UniProtKB - Q8K1S5 (KLF11_MOUSE)

BLAST

>sp|Q8K1S5|KLF11_MOUSE Krueppel-like factor 11 OS=Mus musculus OX=10090 GN=Klf11 PE=2 SV=3
MHSPGSTGPGDGRAADIMDICESILERKRHDSERSTCSVLEQTDIEAVEALVCMSSWGQR
SQMRPLTPVSDSGDVTTAVLMDTAAPDLPKDFHSFSTLCITPPQSPELTEPSTGTPVPSQ
VVNSKGCMVTALPPSPAGGPRTLSKREPLEPASGSSCRAVMTSVIRHTGESPAPTRFPTG
PTQEQRASDSGEGQERLLDHLEALQDTRLANGLLVTNLVSCQPCLHKSGGSFPTDKGQQT
GWPAAVQTCLPKNPESDLSRKITPLISVPVSSPPVLCQMIPVAGQNGLFSAFLKPPTQLP
AGTIKPILPQAASMSQPVFMGPPVPQGTVMLVLPQNTFPQPAACPSSVMAIGNTKLLPLA
PAPVFLASSQNCAPQVDFSRRRNYVCNFPGCRKTYFKSSHLKAHLRTHTGEKPFTCSWDG
CDKKFARSDELSRHRRTHTGEKKFVCPVCDRRFMRSDHLTKHARRHMTTKKIPGWQAEVG
KLNRITLAESPGSILEPLPASG

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History
Entry version 127 (07 Nov 2018)
Sequence version 3 (02 Sep 2008)
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Protein

Krueppel-like factor 11

Gene

Klf11

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	384 – 408	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	414 – 438	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	444 – 466	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 15820306
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14697507
DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
metal ion binding Source: UniProtKB-KW
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cellular response to peptide Source: Ensembl
negative regulation of cell proliferation Source: MGI
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 14697507
negative regulation of transcription by RNA polymerase II Source: MGI
positive regulation of apoptotic process Source: MGI
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription involved in G1/S transition of mitotic cell cycle Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Apoptosis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 11 Alternative name(s): TGFB-inducible early growth response protein 2b Transforming growth factor-beta-inducible early growth response protein 31 Publication Short name: TGFB-inducible early growth response protein 31 Publication Short name: TIEG-31 Publication
Gene namesⁱ	Name:Klf11Imported Synonyms:Tieg2bImported, Tieg3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:2653368 Klf11

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047189	1 – 502	Krueppel-like factor 11Add BLAST		502

Proteomic databases

PaxDbⁱ	Q8K1S5
PRIDEⁱ	Q8K1S5

PTM databases

PhosphoSitePlusⁱ	Q8K1S5

PhosphoSitePlusⁱ

Q8K1S5

Expressionⁱ

Inductionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020653 Expressed in 214 organ(s), highest expression level in embryo
CleanExⁱ	MM_KLF11
ExpressionAtlasⁱ	Q8K1S5 baseline and differential
Genevisibleⁱ	Q8K1S5 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SIN3A.By similarity

Protein-protein interaction databases

BioGridⁱ	228800, 1 interactor
STRINGⁱ	10090.ENSMUSP00000020982

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K1S5
SMRⁱ	Q8K1S5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Sequence analysis

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	384 – 408	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	414 – 438	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	444 – 466	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000059558
HOVERGENⁱ	HBG052264
InParanoidⁱ	Q8K1S5
KEGG Orthology (KO) More...KOⁱ	K09209
OMAⁱ	CMTPPQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q8K1S5
TreeFamⁱ	TF315506

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8K1S5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA 
        60         70         80         90        100
LVCMSSWGQR SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI 
       110        120        130        140        150
TPPQSPELTE PSTGTPVPSQ VVNSKGCMVT ALPPSPAGGP RTLSKREPLE 
       160        170        180        190        200
PASGSSCRAV MTSVIRHTGE SPAPTRFPTG PTQEQRASDS GEGQERLLDH 
       210        220        230        240        250
LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT GWPAAVQTCL 
       260        270        280        290        300
PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP 
       310        320        330        340        350
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA 
       360        370        380        390        400
IGNTKLLPLA PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH 
       410        420        430        440        450
LKAHLRTHTG EKPFTCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD 
       460        470        480        490        500
RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRITLAES PGSILEPLPA 

SG

Length:502

Mass (Da):54,054

Last modified:September 2, 2008 - v3

Checksum:ⁱ158CD440B487F735

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z0S4	D3Z0S4_MOUSE	Krueppel-like factor 11 Krueppel-like factor 11	Klf11	181	Annotation score:
D3Z293	D3Z293_MOUSE	Krueppel-like factor 11 Krueppel-like factor 11	Klf11	179	Annotation score:
D3YZX6	D3YZX6_MOUSE	Krueppel-like factor 11 Krueppel-like factor 11	Klf11	81	Annotation score:

