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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

Creb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the cAMP response element and activates transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene namesi
Name:Creb5
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2443973 Creb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766051 – 357Cyclic AMP-responsive element-binding protein 5Add BLAST357

Proteomic databases

PaxDbiQ8K1L0
PeptideAtlasiQ8K1L0
PRIDEiQ8K1L0

PTM databases

PhosphoSitePlusiQ8K1L0

Expressioni

Gene expression databases

CleanExiMM_CREB5

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038532

Structurei

3D structure databases

ProteinModelPortaliQ8K1L0
SMRiQ8K1L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 287bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni226 – 246Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni252 – 280Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 185His-richAdd BLAST66
Compositional biasi214 – 217Poly-Arg4

Sequence similaritiesi

Belongs to the bZIP family.UniRule annotationCurated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
HOGENOMiHOG000220894
HOVERGENiHBG004300
InParanoidiQ8K1L0
KOiK09047
PhylomeDBiQ8K1L0

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016378 TF_CRE-BP1-typ
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PIRSFiPIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K1L0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMRPVPGSL SSLLHLHNRQ RQPMPASMPG TLPNPTMPGS SAVLMPMERQ
60 70 80 90 100
MSVNSSIMGM QGPNLSNPCA SPQVQPMHSE AKMRLKAALT HHPAAMSNGN
110 120 130 140 150
MSTIGHMMEM MGSRQDQTPH HHLHSHPHQH QTLPPHHPYP HQHQHPAHHP
160 170 180 190 200
HPQPHHQQNH PHHHSHSHLH AHPAHHQTSP HPPLHTGNQA QVSPATQQMQ
210 220 230 240 250
PTQTIQPPQP TGGRRRRVVD EDPDERRRKF LERNRAAATR CRQKRKVWVM
260 270 280 290 300
SLEKKAEELT QTNMQLQNEV SMLKNEVAQL KQLLLTHKDC PITAMQKESQ
310 320 330 340 350
GYLSPESSPP ASPVPACSQQ QVIQHNTITT SSSVSEVVGS STLSQLTTHR

TDLNPIL
Length:357
Mass (Da):39,955
Last modified:December 12, 2006 - v3
Checksum:i526F9818C81D7FB7
GO
Isoform 2 (identifier: Q8K1L0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MSMR → MNLEQERPFV...QAPSTNRQIG
     84-97: RLKAALTHHPAAMS → NLHRPSPLALCLHS
     98-357: Missing.

Show »
Length:241
Mass (Da):26,552
Checksum:iD155AC1E60FAFD99
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV71A0A0N4SV71_MOUSE
Cyclic AMP-responsive element-bindi...
Creb5
501Annotation score:
A0A0N4SUW5A0A0N4SUW5_MOUSE
Cyclic AMP-responsive element-bindi...
Creb5
508Annotation score:
A0A0N4SUK5A0A0N4SUK5_MOUSE
Cyclic AMP-responsive element-bindi...
Creb5
357Annotation score:
A0A0N4SV26A0A0N4SV26_MOUSE
Cyclic AMP-responsive element-bindi...
Creb5
55Annotation score:

Sequence cautioni

The sequence AAH29022 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185H → P in BAC34998 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0220611 – 4MSMR → MNLEQERPFVCSAPGCSQRF PTEDHLMIHRHKHEMTLKFP SIKTDNMLSDQTPTPTRFLK NCEEVGLFSELDCSFEHEFR KAQEEENSKRNISMHNTVGG TMTGPGAHQLGSTRMPNHDS SVVIQQAMPSPQSSSVITQA PSTNRQIG in isoform 2. 1 Publication4
Alternative sequenceiVSP_02206284 – 97RLKAA…PAAMS → NLHRPSPLALCLHS in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_02206398 – 357Missing in isoform 2. 1 PublicationAdd BLAST260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052451 mRNA Translation: BAC34998.1
AK154148 mRNA Translation: BAE32408.1
AK155537 mRNA Translation: BAE33314.1
AK170766 mRNA Translation: BAE42016.1
BC029022 mRNA Translation: AAH29022.1 Different initiation.
CCDSiCCDS20153.1 [Q8K1L0-1]
RefSeqiNP_001314750.1, NM_001327821.1
NP_766316.1, NM_172728.2
UniGeneiMm.227444
Mm.258498
Mm.321138

Genome annotation databases

GeneIDi231991
KEGGimmu:231991
UCSCiuc009bzf.2 mouse [Q8K1L0-2]
uc009bzi.1 mouse [Q8K1L0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052451 mRNA Translation: BAC34998.1
AK154148 mRNA Translation: BAE32408.1
AK155537 mRNA Translation: BAE33314.1
AK170766 mRNA Translation: BAE42016.1
BC029022 mRNA Translation: AAH29022.1 Different initiation.
CCDSiCCDS20153.1 [Q8K1L0-1]
RefSeqiNP_001314750.1, NM_001327821.1
NP_766316.1, NM_172728.2
UniGeneiMm.227444
Mm.258498
Mm.321138

3D structure databases

ProteinModelPortaliQ8K1L0
SMRiQ8K1L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038532

PTM databases

PhosphoSitePlusiQ8K1L0

Proteomic databases

PaxDbiQ8K1L0
PeptideAtlasiQ8K1L0
PRIDEiQ8K1L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231991
KEGGimmu:231991
UCSCiuc009bzf.2 mouse [Q8K1L0-2]
uc009bzi.1 mouse [Q8K1L0-1]

Organism-specific databases

CTDi9586
MGIiMGI:2443973 Creb5

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
HOGENOMiHOG000220894
HOVERGENiHBG004300
InParanoidiQ8K1L0
KOiK09047
PhylomeDBiQ8K1L0

Miscellaneous databases

PROiPR:Q8K1L0
SOURCEiSearch...

Gene expression databases

CleanExiMM_CREB5

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR016378 TF_CRE-BP1-typ
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PIRSFiPIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCREB5_MOUSE
AccessioniPrimary (citable) accession number: Q8K1L0
Secondary accession number(s): Q3TCE1, Q3U228, Q8BWH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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