UniProtKB - Q8K203 (NEIL3_MOUSE)

BLAST

>sp|Q8K203|NEIL3_MOUSE Endonuclease 8-like 3 OS=Mus musculus OX=10090 GN=Neil3 PE=1 SV=1
MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALQSLLGPAMSPAASLADVATSAAPMNAKD
SGWKLLRLFNGYVYSGVETLGKELFMYFGPRALRIHFGMKGSILINPREGENRAGASPAL
AVQLTRDLICFYDSSVELRNSVESQQRVRVMEELDICSPKFSFSRAESEVKKQGDRMLCD
VLLDQRVLPGVGNIIKNEALFDSGLHPAVKVCQLSDKQACHLVKMTRDFSILFYRCCKAG
SAISKHCKVYKRPNCDQCHSKITVCRFGENSRMTYFCPHCQKENPQCVQVCQLPTRNTEI
SWTPRGEDCFTDSVARKSEEQWSCVVCTLINRPSAKACDACLTTRPLDSVLKNRENSIAF
NNLVKYPCNNFENTHTEVKINRKTAFGNTTLVLTDLSNKSSALARKKRANHTIDGESQMF
LPTDIGFSDSQHPSKEGINYITQPSNKVNISPTVCAQSKLFSSAHKKFKPAHTSATELKS
YNSGLSNSELQTNRTRGHHSKSDGSPLCKMHHRRCVLRVVRKDGENKGRQFYACSLPRGA
QCGFFEWADLSFPFCRHGKRSIMKTVLKIGPNNGKNFFVCPLEKKKQCNFFQWAENGPGM
EIVPGC

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History
Entry version 126 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Endonuclease 8-like 3

Gene

Neil3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.6 Publications

Caution

Was originally thought to be inactive as a glycosylase, but recent reports (PMID:22569481, PMID:20185759) demonstrate that cleavage of the initiator methionine is essential for catalytic activity.Curated

Catalytic activityⁱ

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	2	Schiff-base intermediate with DNA; via amino nitrogen1 Publication	1
Siteⁱ	2	Important for monofunctional glycosylase activityBy similarity	1
Siteⁱ	82	Required for glycosylase activityBy similarity	1
Binding siteⁱ	193	DNABy similarity	1
Binding siteⁱ	272	DNABy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	248 – 282	FPG-typePROSITE-ProRule annotationAdd BLAST		35
Zinc fingerⁱ	318 – 347	RanBP2-typePROSITE-ProRule annotationAdd BLAST		30

GO - Molecular functionⁱ

bubble DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB-EC
damaged DNA binding Source: InterPro
DNA-(apurinic or apyrimidinic site) endonuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
DNA N-glycosylase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
double-stranded DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
single-stranded DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

base-excision repair
Source: UniProtKB
Inferred from direct assayⁱ
- 20185759
nucleotide-excision repair Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Glycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological process	DNA damage, DNA repair
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endonuclease 8-like 3 (EC:3.2.2.-, EC:4.2.99.18) Alternative name(s): DNA glycosylase FPG2 DNA glycosylase/AP lyase Neil3 Endonuclease VIII-like 3 Nei-like protein 3
Gene namesⁱ	Name:Neil3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2384588 Neil3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Perinatal mice show reduced regeneration of neural tissue following ischemic brain damage (stroke), associated with fewer activated microglia and impaired neural stem cell proliferation. Aged mice show deficits in learning and memory, decreased anxiety-like behavior, and changes in hippocampal synapse composition. Otherwise viable and fertile.4 Publications

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCurated
ChainⁱPRO_0000170911	2 – 606	Endonuclease 8-like 3Add BLAST		605

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	451	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8K203
PaxDbⁱ	Q8K203
PeptideAtlas More...PeptideAtlasⁱ	Q8K203
PRIDEⁱ	Q8K203

PTM databases

iPTMnetⁱ	Q8K203
PhosphoSitePlusⁱ	Q8K203

Expressionⁱ

Tissue specificityⁱ

Expressed in testis, thymus, spleen and bone marrow. In young mice, expressed at higher levels in thymocytes than splenocytes. At E12, abundant in the subventricular zone (SVZ) of the lateral ventricles. At E17.5 and P0, expression is limited to distinct cells in the cortical SVZ, in cells of the secondary matrix, the dentate gyrus migratory route and the dentate gyrus.4 Publications

