisibleiQ8K2C7 MM

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOS9_MOUSE
AccessioniPrimary (citable) accession number: Q8K2C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 12, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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