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Entry version 139 (07 Oct 2020)
Sequence version 2 (24 Mar 2009)
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Protein

Nuclear factor of activated T-cells, cytoplasmic 4

Gene

Nfatc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ca2+-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697). Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314). Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter (PubMed:17198697). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (PubMed:17198697).By similarity1 Publication5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi430 – 437By similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor of activated T-cells, cytoplasmic 4By similarity
Short name:
NF-ATc4By similarity
Short name:
NFATc41 Publication
Alternative name(s):
T-cell transcription factor NFAT31 Publication
Short name:
NF-AT31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nfatc4Imported
Synonyms:Nfat31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920431, Nfatc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype (PubMed:12370307). However, adult mutant animals show selective impairment in the formation of spatial long-term memory and long-term potentiation. They exhibit a reduced number of hippocampal adult-born neurons compared to wild-type littermates (PubMed:22586092). Simultaneous knockout of NFATC3 and NFATC4 results in embryonic death soon after 10.5 dpc. Embryos appear normal at 9.5 dpc. At 10.5 dpc, they exhibit defects in cardiac development, including dilated thin translucent hearts, pericardial effusion and anemia. Despite a mild generalized developmental delay, the heads, tails, and limb buds are well developed. By 11.5 dpc, mutant embryos are either necrotic or resorbed (PubMed:12750314).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003674331 – 901Nuclear factor of activated T-cells, cytoplasmic 4Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei168Phosphoserine; by MAPK7 and MAPK141 Publication1
Modified residuei170Phosphoserine; by MAPK7 and MAPK141 Publication1
Modified residuei213Phosphoserine; by MAPK8 and MAPK9By similarity1
Modified residuei217Phosphoserine; by MAPK8 and MAPK9By similarity1
Modified residuei289PhosphoserineCombined sources1
Modified residuei334Phosphoserine; by RPS6KA3By similarity1
Modified residuei344PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki689Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin/PPP3CA. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7/ERK5 and MAPK14/p38, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3 (PubMed:18691762). Phosphorylated by GSK3B (By similarity). Phosphorylation by GSK3B markedly increases NFATC4 ubiquitination (By similarity). Phosphorylation by MAPK8/JNK1, MAPK9/JNK2 and RPS6KA3 may stimulate NFATC4 transcriptional activity. Phosphorylation at Ser-168 and Ser-170 is stimulated by UV irradiation (By similarity).By similarity1 Publication
Ubiquitinated, leading to degradation by the proteasome. Ubiquitination may be stimulated by GSK3B-dependent phosphorylation. Polyubiquitin linkage mainly occurs through 'Lys-48'.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8K120

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8K120

PeptideAtlas

More...
PeptideAtlasi
Q8K120

PRoteomics IDEntifications database

More...
PRIDEi
Q8K120

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8K120

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8K120

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:18675896). In the brain, expressed in neurons (PubMed:18675896, PubMed:25663301). Expressed in the hippocampus (at protein level) (PubMed:25663301). In the hippocampus, expressed in both the CA1-CA3 pyramidal cells and the dentate gyrus granular cells (PubMed:22586092). Expressed in a subset of hippocampal cells representing adult-born neurons (at protein level) (PubMed:22586092). In the olfactory system, expressed at low levels in the glomerular and granular layers and in the mitral cell layer (PubMed:18675896). In the cerebellum, expressed at moderate levels in granular neurons (PubMed:18675896). Expressed at moderate levels in the choroid plexus and ependymal cells (PubMed:18675896). Expressed in neurons of the cochlear nucleus (at protein level) (PubMed:18354019). Expressed at low levels in the heart (at protein level) (PubMed:12370307).5 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels in the embryonic brain at 13.5 dpc (PubMed:18675896, PubMed:22586092). Expression decreases thereafter, reaching the lowest levels at postnatal day 14 and remaining unchanged in adulthood (PubMed:18675896). Expressed in the developing heart at 13.5 and 16.5 dpc, during the transition from spongy to compact myocardium (PubMed:17198697).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by BDNF.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023411, Expressed in lymph node and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8K120, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8K120, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other NFAT proteins, such as NFATC3, or members of the activating protein-1 (AP-1) family and MAF can also bind the complex. NFAT proteins can bind DNA as monomers or dimers (Probable).

Interacts with CREBBP; this interaction potentiates transcription activation (By similarity).

Interacts with MAPK8/JNK1 and MAPK9/JNK2 (By similarity).

Interacts with GATA4 (via the second Zn finger) (PubMed:9568714).

Interacts (via N-terminus) with IRAK1 (via C-terminus) (By similarity).

Interacts with RPS6KA3 (By similarity).

Interacts with HOMER1, HOMER2 and HOMER3; this interaction competes with calcineurin/PPP3CA-binding and hence prevents NFATC4 dephosphorylation and activation (By similarity).

