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UniProtKB - Q8K1Q0 (NMT1_RAT)

Entry version 112 (02 Dec 2020)
Sequence version 1 (01 Oct 2002)
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Protein

Glycylpeptide N-tetradecanoyltransferase 1

Gene

Nmt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.97, 5301

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-RNO-75108, Activation, myristolyation of BID and translocation to mitochondria

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferase 1 (EC:2.3.1.97By similarity)
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase 1
Short name:
NMT 1
Short name:
Type I N-myristoyltransferase
Peptide N-myristoyltransferase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nmt1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Rat genome database

More...RGDi		628642, Nmt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642241 – 496Glycylpeptide N-tetradecanoyltransferase 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei31PhosphoserineBy similarity1
Modified residuei47PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8K1Q0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8K1Q0

PRoteomics IDEntifications database

More...PRIDEi		Q8K1Q0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8K1Q0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8K1Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000002989, Expressed in brain and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8K1Q0, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q8K1Q0, 4 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000004046

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8K1Q0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 120Myristoyl-CoA bindingBy similarity3
Regioni248 – 250Myristoyl-CoA bindingBy similarity3
Regioni256 – 260Myristoyl-CoA bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NMT family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2779, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022882_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8K1Q0

Identification of Orthologs from Complete Genome Data

More...OMAi		SHLARNM

Database of Orthologous Groups

More...OrthoDBi		1025421at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8K1Q0

TreeFam database of animal gene trees

More...TreeFami		TF300701

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N

The PANTHER Classification System

More...PANTHERi		PTHR11377, PTHR11377, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015892, N-myristl_transf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55729, SSF55729, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8K1Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDIS HNRGGLSPAN 
        60         70         80         90        100
DTGAKKKKKK QKKKKEKGND MDSTQDQPVK MNSLPAERIQ EIQKAIELFS 
       110        120        130        140        150
VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY 
       160        170        180        190        200
TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA 
       210        220        230        240        250
LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV 
       260        270        280        290        300
HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS 
       310        320        330        340        350
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH 
       360        370        380        390        400
QLLSRYLKQF NLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF 
       410        420        430        440        450
YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF 
       460        470        480        490 
NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
Length:496
Mass (Da):56,860
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A7EE954E0D0156A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ492222 mRNA Translation: CAD37349.1
BC097277 mRNA Translation: AAH97277.1

NCBI Reference Sequences

More...RefSeqi		NP_683689.1, NM_148891.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989

Database of genes from NCBI RefSeq genomes

More...GeneIDi		259274

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:259274

UCSC genome browser

More...UCSCi		RGD:628642, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492222 mRNA Translation: CAD37349.1
BC097277 mRNA Translation: AAH97277.1
RefSeqiNP_683689.1, NM_148891.2

3D structure databases

SMRiQ8K1Q0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8K1Q0, 4 interactors
STRINGi10116.ENSRNOP00000004046

PTM databases

iPTMnetiQ8K1Q0
PhosphoSitePlusiQ8K1Q0

Proteomic databases

jPOSTiQ8K1Q0
PaxDbiQ8K1Q0
PRIDEiQ8K1Q0

Genome annotation databases

EnsembliENSRNOT00000004046; ENSRNOP00000004046; ENSRNOG00000002989
GeneIDi259274
KEGGirno:259274
UCSCiRGD:628642, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4836
RGDi628642, Nmt1

Phylogenomic databases

eggNOGiKOG2779, Eukaryota
GeneTreeiENSGT00390000017837
HOGENOMiCLU_022882_1_0_1
InParanoidiQ8K1Q0
OMAiSHLARNM
OrthoDBi1025421at2759
PhylomeDBiQ8K1Q0
TreeFamiTF300701

Enzyme and pathway databases

BRENDAi2.3.1.97, 5301
ReactomeiR-RNO-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-RNO-75108, Activation, myristolyation of BID and translocation to mitochondria

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q8K1Q0

Gene expression databases

BgeeiENSRNOG00000002989, Expressed in brain and 22 other tissues
GenevisibleiQ8K1Q0, RN

Family and domain databases

InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N
PANTHERiPTHR11377, PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit
PIRSFiPIRSF015892, N-myristl_transf, 1 hit
SUPFAMiSSF55729, SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMT1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K1Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: December 2, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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