Sequence cautionⁱ

The sequence BAC34099 differs from that shown. Reason: Frameshift at position 108.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	262 – 263	IT → TA in CAD30835 (PubMed:14697507).Curated	2
Sequence conflictⁱ	262 – 263	IT → TA in BAC40717 (PubMed:16141072).Curated	2
Sequence conflictⁱ	368	S → P in CAD30835 (PubMed:14697507).Curated	1
Sequence conflictⁱ	373	A → V in CAD30835 (PubMed:14697507).Curated	1
Sequence conflictⁱ	373	A → V in BAC40717 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ459773 mRNA Translation: CAD30835.1 AK036618 mRNA Translation: BAC29509.1 AK038397 mRNA Translation: BAC29984.1 AK050156 mRNA Translation: BAC34099.1 Frameshift. AK054170 mRNA Translation: BAC35678.1 AK082838 mRNA Translation: BAC38647.1 AK084913 mRNA Translation: BAC39307.1 AK089044 mRNA Translation: BAC40717.1 AK161233 mRNA Translation: BAE36256.1 BC060642 mRNA Translation: AAH60642.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25842.1
NCBI Reference Sequences More...RefSeqⁱ	NP_848134.1, NM_178357.3
UniGeneⁱ	Mm.9616

Genome annotation databases

Ensemblⁱ	ENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653
GeneIDⁱ	194655
KEGGⁱ	mmu:194655
UCSC genome browser More...UCSCⁱ	uc007neo.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K1S5	Krueppel-like factor 11 (Fragment)		MOUSE		179	UniRef100_Q8K1S5
Krueppel-like factor 11 (Fragment)		MOUSE		81
Krueppel-like factor 11 (Fragment)		MOUSE		181

Protein	Similar proteins		Species	Score	Length	Source
Q8K1S5	Krueppel-like factor 11 (Fragment)		MOUSE		179	UniRef90_Q8K1S5
Kruppel-like factor 11		RAT		501
UPI000A306809		MUSPA		502
UPI000A315B1C		MUSCR		502
Krueppel-like factor 11 (Fragment)		MOUSE		81
+2

Protein	Similar proteins		Species	Score	Length	Source
Q8K1S5	Krueppel-like factor 11	)	HUMAN		512	UniRef50_O14901
KLF11 isoform 6 (Fragment)		PANTR		122
Uncharacterized protein		CERAT		513
Uncharacterized protein		MACMU		512
Uncharacterized protein		MACFA		512
+163

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ459773 mRNA Translation: CAD30835.1 AK036618 mRNA Translation: BAC29509.1 AK038397 mRNA Translation: BAC29984.1 AK050156 mRNA Translation: BAC34099.1 Frameshift. AK054170 mRNA Translation: BAC35678.1 AK082838 mRNA Translation: BAC38647.1 AK084913 mRNA Translation: BAC39307.1 AK089044 mRNA Translation: BAC40717.1 AK161233 mRNA Translation: BAE36256.1 BC060642 mRNA Translation: AAH60642.1
CCDSⁱ	CCDS25842.1
RefSeqⁱ	NP_848134.1, NM_178357.3
UniGeneⁱ	Mm.9616

3D structure databases

ProteinModelPortalⁱ	Q8K1S5
SMRⁱ	Q8K1S5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	228800, 1 interactor
STRINGⁱ	10090.ENSMUSP00000020982

PTM databases

PhosphoSitePlusⁱ	Q8K1S5

PhosphoSitePlusⁱ

Q8K1S5

Proteomic databases

PaxDbⁱ	Q8K1S5
PRIDEⁱ	Q8K1S5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653
GeneIDⁱ	194655
KEGGⁱ	mmu:194655
UCSCⁱ	uc007neo.2 mouse

Organism-specific databases

CTDⁱ	8462
MGIⁱ	MGI:2653368 Klf11

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000059558
HOVERGENⁱ	HBG052264
InParanoidⁱ	Q8K1S5
KOⁱ	K09209
OMAⁱ	CMTPPQS
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	Q8K1S5
TreeFamⁱ	TF315506

Miscellaneous databases

ChiTaRSⁱ	Klf11 mouse
Protein Ontology More...PROⁱ	PR:Q8K1S5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020653 Expressed in 214 organ(s), highest expression level in embryo
CleanExⁱ	MM_KLF11
ExpressionAtlasⁱ	Q8K1S5 baseline and differential
Genevisibleⁱ	Q8K1S5 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF11_MOUSE
Accessionⁱ	Q8K1S5Primary (citable) accession number: Q8K1S5 Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	September 2, 2008
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K1S5 (KLF11_MOUSE)

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Krueppel-like factor 11

Klf11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