Interacts with ESR1 and ESR2; this interaction decreases NFATC4 transcriptional activity (By similarity).

Interacts with MTOR and MAPK7/ERK5 (By similarity).

By similarity1 Publication1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
215821, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000024179

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q8K120, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8K120

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati213 – 229SP 1Sequence analysisAdd BLAST17
Repeati277 – 293SP 2; approximateSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini401 – 582RHDPROSITE-ProRule annotationAdd BLAST182
Domaini586 – 683IPT/TIGSequence analysisAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni114 – 119Calcineurin-bindingBy similarity6
Regioni213 – 2932 approximate SP repeatsSequence analysisAdd BLAST81

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi268 – 270Nuclear localization signalSequence analysis3
Motifi672 – 674Nuclear localization signalSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 327Pro-richSequence analysisAdd BLAST305
Compositional biasi692 – 836Pro-richSequence analysisAdd BLAST145

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Rel similarity domain (RSD) or Rel homology domain (RHD) allows DNA-binding and cooperative interactions with AP-1 factors.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RIHQ, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000160923

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_010185_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8K120

KEGG Orthology (KO)

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KOi
K17334

Identification of Orthologs from Complete Genome Data

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OMAi
SQRAGMH

Database of Orthologous Groups

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OrthoDBi
95502at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8K120

TreeFam database of animal gene trees

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TreeFami
TF326480

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
2.60.40.340, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR12533, PTHR12533, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01789, NUCFACTORATC

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00429, IPT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50254, REL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 14 Publications (identifier: Q8K120-1) [UniParc]FASTAAdd to basket
Also known as: I-IXL1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAASCEDEE LEFKLVFGEE KEPPPLGPGG PGEELDSEDT PPCCRLALGE
60 70 80 90 100
PLPYGAAPIG IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG
110 120 130 140 150
NAGGAGGGRV LECPSIRITS ISPTPDPPTS LEDTSETWGD GSPRDYPPPE
160 170 180 190 200
GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA LYAACDEVES
210 220 230 240 250
ELNEAASRFG LSSPLPSPRA SPRPWTPEDP WSLYGPSSGG RAPEDSWLLL
260 270 280 290 300
SAPGPVPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGPEPPPP
310 320 330 340 350
PPLPLVRDPS SPGPFDYVGA PPTESIPQKT RRTSSEQAVA LPRSEEPPSC
360 370 380 390 400
NGKLPSGTED SVAAPGALRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT
410 420 430 440 450
SALPPLDWPL PSQYEQLELR IEVQPRAHHR AHYETEGSRG AVKAAPGGHP
460 470 480 490 500
VVKLLGYSEK PLTLQMFIGT ADERSLRPHA FYQVHRITGK MVATASYEAV
510 520 530 540 550
VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV
560 570 580 590 600
RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVET YSPSACSVRG
610 620 630 640 650
GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEAAVNRLQ SSEVTLTLTI
660 670 680 690 700
PEYSNKRVSR PVQVYFYVSN GRRKRSPTQS FKFLPVVFKE EPLPDSSLRG
710 720 730 740 750
FPSTSGPPFG PDVDFSPPRP PYPSYPHEDP AYETPYLSEG FGYSTPALYP
760 770 780 790 800
QTGPPPSYRS GLRMFPETGG TTGCARLPSV SFLPRPFPGD QYGGQGSSFA
810 820 830 840 850
LGLPFSPPAP FRPPLPSSPP LEDPFHPQSA IHPLPPEGYN EVGPGYTPGE
860 870 880 890 900
GASEQEKARG GYSSGFRDSV PIQGITLEEV SEIIGRDLSG FPARPGEEPP

A
Length:901
Mass (Da):95,782
Last modified:March 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5977695F888F6538
GO
Isoform 21 Publication (identifier: Q8K120-2) [UniParc]FASTAAdd to basket
Also known as: I-IXi1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     880-894: VSEIIGRDLSGFPAR → GGCGTGGCECK
     895-901: Missing.

