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Protein

Serpin B10

Gene

Serpinb10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362 – 363Reactive bondBy similarity2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.015

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B10
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2138648 Serpinb10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941151 – 397Serpin B10Add BLAST397

Proteomic databases

PRIDEiQ8K1K6

PTM databases

PhosphoSitePlusiQ8K1K6

Structurei

3D structure databases

ProteinModelPortaliQ8K1K6
SMRiQ8K1K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 77Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ8K1K6

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K1K6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLAVSINQ FALEFSKKLA ESAEGRNIFF SPWGISTALA MLYLGTKGTT
60 70 80 90 100
ADQMAQVLQF SSVEDFKSCP DSEKKRKMEF NSGKFEEIQS DFQTLAAEIL
110 120 130 140 150
KPGNSYVLKT ANRIYGEKTY PFHNKYLEDM KTYFGAEPQS VNFVEASGQI
160 170 180 190 200
RKEINSWVGS QTGGKIPNLL PDDSVDTKTK MVLVNALYFK GTWEHQFSVK
210 220 230 240 250
NTTERPFRVN KTTSKPVQMM SMKQSLQVFH IEELQTIGLQ LHYQNRDLSL
260 270 280 290 300
LLLLPEAIDG LEQLERAITY EKLDKWTSAD MMDTYEVQLY LPKFKMEESY
310 320 330 340 350
DLKSALRGMG MTDVFSQSKA DFSNMTSERN LFLSNVFHKT FLEINEEGTE
360 370 380 390
AAAGTGSEIS VRIKAPSIEL NVDHPFLFFI RHNKTKSILF CGRFCSP
Length:397
Mass (Da):45,115
Last modified:October 1, 2002 - v1
Checksum:iC9DE8E9A2248DA73
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UYR4G3UYR4_MOUSE
Serpin B10
Serpinb10
320Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029736 mRNA Translation: AAH29736.1
BC069938 mRNA Translation: AAH69938.1
UniGeneiMm.123919

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029736 mRNA Translation: AAH29736.1
BC069938 mRNA Translation: AAH69938.1
UniGeneiMm.123919

3D structure databases

ProteinModelPortaliQ8K1K6
SMRiQ8K1K6
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.015

PTM databases

PhosphoSitePlusiQ8K1K6

Proteomic databases

PRIDEiQ8K1K6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2138648 Serpinb10

Phylogenomic databases

HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiQ8K1K6

Miscellaneous databases

PROiPR:Q8K1K6
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB10_MOUSE
AccessioniPrimary (citable) accession number: Q8K1K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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