UniProtKB - Q8K1K3 (Q8K1K3_MOUSE)
Protein
Submitted name:
TERF1-interacting nuclear factor 2
Gene
Tinf2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- telomeric DNA binding Source: Ensembl
GO - Biological processi
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of protein ADP-ribosylation Source: Ensembl
- negative regulation of telomere maintenance via telomerase Source: Ensembl
- protein localization to chromosome, telomeric region Source: Ensembl
- telomere assembly Source: Ensembl
- telomere capping Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: TERF1-interacting nuclear factor 2ImportedSubmitted name: Terf1 (TRF1)-interacting nuclear factor 2Imported |
Gene namesi | Name:Tinf2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107246, Tinf2 |
Subcellular locationi
Nucleus
- nuclear body Source: Ensembl
- nuclear chromosome, telomeric region Source: Ensembl
- shelterin complex Source: Ensembl
Other locations
- perinucleolar chromocenter Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000007589, Expressed in secondary oocyte and 284 other tissues |
ExpressionAtlasi | Q8K1K3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 158 | TINF2_NInterPro annotationAdd BLAST | 139 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 283 – 348 | DisorderedSequence analysisAdd BLAST | 66 |
Phylogenomic databases
GeneTreei | ENSGT00400000022326 |
HOGENOMi | CLU_052191_0_0_1 |
OMAi | LIPTFCE |
TreeFami | TF334731 |
Family and domain databases
CDDi | cd11657, TIN2_N, 1 hit |
InterProi | View protein in InterPro IPR039098, TINF2 IPR029400, TINF2_N |
PANTHERi | PTHR15512, PTHR15512, 1 hit |
Pfami | View protein in Pfam PF14973, TINF2_N, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8K1K3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPPPGVGPA SLRFAAAASW LVVRRRRVEH FPKVVEFLQS LRAAAPGLVC
60 70 80 90 100
YRHHERLCMS LKAKVVVELI LQARPWDQVL NALKHHFPAE SRTTKEDRKL
110 120 130 140 150
LEARENFCLL VKHLSEDPPS SLQELEQDYG ESFLVAMEKL LFEYLCQLEK
160 170 180 190 200
ALPPVRAQEL QDALSWSQPG SFITSSVALH QYGMDMGWTF PESSTSGSGN
210 220 230 240 250
LIEPMEESPH QQTRPAFHSP LPKAKLGPHQ PASLEHPEHL AGHRFNLAPL
260 270 280 290 300
GKRKSRSHWT SAKACHKERP TVMLLPFRNM GLPAQDLSNP KSREEPGAAS
310 320 330 340 350
AASVGTEPVC TEEAKTPSRP LGKRALEETP PDSPAAEQEN SVNCVDPLRH
360 370 380 390 400
SSPPLTVKKP VLSPTPCSSV ITIGDLVLDS DEEENNQKEG KEFLKNYQKT
410
KFDTYIPMFC DYIP
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9QXG9 | TINF2_MOUSE | TERF1-interacting nuclear factor 2 | Tinf2 Tin2 | 341 | Annotation score: | ||
A0A2I3BRI7 | A0A2I3BRI7_MOUSE | TERF1-interacting nuclear factor 2 | Tinf2 | 197 | Annotation score: | ||
A0A2I3BRL3 | A0A2I3BRL3_MOUSE | TERF1-interacting nuclear factor 2 | Tinf2 | 419 | Annotation score: | ||
A0A2I3BPS4 | A0A2I3BPS4_MOUSE | TERF1-interacting nuclear factor 2 | Tinf2 | 149 | Annotation score: | ||
A0A2I3BRW2 | A0A2I3BRW2_MOUSE | TERF1-interacting nuclear factor 2 | Tinf2 | 73 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT025679 Genomic DNA No translation available. BC030347 mRNA Translation: AAH30347.1 AK037673 mRNA Translation: BAC29848.1 |
RefSeqi | NP_663751.2, NM_145705.3 |
Genome annotation databases
Ensembli | ENSMUST00000007733; ENSMUSP00000007733; ENSMUSG00000007589 |
GeneIDi | 28113 |
KEGGi | mmu:28113 |
UCSCi | uc007uaf.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT025679 Genomic DNA No translation available. BC030347 mRNA Translation: AAH30347.1 AK037673 mRNA Translation: BAC29848.1 |
RefSeqi | NP_663751.2, NM_145705.3 |
3D structure databases
SMRi | Q8K1K3 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q8K1K3 |
Protocols and materials databases
Antibodypediai | 22798, 223 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000007733; ENSMUSP00000007733; ENSMUSG00000007589 |
GeneIDi | 28113 |
KEGGi | mmu:28113 |
UCSCi | uc007uaf.3, mouse |
Organism-specific databases
CTDi | 26277 |
MGIi | MGI:107246, Tinf2 |
Phylogenomic databases
GeneTreei | ENSGT00400000022326 |
HOGENOMi | CLU_052191_0_0_1 |
OMAi | LIPTFCE |
TreeFami | TF334731 |
Miscellaneous databases
BioGRID-ORCSi | 28113, 7 hits in 17 CRISPR screens |
ChiTaRSi | Tinf2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000007589, Expressed in secondary oocyte and 284 other tissues |
ExpressionAtlasi | Q8K1K3, baseline and differential |
Family and domain databases
CDDi | cd11657, TIN2_N, 1 hit |
InterProi | View protein in InterPro IPR039098, TINF2 IPR029400, TINF2_N |
PANTHERi | PTHR15512, PTHR15512, 1 hit |
Pfami | View protein in Pfam PF14973, TINF2_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8K1K3_MOUSE | |
Accessioni | Q8K1K3Primary (citable) accession number: Q8K1K3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2002 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |