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UniProtKB - Q8K1L0 (CREB5_MOUSE)
Protein
Cyclic AMP-responsive element-binding protein 5
Gene
Creb5
Organism
Mus musculus (Mouse)
Status
Functioni
Binds to the cAMP response element and activates transcription.
By similarityGO - Molecular functioni
- cAMP response element binding Source: GO_Central
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- adipose tissue development Source: MGI
- fat cell differentiation Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- white fat cell differentiation Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-responsive element-binding protein 5Short name: CREB-5 Short name: cAMP-responsive element-binding protein 5 Alternative name(s): CRE-BPa |
Gene namesi | Name:Creb5 |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443973, Creb5 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076605 | 1 – 357 | Cyclic AMP-responsive element-binding protein 5Add BLAST | 357 |
Proteomic databases
MaxQBi | Q8K1L0 |
PaxDbi | Q8K1L0 |
PeptideAtlasi | Q8K1L0 |
PRIDEi | Q8K1L0 |
ProteomicsDBi | 277892 [Q8K1L0-1] 277893 [Q8K1L0-2] |
PTM databases
PhosphoSitePlusi | Q8K1L0 |
Interactioni
Subunit structurei
Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 231205, 2 interactors |
STRINGi | 10090.ENSMUSP00000038532 |
Miscellaneous databases
RNActi | Q8K1L0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 224 – 287 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 114 – 239 | DisorderedSequence analysisAdd BLAST | 126 | |
Regioni | 226 – 246 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 252 – 280 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 | |
Regioni | 298 – 318 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 175 | Basic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 181 – 210 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 214 – 238 | Basic and acidic residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
InParanoidi | Q8K1L0 |
OrthoDBi | 978850at2759 |
PhylomeDBi | Q8K1L0 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR016378, TF_CRE-BP1-typ |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PIRSFi | PIRSF003153, ATF2_CRE-BP1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8K1L0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMRPVPGSL SSLLHLHNRQ RQPMPASMPG TLPNPTMPGS SAVLMPMERQ
60 70 80 90 100
MSVNSSIMGM QGPNLSNPCA SPQVQPMHSE AKMRLKAALT HHPAAMSNGN
110 120 130 140 150
MSTIGHMMEM MGSRQDQTPH HHLHSHPHQH QTLPPHHPYP HQHQHPAHHP
160 170 180 190 200
HPQPHHQQNH PHHHSHSHLH AHPAHHQTSP HPPLHTGNQA QVSPATQQMQ
210 220 230 240 250
PTQTIQPPQP TGGRRRRVVD EDPDERRRKF LERNRAAATR CRQKRKVWVM
260 270 280 290 300
SLEKKAEELT QTNMQLQNEV SMLKNEVAQL KQLLLTHKDC PITAMQKESQ
310 320 330 340 350
GYLSPESSPP ASPVPACSQQ QVIQHNTITT SSSVSEVVGS STLSQLTTHR
TDLNPIL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SUW5 | A0A0N4SUW5_MOUSE | Cyclic AMP-responsive element-bindi... | Creb5 | 508 | Annotation score: | ||
A0A0N4SUK5 | A0A0N4SUK5_MOUSE | Cyclic AMP-responsive element-bindi... | Creb5 | 357 | Annotation score: | ||
A0A0N4SV71 | A0A0N4SV71_MOUSE | Cyclic AMP-responsive element-bindi... | Creb5 | 501 | Annotation score: | ||
A0A0N4SV26 | A0A0N4SV26_MOUSE | Cyclic AMP-responsive element-bindi... | Creb5 | 55 | Annotation score: |
Sequence cautioni
The sequence AAH29022 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 185 | H → P in BAC34998 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022061 | 1 – 4 | MSMR → MNLEQERPFVCSAPGCSQRF PTEDHLMIHRHKHEMTLKFP SIKTDNMLSDQTPTPTRFLK NCEEVGLFSELDCSFEHEFR KAQEEENSKRNISMHNTVGG TMTGPGAHQLGSTRMPNHDS SVVIQQAMPSPQSSSVITQA PSTNRQIG in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_022062 | 84 – 97 | RLKAA…PAAMS → NLHRPSPLALCLHS in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_022063 | 98 – 357 | Missing in isoform 2. 1 PublicationAdd BLAST | 260 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052451 mRNA Translation: BAC34998.1 AK154148 mRNA Translation: BAE32408.1 AK155537 mRNA Translation: BAE33314.1 AK170766 mRNA Translation: BAE42016.1 BC029022 mRNA Translation: AAH29022.1 Different initiation. |
CCDSi | CCDS20153.1 [Q8K1L0-1] |
RefSeqi | NP_001314750.1, NM_001327821.1 NP_766316.1, NM_172728.2 |
Genome annotation databases
GeneIDi | 231991 |
KEGGi | mmu:231991 |
UCSCi | uc009bzf.2, mouse [Q8K1L0-2] uc009bzi.1, mouse [Q8K1L0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052451 mRNA Translation: BAC34998.1 AK154148 mRNA Translation: BAE32408.1 AK155537 mRNA Translation: BAE33314.1 AK170766 mRNA Translation: BAE42016.1 BC029022 mRNA Translation: AAH29022.1 Different initiation. |
CCDSi | CCDS20153.1 [Q8K1L0-1] |
RefSeqi | NP_001314750.1, NM_001327821.1 NP_766316.1, NM_172728.2 |
3D structure databases
AlphaFoldDBi | Q8K1L0 |
SMRi | Q8K1L0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231205, 2 interactors |
STRINGi | 10090.ENSMUSP00000038532 |
PTM databases
PhosphoSitePlusi | Q8K1L0 |
Proteomic databases
MaxQBi | Q8K1L0 |
PaxDbi | Q8K1L0 |
PeptideAtlasi | Q8K1L0 |
PRIDEi | Q8K1L0 |
ProteomicsDBi | 277892 [Q8K1L0-1] 277893 [Q8K1L0-2] |
Protocols and materials databases
DNASUi | 231991 |
Genome annotation databases
GeneIDi | 231991 |
KEGGi | mmu:231991 |
UCSCi | uc009bzf.2, mouse [Q8K1L0-2] uc009bzi.1, mouse [Q8K1L0-1] |
Organism-specific databases
CTDi | 9586 |
MGIi | MGI:2443973, Creb5 |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
InParanoidi | Q8K1L0 |
OrthoDBi | 978850at2759 |
PhylomeDBi | Q8K1L0 |
Miscellaneous databases
BioGRID-ORCSi | 231991, 6 hits in 39 CRISPR screens |
ChiTaRSi | Creb5, mouse |
PROi | PR:Q8K1L0 |
RNActi | Q8K1L0, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR016378, TF_CRE-BP1-typ |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PIRSFi | PIRSF003153, ATF2_CRE-BP1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CREB5_MOUSE | |
Accessioni | Q8K1L0Primary (citable) accession number: Q8K1L0 Secondary accession number(s): Q3TCE1, Q3U228, Q8BWH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | December 12, 2006 | |
Last modified: | May 25, 2022 | |
This is version 132 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families