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UniProtKB - Q8K1X4 (NCKPL_MOUSE)

Entry version 138 (23 Feb 2022)
Sequence version 1 (01 Oct 2002)
Previous versions | rss
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Protein

Nck-associated protein 1-like

Gene

Nckap1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:19015308, PubMed:23424621).

Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization (PubMed:23424621).

Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (PubMed:19015308).

Within the WAVE2 complex, enables the cortical actin network to restrain excessive degranulation and granule release by T-cells. Required for efficient T-lymphocyte and neutrophil migration (By similarity).

Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE independent to regulate myosin and actin polymerization during neutrophil chemotaxis (By similarity).

In T-cells, required for proper mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, cell proliferation and cytokine secretion, including that of IL2 and TNF (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695, Neutrophil degranulation
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013423, RAC3 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 1-likeCurated
Alternative name(s):
Hematopoietic protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nckap1lImported
Synonyms:Hem1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1926063, Nckap1l

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022488

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants exhibit lymphopenia, neutrophilia and anemia. T cell development is disrupted at the CD4-CD8- to CD4+CD8+ cell stages and T cell activation and adhesion are impaired. Neutrophils fail to migrate in response to chemotactic agents and are deficient in their ability to phagocytose bacteria. They show enhanced Th17 cells production (PubMed:19015308). The anemia is microcytic, hypochromic and characterized by abnormally shaped erythrocytes with aberrant F-actin foci and decreased lifespan (PubMed:23424621).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004392101 – 1134Nck-associated protein 1-likeAdd BLAST1134

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8K1X4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8K1X4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8K1X4

PeptideAtlas

More...PeptideAtlasi		Q8K1X4

PRoteomics IDEntifications database

More...PRIDEi		Q8K1X4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		252925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8K1X4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8K1X4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in developing and mature hematopoietic cells. Also detected in urogenital tissues, including testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022488, Expressed in granulocyte and 183 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8K1X4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

In hematopoietic cells, component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1L/HEM1 and WASF2/WAVE2.

Interacts with ARHGAP4, PIK3C3/VPS34 and PPP1R12A/MYPT1.

Interacts with mammalian target of rapamycin complex 2 (mTORC2) components, including MTOR and RICTOR.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8K1X4, 1 interactor

Molecular INTeraction database

More...MINTi		Q8K1X4

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000035400

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8K1X4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8K1X4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni638 – 671DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi648 – 671Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1917, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004450_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8K1X4

Identification of Orthologs from Complete Genome Data

More...OMAi		TYNCAHE

Database of Orthologous Groups

More...OrthoDBi		138196at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8K1X4

TreeFam database of animal gene trees

More...TreeFami		TF313683

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019137, Nck-associated_protein-1

