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Protein

Leucine-rich repeat-containing protein 41

Gene

Lrrc41

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Alternative name(s):
Protein Muf1
Gene namesi
Name:Lrrc41
Synonyms:Muf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2441984 Lrrc41

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46L → P: No association with Elongin BC complex; when associated with F-50. 1 Publication1
Mutagenesisi50C → F: No association with Elongin BC complex; when associated with P-46. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966461 – 807Leucine-rich repeat-containing protein 41Add BLAST807

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei326PhosphoserineBy similarity1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei368PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K1C9
MaxQBiQ8K1C9
PaxDbiQ8K1C9
PeptideAtlasiQ8K1C9
PRIDEiQ8K1C9

PTM databases

iPTMnetiQ8K1C9
PhosphoSitePlusiQ8K1C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028703 Expressed in 264 organ(s), highest expression level in retina
CleanExiMM_LRRC41
GenevisibleiQ8K1C9 MM

Interactioni

Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (ELOB and ELOC), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, ELOB and ELOC (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230994, 10 interactors
IntActiQ8K1C9, 4 interactors
STRINGi10090.ENSMUSP00000030471

Structurei

3D structure databases

ProteinModelPortaliQ8K1C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati482 – 502LRR 1Add BLAST21
Repeati513 – 525LRR 2Add BLAST13
Repeati526 – 550LRR 3Add BLAST25
Repeati608 – 632LRR 4Add BLAST25
Repeati638 – 661LRR 5Add BLAST24
Repeati696 – 723LRR 6Add BLAST28
Repeati726 – 747LRR 7Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 54Interaction with Elongin BC complexBy similarity10

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x3-C-x3-[AILV].

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHRR Eukaryota
ENOG410YFW5 LUCA
GeneTreeiENSGT00390000015908
HOGENOMiHOG000013094
HOVERGENiHBG102701
InParanoidiQ8K1C9
KOiK10347
OMAiNRLGNHR
OrthoDBiEOG091G02TR
PhylomeDBiQ8K1C9
TreeFamiTF335481

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K1C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP SAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDKRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGS LPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMATRRKSEV KQMPRAVPPT RVTRRSTQES LAIGGTDSKL YLPATSYEAS
360 370 380 390 400
GTKQPSAPAA ASASSSTSSK RAPASSASQP KPLKRFKRAA GKKGPRTRQG
410 420 430 440 450
SGAESEDLYD FVFIVAGEKE DGEEMEIGEV ACGALDGSDP SCLGLPALEA
460 470 480 490 500
SQRFRSISTL ELFTVPLSTE AALTLCHLLS SWVSLESLTL SYNGLGSNIF
510 520 530 540 550
RLLDSLRALS GQAGCRLRAL HLSDLFSPLP ILELTRAIVR ALPLLRVLSI
560 570 580 590 600
RVDHPSQRDN PAVPENAGPP GHIVGDEEIP ENCLEQLEMG FPRGAQPAPL
610 620 630 640 650
LCSVLKASGS LQQLSLDSAT FASPQDFGLV LQTLKEHNLS LKRLSFHDMN
660 670 680 690 700
LADCQSEVLF LLKNLTLQEI TFSFCRLFEK RPVQFLPEMV AAMKGNSTLK
710 720 730 740 750
GLRLPGNRLG NAGLLALADV FSEDSSSSLC QLDISSNCIK PDGLLEFAKR
760 770 780 790 800
LERWGRGAFG HLRLFQNWLD QDAVTAREAI RRLRATCHVV SDSWDSTQAF

ADYVSTM
Length:807
Mass (Da):88,180
Last modified:June 26, 2007 - v3
Checksum:i79F6BBF2D4A33B97
GO

Sequence cautioni

The sequence AAH22976 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42 – 50APPALFELC → RTRGSTHAS in AAH71258 (PubMed:15489334).Curated9
Sequence conflicti51G → E in BAE32713 (PubMed:16141072).Curated1
Sequence conflicti672F → Y in BAE32713 (PubMed:16141072).Curated1
Sequence conflicti733D → G in BAE32713 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154613 mRNA Translation: BAE32713.1
AL627105 Genomic DNA No translation available.
BC007169 mRNA Translation: AAH07169.1
BC022976 mRNA Translation: AAH22976.2 Different initiation.
BC071258 mRNA Translation: AAH71258.1
CCDSiCCDS84786.1
RefSeqiNP_705741.3, NM_153521.2
UniGeneiMm.260786
Mm.3655

Genome annotation databases

EnsembliENSMUST00000030471; ENSMUSP00000030471; ENSMUSG00000028703
GeneIDi230654
KEGGimmu:230654
UCSCiuc008ufx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154613 mRNA Translation: BAE32713.1
AL627105 Genomic DNA No translation available.
BC007169 mRNA Translation: AAH07169.1
BC022976 mRNA Translation: AAH22976.2 Different initiation.
BC071258 mRNA Translation: AAH71258.1
CCDSiCCDS84786.1
RefSeqiNP_705741.3, NM_153521.2
UniGeneiMm.260786
Mm.3655

3D structure databases

ProteinModelPortaliQ8K1C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230994, 10 interactors
IntActiQ8K1C9, 4 interactors
STRINGi10090.ENSMUSP00000030471

PTM databases

iPTMnetiQ8K1C9
PhosphoSitePlusiQ8K1C9

Proteomic databases

EPDiQ8K1C9
MaxQBiQ8K1C9
PaxDbiQ8K1C9
PeptideAtlasiQ8K1C9
PRIDEiQ8K1C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030471; ENSMUSP00000030471; ENSMUSG00000028703
GeneIDi230654
KEGGimmu:230654
UCSCiuc008ufx.1 mouse

Organism-specific databases

CTDi10489
MGIiMGI:2441984 Lrrc41

Phylogenomic databases

eggNOGiENOG410IHRR Eukaryota
ENOG410YFW5 LUCA
GeneTreeiENSGT00390000015908
HOGENOMiHOG000013094
HOVERGENiHBG102701
InParanoidiQ8K1C9
KOiK10347
OMAiNRLGNHR
OrthoDBiEOG091G02TR
PhylomeDBiQ8K1C9
TreeFamiTF335481

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiLrrc41 mouse
PROiPR:Q8K1C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028703 Expressed in 264 organ(s), highest expression level in retina
CleanExiMM_LRRC41
GenevisibleiQ8K1C9 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR026137 Leu_rpt_41
IPR032675 LRR_dom_sf
PANTHERiPTHR15354 PTHR15354, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLRC41_MOUSE
AccessioniPrimary (citable) accession number: Q8K1C9
Secondary accession number(s): A2A911
, Q3U3S2, Q6IQY7, Q91VX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 26, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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