Developmental stageⁱ

Highly expressed in the developing brain at E12-E13 when neurogenesis starts. Expression decreases during later development and is undetectable in adult brain.2 Publications

Inductionⁱ

By mitogen stimulation in splenocytes, and by hypoxic-ischemic injury in the striatum and hippocampus.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000039396 Expressed in 165 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_NEIL3
ExpressionAtlasⁱ	Q8K203 baseline and differential
Genevisibleⁱ	Q8K203 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000041909

STRINGⁱ

10090.ENSMUSP00000041909

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 17	Combined sources	14
Beta strandⁱ	23 – 28	Combined sources	6
Helixⁱ	30 – 34	Combined sources	5
Helixⁱ	64 – 68	Combined sources	5
Turnⁱ	69 – 71	Combined sources	3
Beta strandⁱ	73 – 80	Combined sources	8
Beta strandⁱ	83 – 88	Combined sources	6
Beta strandⁱ	91 – 106	Combined sources	16
Beta strandⁱ	119 – 126	Combined sources	8
Beta strandⁱ	128 – 140	Combined sources	13
Helixⁱ	141 – 151	Combined sources	11
Helixⁱ	152 – 154	Combined sources	3
Helixⁱ	163 – 171	Combined sources	9
Beta strandⁱ	175 – 177	Combined sources	3
Helixⁱ	178 – 183	Combined sources	6
Turnⁱ	185 – 187	Combined sources	3
Helixⁱ	193 – 203	Combined sources	11
Helixⁱ	211 – 213	Combined sources	3
Helixⁱ	216 – 239	Combined sources	24
Helixⁱ	243 – 246	Combined sources	4
Turnⁱ	256 – 258	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Beta strandⁱ	274 – 276	Combined sources	3
Turnⁱ	278 – 280	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8K203
SMRⁱ	Q8K203
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domainⁱ

The N-terminal region (2-282) contains the glycosylase and lyase activities.

Sequence similaritiesⁱ

Belongs to the FPG family.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	248 – 282	FPG-typePROSITE-ProRule annotationAdd BLAST		35
Zinc fingerⁱ	318 – 347	RanBP2-typePROSITE-ProRule annotationAdd BLAST		30

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IETI Eukaryota ENOG410ZE81 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110955
HOGENOMⁱ	HOG000113754
HOVERGENⁱ	HBG052594
InParanoidⁱ	Q8K203
KEGG Orthology (KO) More...KOⁱ	K10569
OMAⁱ	ELDVCSP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G038I
PhylomeDBⁱ	Q8K203
TreeFamⁱ	TF331502

Family and domain databases

Gene3Dⁱ	3.20.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR015886 DNA_glyclase/AP_lyase_DNA-bd IPR015887 DNA_glyclase_Znf_dom_DNA_BS IPR012319 FPG_cat IPR035937 MutM-like_N-ter IPR010979 Ribosomal_S13-like_H2TH IPR000214 Znf_DNA_glyclase/AP_lyase IPR010666 Znf_GRF IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06831 H2TH, 1 hit PF06839 zf-GRF, 2 hits PF00641 zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM01232 H2TH, 1 hit SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF46946 SSF46946, 1 hit SSF81624 SSF81624, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS51068 FPG_CAT, 1 hit PS01242 ZF_FPG_1, 1 hit PS51066 ZF_FPG_2, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q8K203-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEGPGCTLN GEKIRARVLP GQAVTGVRGT ALQSLLGPAM SPAASLADVA 
        60         70         80         90        100
TSAAPMNAKD SGWKLLRLFN GYVYSGVETL GKELFMYFGP RALRIHFGMK 
       110        120        130        140        150
GSILINPREG ENRAGASPAL AVQLTRDLIC FYDSSVELRN SVESQQRVRV 
       160        170        180        190        200
MEELDICSPK FSFSRAESEV KKQGDRMLCD VLLDQRVLPG VGNIIKNEAL 
       210        220        230        240        250
FDSGLHPAVK VCQLSDKQAC HLVKMTRDFS ILFYRCCKAG SAISKHCKVY 
       260        270        280        290        300
KRPNCDQCHS KITVCRFGEN SRMTYFCPHC QKENPQCVQV CQLPTRNTEI 
       310        320        330        340        350
SWTPRGEDCF TDSVARKSEE QWSCVVCTLI NRPSAKACDA CLTTRPLDSV 
       360        370        380        390        400
LKNRENSIAF NNLVKYPCNN FENTHTEVKI NRKTAFGNTT LVLTDLSNKS 
       410        420        430        440        450
SALARKKRAN HTIDGESQMF LPTDIGFSDS QHPSKEGINY ITQPSNKVNI 
       460        470        480        490        500
SPTVCAQSKL FSSAHKKFKP AHTSATELKS YNSGLSNSEL QTNRTRGHHS 
       510        520        530        540        550
KSDGSPLCKM HHRRCVLRVV RKDGENKGRQ FYACSLPRGA QCGFFEWADL 
       560        570        580        590        600
SFPFCRHGKR SIMKTVLKIG PNNGKNFFVC PLEKKKQCNF FQWAENGPGM 

