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Protein

Phosphofurin acidic cluster sorting protein 1

Gene

Pacs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphofurin acidic cluster sorting protein 1
Short name:
PACS-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pacs1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277113 Pacs1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000581722 – 961Phosphofurin acidic cluster sorting protein 1Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei28PhosphoserineCombined sources1
Modified residuei44PhosphothreonineCombined sources1
Modified residuei249PhosphotyrosineCombined sources1
Modified residuei377PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei428PhosphoserineCombined sources1
Modified residuei493PhosphoserineBy similarity1
Modified residuei502PhosphothreonineBy similarity1
Modified residuei517PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei527PhosphoserineBy similarity1
Modified residuei529PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K212

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K212

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K212

PeptideAtlas

More...
PeptideAtlasi
Q8K212

PRoteomics IDEntifications database

More...
PRIDEi
Q8K212

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K212

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K212

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024855 Expressed in 260 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
MM_PACS1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K212 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with AP-1 and AP-3 but not with AP-2 complexes (By similarity). Interacts with FURIN (PubMed:9695949). Forms a ternary complex with FURIN and AP-1 (By similarity). Interacts with PKD2 (via acidic region) (PubMed:15692563).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
223732, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8K212, 2 interactors

Molecular INTeraction database

More...
MINTi
Q8K212

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025786

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8K212

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili351 – 375Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 82Ser-richAdd BLAST30
Compositional biasi60 – 63Poly-Ala4
Compositional biasi110 – 113Poly-Ser4
Compositional biasi277 – 281Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PACS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3709 Eukaryota
ENOG410XQNV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047329

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K212

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQWQTHI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02CK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K212

TreeFam database of animal gene trees

More...
TreeFami
TF314240

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019381 Phosphofurin_acidic_CS-1

The PANTHER Classification System

More...
PANTHERi
PTHR13280 PTHR13280, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10254 Pacs-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K212-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERGGAGGG PGGSGGGSSQ RGSGVAQSPQ QQPQQQPPQP QQPTPPKLAQ
60 70 80 90 100
ATSSSSSTSA AAASSSSSST STSMAVAVAS GSAPPGGPGP GRTPAPVQMN
110 120 130 140 150
LYATWEVDRS SSSCVPRLFS LTLKKLVMLK EMDKDLNSVV IAVKLQGSKR
160 170 180 190 200
ILRSNEIILP ASGLVETELQ LTFSLQYPHF LKRDANKLQI MLQRRKRYKN
210 220 230 240 250
RTILGYKTLA VGLINMAEVM QHPNEGALVL GLHSNVKDVS VPVAEIKIYS
260 270 280 290 300
LSSQPIDHEG IKSKLSDRSP DIDNYSEEEE ESFSSEQEGS DDPLHGQDLF
310 320 330 340 350
YEDEDLRKVK KTRRKLTSTS AITRQPNIKQ KFVALLKRFK VSDEVGFGLE
360 370 380 390 400
HVSREQIREV EEDLDELYDS LEMYNPSDSG PEMEETESIL STPKPKLKPF
410 420 430 440 450
FEGMSQSSSQ TEIGSLNSKG SLGKDTTSPM ELAALEKVKS TWIKNQDDSL
460 470 480 490 500
TETDTLEITD QDMFGDVSTS LVVPEKVKTP MKSSKADLQG SASPSKVEGT
510 520 530 540 550
HTPRQKRSTP LKERQLSKPL SERTNSSDSE RSPDLGHSTQ IPRKVVYDQL
560 570 580 590 600
NQILVSDAAL PENVILVNTT DWQGQYVAEL LQDQRKPVVC TCSTVEVQAV
610 620 630 640 650
LSALLTRIQR YCNCNSSMPR PVKVAAVGSQ SYLSSILRFF VKSLASKTPD
660 670 680 690 700
WLGYMRFLII PLGSHPVAKY LGSVDSRYSS TFLDSAWRDL FSRSEPPVSE
710 720 730 740 750
PLDVVGRVMQ YVNGATTTHQ LPVAEAMLTC RHKFPDEDSY QKFIPFIGVV
760 770 780 790 800
KVGLVEDSPS TAGDGDDSPV VSLTVPSTSP PSSSGLSRDA TATPPSSPSM
810 820 830 840 850
SSALAIVGSP NSPYGDVIGL QVDYWLGHPG ERRREGDKRD ASSKNTLKSV
860 870 880 890 900
FRSVQVSRLP HAGEAQLSGT MAMTVVTKEK NKKVPTIFLS KKPREKEVDS
910 920 930 940 950
KSQVIEGISR LICSAKQQQT MLRVSIDGVE WSDIKFFQLA AQWPTHVKHF
960
PVGLFSGSKT T
Length:961
Mass (Da):104,829
Last modified:September 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA57F3D86800D9B83
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti816D → E in AAH34670 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC062886 mRNA Translation: AAH62886.1
BC034670 mRNA Translation: AAH34670.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29453.1

NCBI Reference Sequences

More...
RefSeqi
NP_694769.2, NM_153129.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.234923

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107975

UCSC genome browser

More...
UCSCi
uc008gci.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062886 mRNA Translation: AAH62886.1
BC034670 mRNA Translation: AAH34670.1
CCDSiCCDS29453.1
RefSeqiNP_694769.2, NM_153129.2
UniGeneiMm.234923

3D structure databases

ProteinModelPortaliQ8K212
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223732, 4 interactors
IntActiQ8K212, 2 interactors
MINTiQ8K212
STRINGi10090.ENSMUSP00000025786

PTM databases

iPTMnetiQ8K212
PhosphoSitePlusiQ8K212

Proteomic databases

EPDiQ8K212
MaxQBiQ8K212
PaxDbiQ8K212
PeptideAtlasiQ8K212
PRIDEiQ8K212

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025786; ENSMUSP00000025786; ENSMUSG00000024855
GeneIDi107975
KEGGimmu:107975
UCSCiuc008gci.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55690
MGIiMGI:1277113 Pacs1

Phylogenomic databases

eggNOGiKOG3709 Eukaryota
ENOG410XQNV LUCA
GeneTreeiENSGT00940000156203
HOGENOMiHOG000047329
HOVERGENiHBG053488
InParanoidiQ8K212
OMAiSQWQTHI
OrthoDBiEOG091G02CK
PhylomeDBiQ8K212
TreeFamiTF314240

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pacs1 mouse

Protein Ontology

More...
PROi
PR:Q8K212

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024855 Expressed in 260 organ(s), highest expression level in testis
CleanExiMM_PACS1
GenevisibleiQ8K212 MM

Family and domain databases

InterProiView protein in InterPro
IPR019381 Phosphofurin_acidic_CS-1
PANTHERiPTHR13280 PTHR13280, 1 hit
PfamiView protein in Pfam
PF10254 Pacs-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPACS1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K212
Secondary accession number(s): Q6P5H8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: September 13, 2004
Last modified: December 5, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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