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Protein

Kremen protein 2

Gene

Kremen2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822).2 Publications

GO - Biological processi

  • cell communication Source: GO_Central
  • limb development Source: UniProtKB
  • negative regulation of ossification Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Names & Taxonomyi

Protein namesi
Recommended name:
Kremen protein 2
Alternative name(s):
Dickkopf receptor 2
Kringle domain-containing transmembrane protein 2
Kringle-containing protein marking the eye and the nose
Gene namesi
Name:Kremen2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1920266 Kremen2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 363ExtracellularSequence analysisAdd BLAST339
Transmembranei364 – 386HelicalSequence analysisAdd BLAST23
Topological domaini387 – 461CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Animals with a double knockout of KREM1 and KREM2 exhibit enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ectodermal ridges. They also exhibit increased bone volume and bone formation rates. Triple knockout mice KREM1/KREM2/DKK1 exhibit enhanced growth of ectopic digits.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002156925 – 461Kremen protein 2Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 118By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 99By similarity
Disulfide bondi88 ↔ 113By similarity
Disulfide bondi218 ↔ 244By similarity
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K1S7
PRIDEiQ8K1S7

PTM databases

PhosphoSitePlusiQ8K1S7

Expressioni

Developmental stagei

Expressed in the developing brain and developing limb buds.1 Publication

Gene expression databases

BgeeiENSMUSG00000040680 Expressed in 26 organ(s), highest expression level in embryo
CleanExiMM_KREMEN2

Interactioni

Subunit structurei

Interacts with ERLEC1 (PubMed:16531414). Forms a ternary complex with DKK1 and LRP6 (PubMed:12050670).2 Publications

Protein-protein interaction databases

BioGridi215713, 1 interactor
CORUMiQ8K1S7
STRINGi10090.ENSMUSP00000046369

Structurei

3D structure databases

ProteinModelPortaliQ8K1S7
SMRiQ8K1S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 118KringlePROSITE-ProRule annotationAdd BLAST85
Domaini120 – 214WSCPROSITE-ProRule annotationCuratedAdd BLAST95
Domaini218 – 325CUBPROSITE-ProRule annotationCuratedAdd BLAST108

Domaini

Binding to ERLEC1 is mediated by the oligosaccharides linked to the kringle domain.1 Publication

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4157 Eukaryota
ENOG4111FP9 LUCA
GeneTreeiENSGT00730000110973
HOGENOMiHOG000070150
HOVERGENiHBG052291
InParanoidiQ8K1S7
OMAiGRSWAVW
OrthoDBiEOG091G053O
PhylomeDBiQ8K1S7
TreeFamiTF331319

Family and domain databases

CDDicd00041 CUB, 1 hit
cd00108 KR, 1 hit
Gene3Di2.40.20.10, 1 hit
2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR017076 Kremen
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR035914 Sperma_CUB_dom_sf
IPR002889 WSC_carb-bd
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00051 Kringle, 1 hit
PF01822 WSC, 1 hit
PIRSFiPIRSF036961 Kremen, 1 hit
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00130 KR, 1 hit
SM00321 WSC, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS51212 WSC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K1S7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPHLQGFL LLFPLLLRLH GASAGSLHSP GLSECFQVNG ADYRGHQNYT
60 70 80 90 100
GPRGAGRPCL FWDQTQQHSY SSASDPQGRW GLGAHNFCRN PDGDVQPWCY
110 120 130 140 150
VAETEEGIYW RYCDIPTCHM PGYLGCFVDS GAPPALSGPS GTSTKLTVQV
160 170 180 190 200
CLRFCRMKGY QLAGVEAGYA CFCGSESDLA RGRPAPATDC DQICFGHPGQ
210 220 230 240 250
LCGGDGRLGI YEVSVGSCQG NWSAPQGVIY SPDFPDEYGP DRNCSWVLGQ
260 270 280 290 300
LGAVLELTFR LFELADSRDR LELRDVSSGN LLRAFDGAHP PPPGPLRLRT
310 320 330 340 350
AALLLTFRSD ARGHAQGFAL TYRGLQDTVE GRASPEDSTE SLAGDPDGAN
360 370 380 390 400
ASCSPKPGAA QASIGARVFS TVTAFSVLLL LLLSLLRLLR RRSCLLAPGK
410 420 430 440 450
GSLAMGPSRG PGRSWAVWYR RPRGVALPCP PGDSQAEGPA AGYRPLSASS
460
QSSLRSLVSA L
Length:461
Mass (Da):49,170
Last modified:October 1, 2002 - v1
Checksum:i6D58C4A2858E09DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457192 mRNA Translation: CAD29805.1
BC120532 mRNA Translation: AAI20533.1
BC125438 mRNA Translation: AAI25439.1
CCDSiCCDS28462.1
RefSeqiNP_082692.1, NM_028416.2
XP_006525047.1, XM_006524984.3
UniGeneiMm.221319

Genome annotation databases

EnsembliENSMUST00000046525; ENSMUSP00000046369; ENSMUSG00000040680
GeneIDi73016
KEGGimmu:73016
UCSCiuc008atd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKREM2_MOUSE
AccessioniPrimary (citable) accession number: Q8K1S7
Secondary accession number(s): Q0VBR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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