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Protein

F-BAR domain only protein 1

Gene

Fcho1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity).By similarity

GO - Molecular functioni

  • AP-2 adaptor complex binding Source: MGI
  • cytoskeletal protein binding Source: GO_Central
  • microtubule binding Source: GO_Central
  • phospholipid binding Source: GO_Central
  • tubulin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
F-BAR domain only protein 1
Gene namesi
Name:Fcho1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921265 Fcho1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717601 – 873F-BAR domain only protein 1Add BLAST873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei368PhosphoserineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei600PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K285
MaxQBiQ8K285
PaxDbiQ8K285
PRIDEiQ8K285

PTM databases

iPTMnetiQ8K285
PhosphoSitePlusiQ8K285

Expressioni

Tissue specificityi

Mainly detected in brain and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000070000 Expressed in 149 organ(s), highest expression level in thymus
CleanExiMM_FCHO1
ExpressionAtlasiQ8K285 baseline and differential
GenevisibleiQ8K285 MM

Interactioni

Subunit structurei

May oligomerize and form homotetramer. Interacts with AP2A2 and AP2B1; 2 subunits of the adaptor protein complex AP-2. Interacts with DAB2 (By similarity). Interacts with clathrin (CLTC or CLTCL1) (By similarity). Interacts with EPS15, EPS15R and ITSN1 (By similarity). Interacts with AGFG1 and CALM (By similarity). May interact with ACVR1; linking this receptor to clathrin-mediated endocytosis (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Necap1Q9CR952EBI-16078916,EBI-7592476

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216425, 3 interactors
DIPiDIP-60611N
IntActiQ8K285, 1 interactor
STRINGi10090.ENSMUSP00000091151

Structurei

3D structure databases

ProteinModelPortaliQ8K285
SMRiQ8K285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 248F-BARPROSITE-ProRule annotationAdd BLAST248
Domaini609 – 872MHDPROSITE-ProRule annotationAdd BLAST264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 275Mediates membrane-bindingBy similarityAdd BLAST275
Regioni267 – 439Mediates interaction with the adaptor protein complex AP-2By similarityAdd BLAST173
Regioni593 – 873Mediates interaction with AGFG1, CALM, DAB2, EPS15, EPS15R, ITSN1 and clathrinBy similarityAdd BLAST281

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 178Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the FCHO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IU8F Eukaryota
ENOG410ZN1N LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000231544
HOVERGENiHBG081524
InParanoidiQ8K285
KOiK20042
OMAiTAPIEHF
OrthoDBiEOG091G0AB1
PhylomeDBiQ8K285
TreeFamiTF328986

