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Protein

Arfaptin-2

Gene

Arfip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Arfaptin-2
Alternative name(s):
ADP-ribosylation factor-interacting protein 2
Gene namesi
Name:Arfip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924182 Arfip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646681 – 341Arfaptin-2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei72PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K221
MaxQBiQ8K221
PaxDbiQ8K221
PeptideAtlasiQ8K221
PRIDEiQ8K221

PTM databases

iPTMnetiQ8K221
PhosphoSitePlusiQ8K221

Expressioni

Gene expression databases

BgeeiENSMUSG00000030881 Expressed in 280 organ(s), highest expression level in pancreas
CleanExiMM_ARFIP2
ExpressionAtlasiQ8K221 baseline and differential
GenevisibleiQ8K221 MM

Interactioni

Subunit structurei

Interacts with RAC1 by binding directly to it. Specifically binds to GTP-bound ARF1 and ARF6, but binds to RAC1.GTP and RAC1.GDP with similar affinities (By similarity). Directly interacts with ARL1 GTP-bound form; this interaction leads to an increase in the amount of bound GTP at steady state level (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218408, 1 interactor
IntActiQ8K221, 2 interactors
MINTiQ8K221
STRINGi10090.ENSMUSP00000081840

Structurei

3D structure databases

ProteinModelPortaliQ8K221
SMRiQ8K221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 321AHPROSITE-ProRule annotationAdd BLAST201

Phylogenomic databases

eggNOGiKOG3876 Eukaryota
ENOG410YJUM LUCA
GeneTreeiENSGT00500000044828
HOGENOMiHOG000236308
HOVERGENiHBG050564
InParanoidiQ8K221
KOiK20314
OMAiHRDKYER
OrthoDBiEOG091G0H30
PhylomeDBiQ8K221
TreeFamiTF314945

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030798 Arfaptin_fam
PANTHERiPTHR12141 PTHR12141, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8K221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDGILGKAA TMEIPIHGNG EAGQLPEDDG LEQDLQQVMV SGPNLNETSI
60 70 80 90 100
VSGGYGGSGD GLIPTGSGRH PSHSTSPSGP GDEVARGIAG EKFDIVKKWG
110 120 130 140 150
INTYKCTKQL LSERFGRGSR TVDLELELQI ELLRETKRKY ESVLQLGRAL
160 170 180 190 200
TAHLYSLLQT QHALGDAFAD LSQKSPELQE EFGYNAETQK LLCKNGETLL
210 220 230 240 250
GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT DLEELSLGPR
260 270 280 290 300
DAGTRGRLES AQATFQTHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL
310 320 330 340
FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q
Length:341
Mass (Da):37,773
Last modified:June 7, 2005 - v2
Checksum:iAA3BE39EF0C75037
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSM3A0A1B0GSM3_MOUSE
ADP-ribosylation factor interacting...
Arfip2 mCG_19713
267Annotation score:
A0A1B0GS63A0A1B0GS63_MOUSE
ADP-ribosylation factor interacting...
Arfip2 mCG_19713
337Annotation score:
D3Z2F3D3Z2F3_MOUSE
Arfaptin-2
Arfip2
209Annotation score:
D6RHM6D6RHM6_MOUSE
Arfaptin-2
Arfip2
159Annotation score:
A0A1B0GQY8A0A1B0GQY8_MOUSE
Arfaptin-2
Arfip2
111Annotation score:
D6RI79D6RI79_MOUSE
Arfaptin-2
Arfip2
51Annotation score:
H7BWZ6H7BWZ6_MOUSE
Arfaptin-2
Arfip2
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107T → K in AAH34520 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009100 mRNA Translation: BAB26070.1
AK154772 mRNA Translation: BAE32820.1
BC013794 mRNA Translation: AAH13794.1
BC022942 mRNA Translation: AAH22942.1
BC034520 mRNA Translation: AAH34520.1
CCDSiCCDS21656.1
RefSeqiNP_084078.3, NM_029802.4
UniGeneiMm.41637

Genome annotation databases

EnsembliENSMUST00000084782; ENSMUSP00000081840; ENSMUSG00000030881
ENSMUST00000131446; ENSMUSP00000120387; ENSMUSG00000030881
GeneIDi76932
KEGGimmu:76932
UCSCiuc009iyr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009100 mRNA Translation: BAB26070.1
AK154772 mRNA Translation: BAE32820.1
BC013794 mRNA Translation: AAH13794.1
BC022942 mRNA Translation: AAH22942.1
BC034520 mRNA Translation: AAH34520.1
CCDSiCCDS21656.1
RefSeqiNP_084078.3, NM_029802.4
UniGeneiMm.41637

3D structure databases

ProteinModelPortaliQ8K221
SMRiQ8K221
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218408, 1 interactor
IntActiQ8K221, 2 interactors
MINTiQ8K221
STRINGi10090.ENSMUSP00000081840

PTM databases

iPTMnetiQ8K221
PhosphoSitePlusiQ8K221

Proteomic databases

EPDiQ8K221
MaxQBiQ8K221
PaxDbiQ8K221
PeptideAtlasiQ8K221
PRIDEiQ8K221

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084782; ENSMUSP00000081840; ENSMUSG00000030881
ENSMUST00000131446; ENSMUSP00000120387; ENSMUSG00000030881
GeneIDi76932
KEGGimmu:76932
UCSCiuc009iyr.2 mouse

Organism-specific databases

CTDi23647
MGIiMGI:1924182 Arfip2

Phylogenomic databases

eggNOGiKOG3876 Eukaryota
ENOG410YJUM LUCA
GeneTreeiENSGT00500000044828
HOGENOMiHOG000236308
HOVERGENiHBG050564
InParanoidiQ8K221
KOiK20314
OMAiHRDKYER
OrthoDBiEOG091G0H30
PhylomeDBiQ8K221
TreeFamiTF314945

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiArfip2 mouse
PROiPR:Q8K221
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030881 Expressed in 280 organ(s), highest expression level in pancreas
CleanExiMM_ARFIP2
ExpressionAtlasiQ8K221 baseline and differential
GenevisibleiQ8K221 MM

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR010504 AH_dom
IPR030798 Arfaptin_fam
PANTHERiPTHR12141 PTHR12141, 1 hit
PfamiView protein in Pfam
PF06456 Arfaptin, 1 hit
SMARTiView protein in SMART
SM01015 Arfaptin, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS50870 AH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARFP2_MOUSE
AccessioniPrimary (citable) accession number: Q8K221
Secondary accession number(s): Q3U3G6, Q9D7M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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