EIVPGC

Length:606

Mass (Da):67,416

Last modified:October 1, 2002 - v1

Checksum:ⁱ941C38FA8538BAA8

Isoform 2 (identifier: Q8K203-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
212-606: Missing.

« Hide

        10         20         30         40         50
MVEGPGCTLN GEKIRARVLP GQAVTGVRGT ALQSLLGPAM SPAASLADVA 
        60         70         80         90        100
TSAAPMNAKD SGWKLLRLFN GYVYSGVETL GKELFMYFGP RALRIHFGMK 
       110        120        130        140        150
GSILINPREG ENRAGASPAL AVQLTRDLIC FYDSSVELRN SVESQQRVRV 
       160        170        180        190        200
MEELDICSPK FSFSRAESEV KKQGDRMLCD VLLDQRVLPG VGNIIKNEAL 
       210 
FDSGLHPAVK V

Note: May be due to an intron retention.

Show »

Length:211

Mass (Da):22,840

Checksum:ⁱE7643F8B173F69CE

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3Z1T7	D3Z1T7_MOUSE		Endonuclease 8-like 3 Endonuclease 8-like 3	Neil3	49	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	46	L → P in strain: Czech II. 1 Publication	1
Natural variantⁱ	90	P → H in strain: Czech II. 1 Publication	1
Natural variantⁱ	114	A → G in strain: Czech II. 1 Publication	1
Natural variantⁱ	150	V → E in strain: Czech II. 1 Publication	1
Natural variantⁱ	220	C → R in strain: Czech II. 1 Publication	1
Natural variantⁱ	256	D → G in strain: Czech II. 1 Publication	1
Natural variantⁱ	287	C → R in strain: Czech II. 1 Publication	1
Natural variantⁱ	325	V → A in strain: Czech II. 1 Publication	1
Natural variantⁱ	556	R → K in strain: Czech II. 1 Publication	1
Natural variantⁱ	585	K → E in strain: Czech II. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012210	212 – 606	Missing in isoform 2. 1 PublicationAdd BLAST		395

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072931 mRNA Translation: BAC22661.1 AK031027 mRNA Translation: BAC27219.1 BC024921 mRNA Translation: AAH24921.1 BC034753 mRNA Translation: AAH34753.1 AB202125 Genomic DNA Translation: BAE16548.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22305.1 [Q8K203-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_666320.1, NM_146208.2 [Q8K203-1]
UniGeneⁱ	Mm.281749

Genome annotation databases

Ensemblⁱ	ENSMUST00000047768; ENSMUSP00000041909; ENSMUSG00000039396 [Q8K203-1]
GeneIDⁱ	234258
KEGGⁱ	mmu:234258
UCSC genome browser More...UCSCⁱ	uc009lsa.2 mouse [Q8K203-1] uc009lsb.2 mouse [Q8K203-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K203	Isoform 2 of Endonuclease 8-like 3		MOUSE		211	UniRef100_Q8K203
Endonuclease 8-like 3 (Fragment)		MOUSE		49

