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UniProtKB - Q8K1S5 (KLF11_MOUSE)
Protein
Krueppel-like factor 11
Gene
Klf11
Organism
Mus musculus (Mouse)
Status
Functioni
Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity).
Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
By similarity2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 408 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 414 – 438 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 444 – 466 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to peptide Source: Ensembl
- negative regulation of cell population proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of apoptotic process Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 11Alternative name(s): TGFB-inducible early growth response protein 2b Transforming growth factor-beta-inducible early growth response protein 31 Publication Short name: TGFB-inducible early growth response protein 31 Publication Short name: TIEG-31 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2653368, Klf11 |
VEuPathDBi | HostDB:ENSMUSG00000020653 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- focal adhesion Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047189 | 1 – 502 | Krueppel-like factor 11Add BLAST | 502 |
Proteomic databases
PaxDbi | Q8K1S5 |
PRIDEi | Q8K1S5 |
PTM databases
iPTMneti | Q8K1S5 |
PhosphoSitePlusi | Q8K1S5 |
Expressioni
Inductioni
By TGF-beta. Expressed in a circadian manner in the kidney and epididymal fat tissue.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000020653, Expressed in embryo and 240 other tissues |
ExpressionAtlasi | Q8K1S5, baseline and differential |
Genevisiblei | Q8K1S5, MM |
Interactioni
Subunit structurei
Interacts with SIN3A.
By similarityProtein-protein interaction databases
BioGRIDi | 228800, 1 interactor |
STRINGi | 10090.ENSMUSP00000020982 |
Miscellaneous databases
RNActi | Q8K1S5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 133 – 156 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 169 – 194 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Sequence analysis
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 384 – 408 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 414 – 438 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 444 – 466 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
InParanoidi | Q8K1S5 |
OMAi | CITNTPQ |
OrthoDBi | 582598at2759 |
PhylomeDBi | Q8K1S5 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8K1S5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSPGSTGPG DGRAADIMDI CESILERKRH DSERSTCSVL EQTDIEAVEA
60 70 80 90 100
LVCMSSWGQR SQMRPLTPVS DSGDVTTAVL MDTAAPDLPK DFHSFSTLCI
110 120 130 140 150
TPPQSPELTE PSTGTPVPSQ VVNSKGCMVT ALPPSPAGGP RTLSKREPLE
160 170 180 190 200
PASGSSCRAV MTSVIRHTGE SPAPTRFPTG PTQEQRASDS GEGQERLLDH
210 220 230 240 250
LEALQDTRLA NGLLVTNLVS CQPCLHKSGG SFPTDKGQQT GWPAAVQTCL
260 270 280 290 300
PKNPESDLSR KITPLISVPV SSPPVLCQMI PVAGQNGLFS AFLKPPTQLP
310 320 330 340 350
AGTIKPILPQ AASMSQPVFM GPPVPQGTVM LVLPQNTFPQ PAACPSSVMA
360 370 380 390 400
IGNTKLLPLA PAPVFLASSQ NCAPQVDFSR RRNYVCNFPG CRKTYFKSSH
410 420 430 440 450
LKAHLRTHTG EKPFTCSWDG CDKKFARSDE LSRHRRTHTG EKKFVCPVCD
460 470 480 490 500
RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRITLAES PGSILEPLPA
SG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z0S4 | D3Z0S4_MOUSE | Krueppel-like factor 11 | Klf11 | 181 | Annotation score: | ||
D3Z293 | D3Z293_MOUSE | Krueppel-like factor 11 | Klf11 | 179 | Annotation score: | ||
D3YZX6 | D3YZX6_MOUSE | Krueppel-like factor 11 | Klf11 | 81 | Annotation score: |
Sequence cautioni
The sequence BAC34099 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 262 – 263 | IT → TA in CAD30835 (PubMed:14697507).Curated | 2 | |
Sequence conflicti | 262 – 263 | IT → TA in BAC40717 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 368 | S → P in CAD30835 (PubMed:14697507).Curated | 1 | |
Sequence conflicti | 373 | A → V in CAD30835 (PubMed:14697507).Curated | 1 | |
Sequence conflicti | 373 | A → V in BAC40717 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ459773 mRNA Translation: CAD30835.1 AK036618 mRNA Translation: BAC29509.1 AK038397 mRNA Translation: BAC29984.1 AK050156 mRNA Translation: BAC34099.1 Frameshift. AK054170 mRNA Translation: BAC35678.1 AK082838 mRNA Translation: BAC38647.1 AK084913 mRNA Translation: BAC39307.1 AK089044 mRNA Translation: BAC40717.1 AK161233 mRNA Translation: BAE36256.1 BC060642 mRNA Translation: AAH60642.1 |
CCDSi | CCDS25842.1 |
RefSeqi | NP_848134.1, NM_178357.3 |
Genome annotation databases
Ensembli | ENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653 |
GeneIDi | 194655 |
KEGGi | mmu:194655 |
UCSCi | uc007neo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ459773 mRNA Translation: CAD30835.1 AK036618 mRNA Translation: BAC29509.1 AK038397 mRNA Translation: BAC29984.1 AK050156 mRNA Translation: BAC34099.1 Frameshift. AK054170 mRNA Translation: BAC35678.1 AK082838 mRNA Translation: BAC38647.1 AK084913 mRNA Translation: BAC39307.1 AK089044 mRNA Translation: BAC40717.1 AK161233 mRNA Translation: BAE36256.1 BC060642 mRNA Translation: AAH60642.1 |
CCDSi | CCDS25842.1 |
RefSeqi | NP_848134.1, NM_178357.3 |
3D structure databases
SMRi | Q8K1S5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228800, 1 interactor |
STRINGi | 10090.ENSMUSP00000020982 |
PTM databases
iPTMneti | Q8K1S5 |
PhosphoSitePlusi | Q8K1S5 |
Proteomic databases
PaxDbi | Q8K1S5 |
PRIDEi | Q8K1S5 |
Protocols and materials databases
Antibodypediai | 12498, 358 antibodies from 32 providers |
DNASUi | 194655 |
Genome annotation databases
Ensembli | ENSMUST00000020982; ENSMUSP00000020982; ENSMUSG00000020653 |
GeneIDi | 194655 |
KEGGi | mmu:194655 |
UCSCi | uc007neo.2, mouse |
Organism-specific databases
CTDi | 8462 |
MGIi | MGI:2653368, Klf11 |
VEuPathDBi | HostDB:ENSMUSG00000020653 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
InParanoidi | Q8K1S5 |
OMAi | CITNTPQ |
OrthoDBi | 582598at2759 |
PhylomeDBi | Q8K1S5 |
TreeFami | TF315506 |
Miscellaneous databases
BioGRID-ORCSi | 194655, 0 hits in 65 CRISPR screens |
ChiTaRSi | Klf11, mouse |
PROi | PR:Q8K1S5 |
RNActi | Q8K1S5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020653, Expressed in embryo and 240 other tissues |
ExpressionAtlasi | Q8K1S5, baseline and differential |
Genevisiblei | Q8K1S5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF11_MOUSE | |
Accessioni | Q8K1S5Primary (citable) accession number: Q8K1S5 Secondary accession number(s): Q8BHJ1, Q8BI37, Q8BI70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | September 2, 2008 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families