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Protein

Zinc finger protein GLIS1

Gene

Glis1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri366 – 391C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri400 – 427C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri433 – 457C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri463 – 487C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri493 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gli homologous protein 1
Short name:
GliH1
Gene namesi
Name:Glis1Imported
Synonyms:Gli5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2386723 Glis1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472101 – 789Zinc finger protein GLIS1Add BLAST789

Proteomic databases

PaxDbiQ8K1M4
PRIDEiQ8K1M4

PTM databases

iPTMnetiQ8K1M4
PhosphoSitePlusiQ8K1M4

Expressioni

Tissue specificityi

In the adult, expressed highly in placenta and kidney and at lower levels in the testis, brain, colon, brown fat tissue and thymus. During embryo development, expressed in the frontal nasal region, branchial arches, somites, vibrissal and hair follicles, limb buds, craniofacial regions, ventral part of the tail, intervertebral disks, teeth, eyes and kidney.2 Publications

Developmental stagei

In the embryo, expression is detected at 10 dpc becoming stronger by 11 dpc and continuing through to 16.5 dpc.2 Publications

Gene expression databases

BgeeiENSMUSG00000034762 Expressed in 135 organ(s), highest expression level in embryo
CleanExiMM_GLIS1
ExpressionAtlasiQ8K1M4 baseline and differential
GenevisibleiQ8K1M4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035650

Structurei

3D structure databases

ProteinModelPortaliQ8K1M4
SMRiQ8K1M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi511 – 527Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi627 – 680Pro-richAdd BLAST54

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri366 – 391C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri400 – 427C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri433 – 457C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri463 – 487C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri493 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000231136
HOVERGENiHBG051736
InParanoidiQ8K1M4
KOiK09232
OMAiKPPYPPF
OrthoDBiEOG091G0IZP
PhylomeDBiQ8K1M4
TreeFamiTF350216

Family and domain databases

InterProiView protein in InterPro
IPR030430 GLIS1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF93 PTHR19818:SF93, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8K1M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHCEVAEALS DKRPKEAPGA PGQGRGPVSL GAHMAFRIAV SGGGCGDGNP
60 70 80 90 100
LDLLPRLPVP PPRAHDLLRP RSPRDYGVSK TGSGKVNGSY GHSSEKSLLD
110 120 130 140 150
LDLAEGPSPS CHQGLFLPAG TPPPRGHPPV CEKLLHFPHP NRSPRPQATF
160 170 180 190 200
VNGSLPAAQH IKQEALPDYQ AMVSAHTPLP THCRAPSSMG LPSDLDFPDR
210 220 230 240 250
GLTNPAPSCY LLGNEPISDL GPQPEAHLPE GSLKRCCLLG LPPTSSASSS
260 270 280 290 300
PCASSDINPV IHSSQTALVS CVNGLRSPPL PGDLGGPPKR SRPGPASSDG
310 320 330 340 350
QEGSLQLEAC RKSGFLKQEP MDEFSELFAP HHQGLPPPYP LPQLPTGPGL
360 370 380 390 400
GGLGLGLAGR MVAGRQACRW VDCCAAYEQQ EELVRHIEKS HIDQRKGEDF
410 420 430 440 450
TCFWAGCVRR YKPFNARYKL LIHMRVHSGE KPNKCMFEGC SKAFSRLENL
460 470 480 490 500
KIHLRSHTGE KPYLCQHPGC QKAFSNSSDR AKHQRTHLDT KPYACQIPGC
510 520 530 540 550
SKRYTDPSSL RKHVKAHSAK EQQVRKKLHT GADPEADVLS ECLSLQQLQA
560 570 580 590 600
STLLPASRGK GSQTLSQELL PGVYPGSVTP QNGLASGILS PSHDVPSRHH
610 620 630 640 650
PLEVPTGSHH HLSPLPTAES TRDGLGPSLL SPMVSPLKGL GPPPLPPASQ
660 670 680 690 700
SQSPGGQSFS TVPSKPTYPS FQSPPPLPSP QGYQGSFHSI QNCFPYADCY
710 720 730 740 750
RATEPAASRD GLVGDAHGFN PLRPSTYSSL STPLSAPGYE TLAETPCPPA
760 770 780
LQPQPAEDLV PSGPEDCGFF PNGAFDHCLS HIPSIYTDT
Length:789
Mass (Da):84,172
Last modified:December 21, 2004 - v2
Checksum:i98D87D9EA20D38FD
GO
Isoform 21 Publication (identifier: Q8K1M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:618
Mass (Da):66,209
Checksum:i25055F3D35CECBF1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ASP5B1ASP5_MOUSE
Zinc finger protein GLIS1
Glis1
601Annotation score:
A2A8S0A2A8S0_MOUSE
Zinc finger protein GLIS1
Glis1
104Annotation score:

