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Protein

E3 ubiquitin-protein ligase TRIM68

Gene

Trim68

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri93 – 134B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM68 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 137
RING-type E3 ubiquitin transferase TRIM68Curated
Tripartite motif-containing protein 68
Gene namesi
Name:Trim68
Synonyms:Rnf137
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142077 Trim68

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002494381 – 485E3 ubiquitin-protein ligase TRIM68Add BLAST485

Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8K243
PaxDbiQ8K243
PRIDEiQ8K243

PTM databases

iPTMnetiQ8K243
PhosphoSitePlusiQ8K243

Expressioni

Gene expression databases

CleanExiMM_TRIM68

Interactioni

Subunit structurei

Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8K243
SMRiQ8K243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 483B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili144 – 226Sequence analysisAdd BLAST83

Domaini

The RING domain is essential for ubiquitin E3 ligase activity.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 61RING-typePROSITE-ProRule annotationAdd BLAST46
Zinc fingeri93 – 134B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ8K243
PhylomeDBiQ8K243

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPAVLMEAI VEEVNCPICM TFLREPVSIS CGHTFCHSCL SGLWKLPGES
60 70 80 90 100
QNLSYTCPLC RAPVKPRKLR PNWQLASVVD KVRLLGFCME MGLKTDVCDL
110 120 130 140 150
HKEQLTMFCK EDDMVTCEAC KQSPEHEAHS VVPIKDVAWE YKWKLQQALE
160 170 180 190 200
HLRKEQEEAW KLEVSEKEQA AIWKTQMERR KQSIRWEFEK YRQLLKEKEL
210 220 230 240 250
PCQQAEEEAA AAQASLEQEK GETASKLELR REAIIRQSQV LWSMIVELEE
260 270 280 290 300
RSQRPVRWML QGIQEALNRS ESWTLQQLEP ISLELKTDCR VLGLRETLKT
310 320 330 340 350
FAVDVRLDPD TAYSRLVVSK DRKSVHYGVT QQNLPDNPER FYRYNIVLGS
360 370 380 390 400
QCISSGRHYW EVEVGDRSEW GLGVCVENVD RKEVVYLSPR YGFWVIRLRK
410 420 430 440 450
GTEYRAGTDE YPLLPLTVPP HRVGIFLDYE AHDISFYNVT DGASHIFTFP
460 470 480
CYPFPGRLLP YFSPCYSIDT NNTTPLTICT LGGEG
Length:485
Mass (Da):56,098
Last modified:October 1, 2002 - v1
Checksum:i8F5428A3FDB4857D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9I6G3X9I6_MOUSE
E3 ubiquitin-protein ligase TRIM68
Trim68 mCG_23411
485Annotation score:
A0A1B0GSL9A0A1B0GSL9_MOUSE
E3 ubiquitin-protein ligase TRIM68
Trim68
327Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034249 mRNA Translation: AAH34249.1
CCDSiCCDS40052.1
UniGeneiMm.39043

Genome annotation databases

UCSCiuc009isg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034249 mRNA Translation: AAH34249.1
CCDSiCCDS40052.1
UniGeneiMm.39043

3D structure databases

ProteinModelPortaliQ8K243
SMRiQ8K243
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8K243
PhosphoSitePlusiQ8K243

Proteomic databases

MaxQBiQ8K243
PaxDbiQ8K243
PRIDEiQ8K243

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009isg.2 mouse

Organism-specific databases

MGIiMGI:2142077 Trim68

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
HOGENOMiHOG000234133
HOVERGENiHBG001357
InParanoidiQ8K243
PhylomeDBiQ8K243

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

PROiPR:Q8K243
SOURCEiSearch...

Gene expression databases

CleanExiMM_TRIM68

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI68_MOUSE
AccessioniPrimary (citable) accession number: Q8K243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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