Protein	Similar proteins		Species	Score	Length	Source
Q8K203	Isoform 2 of Endonuclease 8-like 3		MOUSE		211	UniRef90_Q8K203
UPI000A304361		MUSPA		606
UPI000A319014		MUSCR		606
Endonuclease 8-like 3 (Fragment)		MOUSE		49

Protein	Similar proteins		Species	Score	Length	Source
Q8K203	Endonuclease 8-like 3		HUMAN		605	UniRef50_Q8TAT5
Endonuclease 8-like 3		BOVIN		606
NEIL3 isoform 1		PONAB		606
Uncharacterized protein		NOMLE		606
Nei like DNA glycosylase 3		GORGO		606
+364

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072931 mRNA Translation: BAC22661.1 AK031027 mRNA Translation: BAC27219.1 BC024921 mRNA Translation: AAH24921.1 BC034753 mRNA Translation: AAH34753.1 AB202125 Genomic DNA Translation: BAE16548.1
CCDSⁱ	CCDS22305.1 [Q8K203-1]
RefSeqⁱ	NP_666320.1, NM_146208.2 [Q8K203-1]
UniGeneⁱ	Mm.281749

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3W0F	X-ray	2.00	A	2-282	[»]
ProteinModelPortalⁱ	Q8K203
SMRⁱ	Q8K203
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000041909

STRINGⁱ

10090.ENSMUSP00000041909

PTM databases

iPTMnetⁱ	Q8K203
PhosphoSitePlusⁱ	Q8K203

Proteomic databases

EPDⁱ	Q8K203
PaxDbⁱ	Q8K203
PeptideAtlasⁱ	Q8K203
PRIDEⁱ	Q8K203

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047768; ENSMUSP00000041909; ENSMUSG00000039396 [Q8K203-1]
GeneIDⁱ	234258
KEGGⁱ	mmu:234258
UCSCⁱ	uc009lsa.2 mouse [Q8K203-1] uc009lsb.2 mouse [Q8K203-2]

Organism-specific databases

CTDⁱ	55247
MGIⁱ	MGI:2384588 Neil3

Phylogenomic databases

eggNOGⁱ	ENOG410IETI Eukaryota ENOG410ZE81 LUCA
GeneTreeⁱ	ENSGT00730000110955
HOGENOMⁱ	HOG000113754
HOVERGENⁱ	HBG052594
InParanoidⁱ	Q8K203
KOⁱ	K10569
OMAⁱ	ELDVCSP
OrthoDBⁱ	EOG091G038I
PhylomeDBⁱ	Q8K203
TreeFamⁱ	TF331502

Miscellaneous databases

ChiTaRSⁱ	Neil3 mouse
Protein Ontology More...PROⁱ	PR:Q8K203
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039396 Expressed in 165 organ(s), highest expression level in bone marrow
CleanExⁱ	MM_NEIL3
ExpressionAtlasⁱ	Q8K203 baseline and differential
Genevisibleⁱ	Q8K203 MM

Family and domain databases

Gene3Dⁱ	3.20.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR015886 DNA_glyclase/AP_lyase_DNA-bd IPR015887 DNA_glyclase_Znf_dom_DNA_BS IPR012319 FPG_cat IPR035937 MutM-like_N-ter IPR010979 Ribosomal_S13-like_H2TH IPR000214 Znf_DNA_glyclase/AP_lyase IPR010666 Znf_GRF IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
Pfamⁱ	View protein in Pfam PF06831 H2TH, 1 hit PF06839 zf-GRF, 2 hits PF00641 zf-RanBP, 1 hit
SMARTⁱ	View protein in SMART SM01232 H2TH, 1 hit SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF46946 SSF46946, 1 hit SSF81624 SSF81624, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS51068 FPG_CAT, 1 hit PS01242 ZF_FPG_1, 1 hit PS51066 ZF_FPG_2, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEIL3_MOUSE
Accessionⁱ	Q8K203Primary (citable) accession number: Q8K203 Secondary accession number(s): Q4ADY6, Q8CD85, Q8R3P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q8K203 (NEIL3_MOUSE)

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Endonuclease 8-like 3

Neil3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