Sequence cautioni

The sequence AAH66157 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173V → A in AAM93156 (PubMed:12042312).Curated1
Sequence conflicti354G → R in AAM93156 (PubMed:12042312).Curated1
Sequence conflicti378E → G in AAH66157 (PubMed:15489334).Curated1
Sequence conflicti384V → E in AAH66157 (PubMed:15489334).Curated1
Sequence conflicti466Q → R in AAM93156 (PubMed:12042312).Curated1
Sequence conflicti634V → A in AAH66157 (PubMed:15489334).Curated1
Sequence conflicti668Y → S in AAH66157 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0516231 – 171Missing in isoform 2. 1 PublicationAdd BLAST171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486579 mRNA Translation: AAM93156.1
AF220434 mRNA Translation: AAM12150.1
BC066157 mRNA Translation: AAH66157.1 Different initiation.
CCDSiCCDS38831.1 [Q8K1M4-1]
RefSeqiNP_671754.2, NM_147221.2 [Q8K1M4-1]
XP_006503036.1, XM_006502973.3 [Q8K1M4-1]
XP_006503037.1, XM_006502974.3 [Q8K1M4-1]
XP_006503038.1, XM_006502975.1 [Q8K1M4-1]
UniGeneiMm.331757

Genome annotation databases

EnsembliENSMUST00000046005; ENSMUSP00000035650; ENSMUSG00000034762 [Q8K1M4-1]
GeneIDi230587
KEGGimmu:230587
UCSCiuc008tzv.1 mouse [Q8K1M4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486579 mRNA Translation: AAM93156.1
AF220434 mRNA Translation: AAM12150.1
BC066157 mRNA Translation: AAH66157.1 Different initiation.
CCDSiCCDS38831.1 [Q8K1M4-1]
RefSeqiNP_671754.2, NM_147221.2 [Q8K1M4-1]
XP_006503036.1, XM_006502973.3 [Q8K1M4-1]
XP_006503037.1, XM_006502974.3 [Q8K1M4-1]
XP_006503038.1, XM_006502975.1 [Q8K1M4-1]
UniGeneiMm.331757

3D structure databases

ProteinModelPortaliQ8K1M4
SMRiQ8K1M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035650

PTM databases

iPTMnetiQ8K1M4
PhosphoSitePlusiQ8K1M4

Proteomic databases

PaxDbiQ8K1M4
PRIDEiQ8K1M4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046005; ENSMUSP00000035650; ENSMUSG00000034762 [Q8K1M4-1]
GeneIDi230587
KEGGimmu:230587
UCSCiuc008tzv.1 mouse [Q8K1M4-1]

Organism-specific databases

CTDi148979
MGIiMGI:2386723 Glis1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140802
HOGENOMiHOG000231136
HOVERGENiHBG051736
InParanoidiQ8K1M4
KOiK09232
OMAiKPPYPPF
OrthoDBiEOG091G0IZP
PhylomeDBiQ8K1M4
TreeFamiTF350216

Miscellaneous databases

ChiTaRSiGlis1 mouse
PROiPR:Q8K1M4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034762 Expressed in 135 organ(s), highest expression level in embryo
CleanExiMM_GLIS1
ExpressionAtlasiQ8K1M4 baseline and differential
GenevisibleiQ8K1M4 MM

Family and domain databases

InterProiView protein in InterPro
IPR030430 GLIS1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR19818:SF93 PTHR19818:SF93, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLIS1_MOUSE
AccessioniPrimary (citable) accession number: Q8K1M4
Secondary accession number(s): Q6NZF6, Q8R4Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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