Show »
Length:890
Mass (Da):94,459
Checksum:i1083BBF9972F0742
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRR0A0A2I3BRR0_MOUSE
Nuclear factor of-activated T-cells...
Nfatc4
831Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRX2A0A2I3BRX2_MOUSE
Nuclear factor of-activated T-cells...
Nfatc4
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BS51A0A2I3BS51_MOUSE
Nuclear factor of-activated T-cells...
Nfatc4
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135S → P in AAH28928 (PubMed:15489334).Curated1
Sequence conflicti379 – 380AV → TM in AAG39446 (PubMed:11344309).Curated2
Sequence conflicti379 – 380AV → TM in AAF98174 (PubMed:11344309).Curated2
Sequence conflicti394 – 395HS → QT in AAG39446 (PubMed:11344309).Curated2
Sequence conflicti394 – 395HS → QT in AAF98174 (PubMed:11344309).Curated2
Sequence conflicti562G → S in AAH28928 (PubMed:15489334).Curated1
Sequence conflicti589 – 590ET → GD in AAG39446 (PubMed:11344309).Curated2
Sequence conflicti589 – 590ET → GD in AAF98174 (PubMed:11344309).Curated2
Sequence conflicti662V → I in AAG39446 (PubMed:11344309).Curated1
Sequence conflicti662V → I in AAF98174 (PubMed:11344309).Curated1
Sequence conflicti730P → L in AAG39446 (PubMed:11344309).Curated1
Sequence conflicti730P → L in AAF98174 (PubMed:11344309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053054880 – 894VSEII…GFPAR → GGCGTGGCECK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_053055895 – 901Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF283284 mRNA Translation: AAF98174.1
AF309389, AF309388 Genomic DNA Translation: AAG39446.1
EU887656 mRNA Translation: ACG55676.1
EU887657 mRNA Translation: ACG55677.1
AK159078 mRNA Translation: BAE34797.1
CH466535 Genomic DNA Translation: EDL36234.1
BC028928 mRNA Translation: AAH28928.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27132.1 [Q8K120-1]
CCDS49500.1 [Q8K120-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161818.1, NM_001168346.1 [Q8K120-2]
NP_076188.3, NM_023699.3 [Q8K120-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024179; ENSMUSP00000024179; ENSMUSG00000023411 [Q8K120-1]
ENSMUST00000172271; ENSMUSP00000132763; ENSMUSG00000023411 [Q8K120-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
73181

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:73181

UCSC genome browser

More...
UCSCi
uc007uax.2, mouse [Q8K120-1]
uc011zlq.1, mouse [Q8K120-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283284 mRNA Translation: AAF98174.1
AF309389, AF309388 Genomic DNA Translation: AAG39446.1
EU887656 mRNA Translation: ACG55676.1
EU887657 mRNA Translation: ACG55677.1
AK159078 mRNA Translation: BAE34797.1
CH466535 Genomic DNA Translation: EDL36234.1
BC028928 mRNA Translation: AAH28928.1
CCDSiCCDS27132.1 [Q8K120-1]
CCDS49500.1 [Q8K120-2]
RefSeqiNP_001161818.1, NM_001168346.1 [Q8K120-2]
NP_076188.3, NM_023699.3 [Q8K120-1]

3D structure databases

SMRiQ8K120
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215821, 2 interactors
STRINGi10090.ENSMUSP00000024179

PTM databases

iPTMnetiQ8K120
PhosphoSitePlusiQ8K120

Proteomic databases

jPOSTiQ8K120
PaxDbiQ8K120
PeptideAtlasiQ8K120
PRIDEiQ8K120

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
9248, 466 antibodies

Genome annotation databases

EnsembliENSMUST00000024179; ENSMUSP00000024179; ENSMUSG00000023411 [Q8K120-1]
ENSMUST00000172271; ENSMUSP00000132763; ENSMUSG00000023411 [Q8K120-2]
GeneIDi73181
KEGGimmu:73181
UCSCiuc007uax.2, mouse [Q8K120-1]
uc011zlq.1, mouse [Q8K120-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4776
MGIiMGI:1920431, Nfatc4

Phylogenomic databases

eggNOGiENOG502RIHQ, Eukaryota
GeneTreeiENSGT00940000160923
HOGENOMiCLU_010185_2_0_1
InParanoidiQ8K120
KOiK17334
OMAiSQRAGMH
OrthoDBi95502at2759
PhylomeDBiQ8K120
TreeFamiTF326480

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
73181, 2 hits in 18 CRISPR screens

Protein Ontology

More...
PROi
PR:Q8K120
RNActiQ8K120, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023411, Expressed in lymph node and 238 other tissues
ExpressionAtlasiQ8K120, baseline and differential
GenevisibleiQ8K120, MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
2.60.40.340, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR008366, NFAT
IPR008967, p53-like_TF_DNA-bd
IPR032397, RHD_dimer
IPR011539, RHD_DNA_bind_dom
IPR037059, RHD_DNA_bind_dom_sf
PANTHERiPTHR12533, PTHR12533, 1 hit
PfamiView protein in Pfam
PF16179, RHD_dimer, 1 hit
PF00554, RHD_DNA_bind, 1 hit
PRINTSiPR01789, NUCFACTORATC
SMARTiView protein in SMART
SM00429, IPT, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50254, REL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFAC4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8K120
Secondary accession number(s): B5B2X2, Q3TXW7, Q9EP91
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: October 7, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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