The PANTHER Classification System

More...PANTHERi		PTHR12093, PTHR12093, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09735, Nckap1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K1X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTSAYQLK LAEKLTILND RGQGVLIRMY NIKKTCSDSK SKPPFLLEKS 
        60         70         80         90        100
MESCLKYINK KFPNIDVRNS TQHLGPVHRE KAEIIRFLTN YYQSFVDVME 
       110        120        130        140        150
FRDHVYELLN TIDACQCHFD INLNFDFTRS YLDLIVTYTS VILLLSRIED 
       160        170        180        190        200
RRILIGMYNC AHEMLHGHSD PSFARLGQMV LEYDHPLKKL TEEFGPHTKA 
       210        220        230        240        250
VSGALLSLHF LFVRRNQGAE QWRSAQLLSL ISSPPAMINP ANSDTMACEY 
       260        270        280        290        300
LSVEVMERWI IIGFLLCHGC LNSNSQCQKL WKLCLEGSLY ITLIREDVLQ 
       310        320        330        340        350
VHKVTEDLFS SLKGYSKRVA DIKESKEHAI TNSGQFHCQR RQFLRTAVKE 
       360        370        380        390        400
LETVLNDEPG LLGPKALFAF MALSFIRDEV TWLVRHTENV TKTKTPEDYA 
       410        420        430        440        450
DSSIAELLFL LEEIRALVRR HIKVIQQYHL QYLARFDVLV LSDIIQNLSV 
       460        470        480        490        500
CPEEESVIMS SFVSILSSLN LKQVDNEEKF DFSGLRLDWF RLQAYTSVSK 
       510        520        530        540        550
APLHLHENPD LAKVMNLIIF HSQMLDSVEK MLVETSDLST FCFHLRTFEK 
       560        570        580        590        600
MFATTLEEPT MLRYTIAFPL ICAHFVHCVH EMCPEEYPHL KNHGLHHCNS 
       610        620        630        640        650
FLEDLAKQTS NCVLEICAEQ RNLNEQLLPK HCATTISKAK NKKSMKQRQA 
       660        670        680        690        700
PRKGEPERDK PGAESHRKNR SLVTNMDKLH LNLTELALAM NHVHSFSVFE 
       710        720        730        740        750
HTIFPSEYLS SHLEARLNRA IVTLAGYNAT TQEILRPSEL LAGVKAYISF 
       760        770        780        790        800
IQSLAQFLGA DASRIVRNAL LQQTQPLDSS GEQTVTTLYT NWYLESLLRQ 
       810        820        830        840        850
ASSGAIVLSP AMQAFISLPR DGEQNFSAEE FSDISEMRAL AEILGPYGMK 
       860        870        880        890        900
FLSENLMWHV TSQIVELKKL VVENMDILVQ IRSNFSKPEL MASLLPQLTG 
       910        920        930        940        950
AENVLKRMTI IGVILSFRAM AQEGLQEVFS AHCPFLMGPI ECLKEFVTPD 
       960        970        980        990       1000
TDIKVTLSVF ELACAAGVSC DIDPALVAAI ANLKADNSSP EEEYKVACLL 
      1010       1020       1030       1040       1050
LIFLAVSLPL LATDPSSFFS IEKDGYNNNI HCLTKAIIQV SAALFTLYNK 
      1060       1070       1080       1090       1100
NIETHLKEFL VVASVSLLQL GQETDKLKTR NRESISLLMR LVVEESPFLT 
      1110       1120       1130 
LDMLESCFPY VLLRNAYREV SRAFYLNRLP ASSH
Length:1,134
Mass (Da):128,905
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5780D0AF3B00E767
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHC4A0A2R8VHC4_MOUSE
Nck-associated protein 1-like
Nckap1l
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK083390 mRNA Translation: BAC38898.1
AC131721 Genomic DNA No translation available.
BC037096 mRNA Translation: AAH37096.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37236.1

NCBI Reference Sequences

More...RefSeqi		NP_705725.1, NM_153505.4
XP_006520318.2, XM_006520255.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000047405; ENSMUSP00000035400; ENSMUSG00000022488

Database of genes from NCBI RefSeq genomes

More...GeneIDi		105855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:105855

UCSC genome browser

More...UCSCi		uc007xyf.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083390 mRNA Translation: BAC38898.1
AC131721 Genomic DNA No translation available.
BC037096 mRNA Translation: AAH37096.1
CCDSiCCDS37236.1
RefSeqiNP_705725.1, NM_153505.4
XP_006520318.2, XM_006520255.3

3D structure databases

SMRiQ8K1X4
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8K1X4, 1 interactor
MINTiQ8K1X4
STRINGi10090.ENSMUSP00000035400

PTM databases

iPTMnetiQ8K1X4
PhosphoSitePlusiQ8K1X4

Proteomic databases

EPDiQ8K1X4
MaxQBiQ8K1X4
PaxDbiQ8K1X4
PeptideAtlasiQ8K1X4
PRIDEiQ8K1X4
ProteomicsDBi252925

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		27500, 164 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		105855

Genome annotation databases

EnsembliENSMUST00000047405; ENSMUSP00000035400; ENSMUSG00000022488
GeneIDi105855
KEGGimmu:105855
UCSCiuc007xyf.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3071
MGIiMGI:1926063, Nckap1l
VEuPathDBiHostDB:ENSMUSG00000022488

Phylogenomic databases

eggNOGiKOG1917, Eukaryota
GeneTreeiENSGT00390000016619
HOGENOMiCLU_004450_0_0_1
InParanoidiQ8K1X4
OMAiTYNCAHE
OrthoDBi138196at2759
PhylomeDBiQ8K1X4
TreeFamiTF313683

Enzyme and pathway databases

ReactomeiR-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs
R-MMU-6798695, Neutrophil degranulation
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013423, RAC3 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		105855, 1 hit in 64 CRISPR screens

Protein Ontology

More...PROi		PR:Q8K1X4
RNActiQ8K1X4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022488, Expressed in granulocyte and 183 other tissues
ExpressionAtlasiQ8K1X4, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR019137, Nck-associated_protein-1
PANTHERiPTHR12093, PTHR12093, 1 hit
PfamiView protein in Pfam
PF09735, Nckap1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCKPL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K1X4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2017
Last sequence update: October 1, 2002
Last modified: February 23, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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