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR028565 MHD
IPR018808 Muniscin_C
PANTHERiPTHR23065:SF6 PTHR23065:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8K285-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYFGEHFWG DKNHGFEVLY HCVKQGPVAT KELADFIRER ANIEETYSKA
60 70 80 90 100
MAKLSKLASN GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLHDLLKDVL
110 120 130 140 150
RYGEEQLKTH KKCKEEVLGT VDAVQMLSGV GQLLPKSREN YLSRCMDLER
160 170 180 190 200
LRRENTSQKE MDKAETKSKK AADSLRRSVD KYNSARADFE IKMLDSALRF
210 220 230 240 250
QAMEEAHLQH MKALLGSYAH SVEDTHVQIG QVHEEFKQNV ENVTVDMLLR
260 270 280 290 300
KFAESKGTGR EKPGPLDFDA YSSAALQEAM KRLRGAKAFR LPGLSRREPR
310 320 330 340 350
ASVDFLESDS GVPPEVDDEG FTVRPDISQN NGAEPPRFSS SDSDFDDEEP
360 370 380 390 400
RKFYVHIKPA PTRAVACSSE AAAAQLRATA GSLILPPGPG GTMKRHSSRD
410 420 430 440 450
TSGKPQRPRS APRTGSCAEK PLASEEPLSK SLFGPPLESA FDHDDFTGSS
460 470 480 490 500
SLGFTSSPSP FSSSSPENVE DSGLDSPSHA APGPSPESWV PRPGTPQSPP
510 520 530 540 550
TCRAQHPEPR GLMPRAPSPG PWGPEGGADS LTPADPTREG LAATLRRPRS
560 570 580 590 600
RKVSCPLTRS NGDLCRSLSP SPLGSSAPTI PPDRPSFSTQ MGHGISRGPS
610 620 630 640 650
PVVLGSQDAL PVATAFTEYV HAYFRGHSPS CLARVTGELT MTFPAGIVRV
660 670 680 690 700
FSGTPPPPVL SFRLVNTAPV EHFQPNADLI FSDPSQSDPE TKDFWLNMAA
710 720 730 740 750
LTEALQHQAE QNPTASYYNL VLLRYQFSRP GPESVPLQMS AHWQCGPTLT
760 770 780 790 800
RVSVEYSYRA GATAVSTPLT NVQILLPVGE PVTSVRLQPA ATWNTEEKRF
810 820 830 840 850
TWKLPDVCEA GGSGHLSASW QPQSGPSTPS PVAAQFTSEG ATLSGLDLEL
860 870
LGGGYRMSLV KRRFATGMYL VSC
Length:873
Mass (Da):95,122
Last modified:July 27, 2011 - v2
Checksum:iE0D2549EF2A5C020
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCG0D6RCG0_MOUSE
F-BAR domain only protein 1
Fcho1
304Annotation score:
D3Z6N2D3Z6N2_MOUSE
F-BAR domain only protein 1
Fcho1
203Annotation score:
D3YYE9D3YYE9_MOUSE
F-BAR domain only protein 1
Fcho1
87Annotation score:
F6VQ30F6VQ30_MOUSE
F-BAR domain only protein 1
Fcho1
84Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti609A → T in AAH32207 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162033 Genomic DNA No translation available.
BC032207 mRNA Translation: AAH32207.1
CCDSiCCDS52588.1
RefSeqiNP_082991.3, NM_028715.3
XP_006509828.1, XM_006509765.2
XP_006509829.1, XM_006509766.3
XP_006509830.1, XM_006509767.3
UniGeneiMm.22025

Genome annotation databases

EnsembliENSMUST00000093444; ENSMUSP00000091151; ENSMUSG00000070000
ENSMUST00000146100; ENSMUSP00000117606; ENSMUSG00000070000
GeneIDi74015
KEGGimmu:74015
UCSCiuc033jge.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162033 Genomic DNA No translation available.
BC032207 mRNA Translation: AAH32207.1
CCDSiCCDS52588.1
RefSeqiNP_082991.3, NM_028715.3
XP_006509828.1, XM_006509765.2
XP_006509829.1, XM_006509766.3
XP_006509830.1, XM_006509767.3
UniGeneiMm.22025

3D structure databases

ProteinModelPortaliQ8K285
SMRiQ8K285
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216425, 3 interactors
DIPiDIP-60611N
IntActiQ8K285, 1 interactor
STRINGi10090.ENSMUSP00000091151

PTM databases

iPTMnetiQ8K285
PhosphoSitePlusiQ8K285

Proteomic databases

EPDiQ8K285
MaxQBiQ8K285
PaxDbiQ8K285
PRIDEiQ8K285

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093444; ENSMUSP00000091151; ENSMUSG00000070000
ENSMUST00000146100; ENSMUSP00000117606; ENSMUSG00000070000
GeneIDi74015
KEGGimmu:74015
UCSCiuc033jge.1 mouse

Organism-specific databases

CTDi23149
MGIiMGI:1921265 Fcho1

Phylogenomic databases

eggNOGiENOG410IU8F Eukaryota
ENOG410ZN1N LUCA
GeneTreeiENSGT00930000150876
HOGENOMiHOG000231544
HOVERGENiHBG081524
InParanoidiQ8K285
KOiK20042
OMAiTAPIEHF
OrthoDBiEOG091G0AB1
PhylomeDBiQ8K285
TreeFamiTF328986

Enzyme and pathway databases

ReactomeiR-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:Q8K285
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070000 Expressed in 149 organ(s), highest expression level in thymus
CleanExiMM_FCHO1
ExpressionAtlasiQ8K285 baseline and differential
GenevisibleiQ8K285 MM

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR030121 FCHo1
IPR028565 MHD
IPR018808 Muniscin_C
PANTHERiPTHR23065:SF6 PTHR23065:SF6, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF10291 muHD, 1 hit
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS51072 MHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFCHO1_MOUSE
AccessioniPrimary (citable) accession number: Q8K285
Secondary accession number(s): D3Z3Q5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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