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Entry version 110 (02 Jun 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Pleckstrin homology domain-containing family O member 2

Gene

Plekho2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family O member 2
Short name:
PH domain-containing family O member 2
Alternative name(s):
Pleckstrin homology domain-containing family Q member 1
Short name:
PH domain-containing family Q member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plekho2
Synonyms:Plekhq1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2143132, Plekho2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003094841 – 495Pleckstrin homology domain-containing family O member 2Add BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei165PhosphoserineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei233PhosphothreonineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei239PhosphoserineCombined sources1
Modified residuei274PhosphoserineBy similarity1
Modified residuei292PhosphoserineCombined sources1
Modified residuei296PhosphothreonineCombined sources1
Modified residuei395PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8K124

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K124

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8K124

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K124

PeptideAtlas

More...
PeptideAtlasi
Q8K124

PRoteomics IDEntifications database

More...
PRIDEi
Q8K124

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
289606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K124

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K124

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050721, Expressed in granulocyte and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8K124, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
221902, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8K124, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8K124

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000063677

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8K124, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8K124

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 120PHPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 411DisorderedSequence analysisAdd BLAST241

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili444 – 469Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi258 – 273Polar residuesSequence analysisAdd BLAST16
Compositional biasi281 – 298Polar residuesSequence analysisAdd BLAST18
Compositional biasi326 – 353Polar residuesSequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVFF, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026551_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8K124

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHWKDRY

Database of Orthologous Groups

More...
OrthoDBi
827145at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8K124

TreeFam database of animal gene trees

More...
TreeFami
TF333115

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043448, PKHO1/2

The PANTHER Classification System

More...
PANTHERi
PTHR15871, PTHR15871, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8K124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEESIKEGS EKPRGARTAD KAGWIKKSSG GLLGLWKDRY LLLCQAQLLV
60 70 80 90 100
YENEDEQKCV ETVELGSYEK CQDLRTLLKR KHHRFILLRS PGNKVSDIKF
110 120 130 140 150
QAPSGEEKES WIKALNEGIN RGKNKAFDEV KVDKTCALEH VTRNRVRGGQ
160 170 180 190 200
RRRPPTRIHL KEVASAASDG LSRLDLDVPD SGPPVFAPLS DISEDQPQEP
210 220 230 240 250
PRALMPPVKP SPGPETSAVE DSKETPAGER ALTPDSASSG ANPESQEDAE
260 270 280 290 300
TPAKEDSDVK SLPNSTLSEK LKVSWENPSP EKPSAPESAQ LSSSETPEAT
310 320 330 340 350
PRESKKPPAP PPKILSEKMK ACMSGVDASG SSQSSEAPET TSPEPTQVSV
360 370 380 390 400
NGMDDGPESA LQAMGIPGPA PEDAAASPAL PFSDLPSQFH PRSSSLGDLL
410 420 430 440 450
RESPQHPRLP KEKLYRAQLE VKVASKQTEK LLNQVLGSEP PPVCAESLLS
460 470 480 490
QAVEQLRQAT QVLQEMRDLG ELNQETPGLV QKRKELVTLY RRSAP
Length:495
Mass (Da):53,872
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2105D71A407498FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 4MEEE → VRRWRNWAEQDKTFP in BAE32369 (PubMed:16141072).Curated4
Sequence conflicti183P → A in BAE41823 (PubMed:16141072).Curated1
Sequence conflicti218A → P in BAE32369 (PubMed:16141072).Curated1
Sequence conflicti330 – 332GSS → TRP in AAH25598 (PubMed:15489334).Curated3
Sequence conflicti396 – 428LGDLL…ASKQT → HAGGVEWGWGLPRLSPCPYD PPFLSFGNKPHFM in BAC25735 (PubMed:16141072).CuratedAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK028069 mRNA Translation: BAC25735.1
AK154092 mRNA Translation: BAE32369.1
AK170479 mRNA Translation: BAE41823.1
BC025598 mRNA Translation: AAH25598.1
BC028908 mRNA Translation: AAH28908.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23294.1

NCBI Reference Sequences

More...
RefSeqi
NP_694759.1, NM_153119.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000068944; ENSMUSP00000063677; ENSMUSG00000050721

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102595

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:102595

UCSC genome browser

More...
UCSCi
uc009qdl.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028069 mRNA Translation: BAC25735.1
AK154092 mRNA Translation: BAE32369.1
AK170479 mRNA Translation: BAE41823.1
BC025598 mRNA Translation: AAH25598.1
BC028908 mRNA Translation: AAH28908.1
CCDSiCCDS23294.1
RefSeqiNP_694759.1, NM_153119.3

3D structure databases

SMRiQ8K124
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221902, 1 interactor
IntActiQ8K124, 1 interactor
MINTiQ8K124
STRINGi10090.ENSMUSP00000063677

PTM databases

iPTMnetiQ8K124
PhosphoSitePlusiQ8K124

Proteomic databases

EPDiQ8K124
jPOSTiQ8K124
MaxQBiQ8K124
PaxDbiQ8K124
PeptideAtlasiQ8K124
PRIDEiQ8K124
ProteomicsDBi289606

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
102595

Genome annotation databases

EnsembliENSMUST00000068944; ENSMUSP00000063677; ENSMUSG00000050721
GeneIDi102595
KEGGimmu:102595
UCSCiuc009qdl.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80301
MGIiMGI:2143132, Plekho2

Phylogenomic databases

eggNOGiENOG502QVFF, Eukaryota
GeneTreeiENSGT00530000063760
HOGENOMiCLU_026551_3_0_1
InParanoidiQ8K124
OMAiGHWKDRY
OrthoDBi827145at2759
PhylomeDBiQ8K124
TreeFamiTF333115

Enzyme and pathway databases

ReactomeiR-MMU-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
102595, 2 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plekho2, mouse

Protein Ontology

More...
PROi
PR:Q8K124
RNActiQ8K124, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050721, Expressed in granulocyte and 195 other tissues
GenevisibleiQ8K124, MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR043448, PKHO1/2
PANTHERiPTHR15871, PTHR15871, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHO2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K124
Secondary accession number(s): Q3TCY2
, Q3U4R2, Q8C1F2, Q8R140
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: June 2, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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