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UniProtKB - Q8K205 (Q8K205_MOUSE)

Entry version 133 (19 Jan 2022)
Sequence version 1 (01 Oct 2002)
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Protein
Submitted name:

Processing of 1, ribonuclease P/MRP family, (S. cerevisiae)

Gene

Pop1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Processing of 1, ribonuclease P/MRP family, (S. cerevisiae)Imported
Submitted name:
Processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pop1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914974, Pop1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022325

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		339049

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022325, Expressed in embryonic stem cell and 200 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000052654

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini107 – 182POP1InterPro annotationAdd BLAST76
Domaini172 – 257POP1InterPro annotationAdd BLAST86
Domaini647 – 738POPLDInterPro annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 57DisorderedSequence analysisAdd BLAST57
Regioni374 – 413DisorderedSequence analysisAdd BLAST40
Regioni934 – 957DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 176Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 57Polar residuesSequence analysisAdd BLAST16
Compositional biasi376 – 404Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi934 – 948Basic and acidic residuesSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3322, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017478

Identification of Orthologs from Complete Genome Data

More...OMAi		YYCCIEL

Database of Orthologous Groups

More...OrthoDBi		543991at2759

TreeFam database of animal gene trees

More...TreeFami		TF314236

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039182, Pop1
IPR009723, Pop1_N
IPR012590, POPLD_dom

The PANTHER Classification System

More...PANTHERi		PTHR22731, PTHR22731, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06978, POP1, 2 hits
PF08170, POPLD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNAKERKHA KKMRNQPSNV TLSSGFMAER DGKHHFGKGK PSQSQKQELH 
        60         70         80         90        100
SGTSRQWQIK MSPHLLPESD VNEQSSSKTM FKKKGGWKAG PEGTSQEIPK 
       110        120        130        140        150
YITASTFAQA RAAEISAMLK AVTQKSSNSL VFQTLPRHMR RRAMSHNVKR 
       160        170        180        190        200
LPRRLQEMAK KEAEKAAHQK KEHSKNKCHK ARRCHINRTL EFNRRQQKNI 
       210        220        230        240        250
WLETHIWHAK RFHMVKKWGY CLGERPTAKS HRACYRAMTN LCLLQDLSYY 
       260        270        280        290        300
CCLELKGKEE ELLKALSQMC SIDAGLTFAA VHCLSGKRQG SLMLYRANKY 
       310        320        330        340        350
PREMLGPVTF IWKSRMTPED ASEDRQLWIW LHPTLKLAVL EEIKTTCHCS 
       360        370        380        390        400
EPVKSNICMP DPLLTPAPED IQAGLAGDKI SKKRKRRDDG ESVSRAKKTI 
       410        420        430        440        450
GDGTRDACQP RSWRSPTTGI IVSDLTMEMN RFRLIGPLSH CILTSALRAA 
       460        470        480        490        500
PVHTGEEDAE ETPHHWWTDT CRSSDGRSLH QRQEAVFELL GGISSPAEIP 
       510        520        530        540        550
AGTILGLTVR DPRVNLPPQR SRALPDPERY QVSEFTCEEG MCTGSWSCAH 
       560        570        580        590        600
WKPLSDHTDD PANERVKQLL LEGVPVACAH SFIWDQDICR SVTENKLLDQ 
       610        620        630        640        650
DLNRMRSELL VPGSQLDLGA RESKIPILLI QQPGKVTGED RLGWGSGWDV 
       660        670        680        690        700
LIPKGWGMAF WIPFIYRGAR VGGLKEATVH SQYRRSPNIP GDFPDCRAGV 
       710        720        730        740        750
LFAEDQAKDL LEKYRRRPPA KRPNYVKLGT LAPFCCPWEQ LTRDWESRVH 
       760        770        780        790        800
AQEAAIIASM PGAQETDPRR LGVPCVPKEI CQLSNEAGIA ENQPRKPEVT 
       810        820        830        840        850
GCQAQEGTKV AMEWNASEAH MATTGSQLCV VRSRKLLKQL SSWCGPSSEI 
       860        870        880        890        900
RRAPCRAQQE LTSNVCLSIL NDFPRALVWV SLSLLRKGSP EPHTMICVPS 
       910        920        930        940        950
KEDLHRLSQD QCYHGPWESR HSDPFKSLIL KEKEKKKKEK RQDGEHRASE 
       960        970        980        990       1000
GQAAGPPIAG QEALTQGLWS GPLPGLTSHC SRLLLGFVTQ GDFSMAAGCG 
      1010       1020       1030       1040 
EALGFVSMTG LLEMLSSQSA AMRGLVLLRP PTSLQYRFAR ITIEV
Length:1,045
Mass (Da):117,367
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0BF956CF7DEA2004
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D4G5Q9D4G5_MOUSE
Processing of precursor 1, ribonucl...
Pop1
1,015Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC034742 mRNA Translation: AAH34742.1

NCBI Reference Sequences

More...RefSeqi		NP_690854.1, NM_152894.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000052290; ENSMUSP00000052654; ENSMUSG00000022325

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67724

UCSC genome browser

More...UCSCi		uc007vlu.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034742 mRNA Translation: AAH34742.1
RefSeqiNP_690854.1, NM_152894.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052654

Proteomic databases

ProteomicsDBi339049

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26061, 91 antibodies from 17 providers

Genome annotation databases

EnsembliENSMUST00000052290; ENSMUSP00000052654; ENSMUSG00000022325
GeneIDi67724
UCSCiuc007vlu.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10940
MGIiMGI:1914974, Pop1
VEuPathDBiHostDB:ENSMUSG00000022325

Phylogenomic databases

eggNOGiKOG3322, Eukaryota
GeneTreeiENSGT00390000017478
OMAiYYCCIEL
OrthoDBi543991at2759
TreeFamiTF314236

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67724, 22 hits in 65 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022325, Expressed in embryonic stem cell and 200 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR039182, Pop1
IPR009723, Pop1_N
IPR012590, POPLD_dom
PANTHERiPTHR22731, PTHR22731, 1 hit
PfamiView protein in Pfam
PF06978, POP1, 2 hits
PF08170, POPLD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8K205_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K205
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 19, 2022
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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