UniProtKB - Q8K1Q0 (NMT1_RAT)
Protein
Glycylpeptide N-tetradecanoyltransferase 1
Gene
Nmt1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.By similarity
Catalytic activityi
- N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N-tetradecanoylglycyl-[protein]By similarityEC:2.3.1.97By similarity
GO - Molecular functioni
- glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB
- myristoyltransferase activity Source: RGD
GO - Biological processi
- cellular ketone metabolic process Source: RGD
- in utero embryonic development Source: RGD
- N-terminal peptidyl-glycine N-myristoylation Source: UniProtKB
- N-terminal protein myristoylation Source: RGD
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.3.1.97, 5301 |
Reactomei | R-RNO-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-RNO-75108, Activation, myristolyation of BID and translocation to mitochondria |
Names & Taxonomyi
Protein namesi | Recommended name: Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.97By similarity)Alternative name(s): Myristoyl-CoA:protein N-myristoyltransferase 1 Short name: NMT 1 Short name: Type I N-myristoyltransferase Peptide N-myristoyltransferase 1 |
Gene namesi | Name:Nmt1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628642, Nmt1 |
Subcellular locationi
Cytosol
- cytosol By similarity
Other locations
- Cytoplasm By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Copurifies with ribosomes.By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- extrinsic component of membrane Source: RGD
Keywords - Cellular componenti
Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064224 | 1 – 496 | Glycylpeptide N-tetradecanoyltransferase 1Add BLAST | 496 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 47 | PhosphoserineCombined sources | 1 | |
Modified residuei | 83 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8K1Q0 |
PaxDbi | Q8K1Q0 |
PRIDEi | Q8K1Q0 |
PTM databases
iPTMneti | Q8K1Q0 |
PhosphoSitePlusi | Q8K1Q0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002989, Expressed in brain and 22 other tissues |
Genevisiblei | Q8K1Q0, RN |
Interactioni
Protein-protein interaction databases
IntActi | Q8K1Q0, 4 interactors |
STRINGi | 10116.ENSRNOP00000004046 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 120 | Myristoyl-CoA bindingBy similarity | 3 | |
Regioni | 248 – 250 | Myristoyl-CoA bindingBy similarity | 3 | |
Regioni | 256 – 260 | Myristoyl-CoA bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the NMT family.Curated
Phylogenomic databases
eggNOGi | KOG2779, Eukaryota |
GeneTreei | ENSGT00390000017837 |
HOGENOMi | CLU_022882_1_0_1 |
InParanoidi | Q8K1Q0 |
OMAi | SHLARNM |
OrthoDBi | 1025421at2759 |
PhylomeDBi | Q8K1Q0 |
TreeFami | TF300701 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000903, MyristoylCoA_TrFase IPR022677, MyristoylCoA_TrFase_C IPR022678, MyristoylCoA_TrFase_CS IPR022676, MyristoylCoA_TrFase_N |
PANTHERi | PTHR11377, PTHR11377, 1 hit |
Pfami | View protein in Pfam PF01233, NMT, 1 hit PF02799, NMT_C, 1 hit |
PIRSFi | PIRSF015892, N-myristl_transf, 1 hit |
SUPFAMi | SSF55729, SSF55729, 2 hits |
PROSITEi | View protein in PROSITE PS00975, NMT_1, 1 hit PS00976, NMT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8K1Q0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDIS HNRGGLSPAN
60 70 80 90 100
DTGAKKKKKK QKKKKEKGND MDSTQDQPVK MNSLPAERIQ EIQKAIELFS
110 120 130 140 150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY
160 170 180 190 200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA
210 220 230 240 250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV
260 270 280 290 300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH
360 370 380 390 400
QLLSRYLKQF NLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF
410 420 430 440 450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF
460 470 480 490
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ492222 mRNA Translation: CAD37349.1 BC097277 mRNA Translation: AAH97277.1 |
RefSeqi | NP_683689.1, NM_148891.2 |
Genome annotation databases
Ensembli | ENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989 |
GeneIDi | 259274 |
KEGGi | rno:259274 |
UCSCi | RGD:628642, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ492222 mRNA Translation: CAD37349.1 BC097277 mRNA Translation: AAH97277.1 |
RefSeqi | NP_683689.1, NM_148891.2 |
3D structure databases
SMRi | Q8K1Q0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q8K1Q0, 4 interactors |
STRINGi | 10116.ENSRNOP00000004046 |
PTM databases
iPTMneti | Q8K1Q0 |
PhosphoSitePlusi | Q8K1Q0 |
Proteomic databases
jPOSTi | Q8K1Q0 |
PaxDbi | Q8K1Q0 |
PRIDEi | Q8K1Q0 |
Genome annotation databases
Ensembli | ENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989 |
GeneIDi | 259274 |
KEGGi | rno:259274 |
UCSCi | RGD:628642, rat |
Organism-specific databases
CTDi | 4836 |
RGDi | 628642, Nmt1 |
Phylogenomic databases
eggNOGi | KOG2779, Eukaryota |
GeneTreei | ENSGT00390000017837 |
HOGENOMi | CLU_022882_1_0_1 |
InParanoidi | Q8K1Q0 |
OMAi | SHLARNM |
OrthoDBi | 1025421at2759 |
PhylomeDBi | Q8K1Q0 |
TreeFami | TF300701 |
Enzyme and pathway databases
BRENDAi | 2.3.1.97, 5301 |
Reactomei | R-RNO-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-RNO-75108, Activation, myristolyation of BID and translocation to mitochondria |
Miscellaneous databases
PROi | PR:Q8K1Q0 |
Gene expression databases
Bgeei | ENSRNOG00000002989, Expressed in brain and 22 other tissues |
Genevisiblei | Q8K1Q0, RN |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000903, MyristoylCoA_TrFase IPR022677, MyristoylCoA_TrFase_C IPR022678, MyristoylCoA_TrFase_CS IPR022676, MyristoylCoA_TrFase_N |
PANTHERi | PTHR11377, PTHR11377, 1 hit |
Pfami | View protein in Pfam PF01233, NMT, 1 hit PF02799, NMT_C, 1 hit |
PIRSFi | PIRSF015892, N-myristl_transf, 1 hit |
SUPFAMi | SSF55729, SSF55729, 2 hits |
PROSITEi | View protein in PROSITE PS00975, NMT_1, 1 hit PS00976, NMT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NMT1_RAT | |
Accessioni | Q8K1Q0Primary (citable) accession number: Q8K1Q0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 13, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families