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Protein

Integrator complex subunit 9

Gene

Ints9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.By similarity

Miscellaneous

Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 9
Short name:
Int9
Gene namesi
Name:Ints9
Synonyms:D14Ertd231e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098533 Ints9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595591 – 658Integrator complex subunit 9Add BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8K114
PaxDbiQ8K114
PeptideAtlasiQ8K114
PRIDEiQ8K114

PTM databases

iPTMnetiQ8K114
PhosphoSitePlusiQ8K114

Expressioni

Gene expression databases

CleanExiMM_INTS9

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (PubMed:26206133).By similarity1 Publication

Protein-protein interaction databases

BioGridi229188, 1 interactor
IntActiQ8K114, 1 interactor
MINTiQ8K114
STRINGi10090.ENSMUSP00000045552

Structurei

3D structure databases

ProteinModelPortaliQ8K114
SMRiQ8K114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1138 Eukaryota
COG1236 LUCA
HOGENOMiHOG000045359
HOVERGENiHBG081802
InParanoidiQ8K114
KOiK13146
PhylomeDBiQ8K114
TreeFamiTF314100

Family and domain databases

InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR027074 Integrator_9su
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR11203:SF2 PTHR11203:SF2, 1 hit
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS
60 70 80 90 100
NLPGWSLKDG NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL
110 120 130 140 150
ISNYHCMMAL PYITEHTGFT GTVYATEPTM QIGRLLMEEL VNFIERVPKA
160 170 180 190 200
QSASLWKNKD IQRLLPSPLK DAVEVSTWRR CYTMQEVNSA LSKIQLVGYS
210 220 230 240 250
QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS SLLTTHPQPM
260 270 280 290 300
DQASLKNSDV LILTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY
310 320 330 340 350
PSGVIYDLLE CLYQYIDSAG LSNIPFYFIS PVANSSLEFS QIFAEWLCHN
360 370 380 390 400
KQSKVYLPEP PFPHAELIQT NKLKHYRSIH GDFSNDFRQP CVLFTGHPSL
410 420 430 440 450
RFGDVVHFME LWGKSSLNTI IFTEPDFSYL EALAPYQPLA MKCIYCPIDT
460 470 480 490 500
RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP AQAHRMDLMI DCQPPAMSYR
510 520 530 540 550
RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV SAVLHTKDNK
560 570 580 590 600
HVLQPPPKPT QPTSSKKRKR VNEDIPDCKV LKPLLSGSIP VEQFVQTLEK
610 620 630 640 650
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND ETLRVRLRDL

VLRFLQKF
Length:658
Mass (Da):74,078
Last modified:October 1, 2002 - v1
Checksum:i617C25FA07B60F92
GO
Isoform 2 (identifier: Q8K114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     522-576: LADSLVPMEI...KRKRVNEDIP → VSCCPFTLKS...FTGMALQVTS
     577-658: Missing.

Note: No experimental confirmation available.
Show »
Length:576
Mass (Da):64,721
Checksum:iC0B2C91DB5D43795
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0J5A0A0R4J0J5_MOUSE
Integrator complex subunit 9
Ints9
687Annotation score:

Sequence cautioni

The sequence BAC36917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021470522 – 576LADSL…NEDIP → VSCCPFTLKSLLSTRVHSGH CQSLKTEGRKEHRPPGKLCY VPYVAFTGMALQVTS in isoform 2. CuratedAdd BLAST55
Alternative sequenceiVSP_021471577 – 658Missing in isoform 2. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038979 mRNA Translation: BAC30191.1
AK077634 mRNA Translation: BAC36917.1 Different initiation.
AK136992 mRNA Translation: BAE23199.1
AK150195 mRNA Translation: BAE29371.1
BC028953 mRNA Translation: AAH28953.1
BC055700 mRNA Translation: AAH55700.1
RefSeqiNP_001240660.1, NM_001253731.1
NP_700463.2, NM_153414.4
UniGeneiMm.71332

Genome annotation databases

GeneIDi210925
KEGGimmu:210925
UCSCiuc007uiv.1 mouse [Q8K114-2]
uc007uiw.2 mouse [Q8K114-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038979 mRNA Translation: BAC30191.1
AK077634 mRNA Translation: BAC36917.1 Different initiation.
AK136992 mRNA Translation: BAE23199.1
AK150195 mRNA Translation: BAE29371.1
BC028953 mRNA Translation: AAH28953.1
BC055700 mRNA Translation: AAH55700.1
RefSeqiNP_001240660.1, NM_001253731.1
NP_700463.2, NM_153414.4
UniGeneiMm.71332

3D structure databases

ProteinModelPortaliQ8K114
SMRiQ8K114
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229188, 1 interactor
IntActiQ8K114, 1 interactor
MINTiQ8K114
STRINGi10090.ENSMUSP00000045552

PTM databases

iPTMnetiQ8K114
PhosphoSitePlusiQ8K114

Proteomic databases

EPDiQ8K114
PaxDbiQ8K114
PeptideAtlasiQ8K114
PRIDEiQ8K114

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi210925
KEGGimmu:210925
UCSCiuc007uiv.1 mouse [Q8K114-2]
uc007uiw.2 mouse [Q8K114-1]

Organism-specific databases

CTDi55756
MGIiMGI:1098533 Ints9

Phylogenomic databases

eggNOGiKOG1138 Eukaryota
COG1236 LUCA
HOGENOMiHOG000045359
HOVERGENiHBG081802
InParanoidiQ8K114
KOiK13146
PhylomeDBiQ8K114
TreeFamiTF314100

Miscellaneous databases

PROiPR:Q8K114
SOURCEiSearch...

Gene expression databases

CleanExiMM_INTS9

Family and domain databases

InterProiView protein in InterPro
IPR022712 Beta_Casp
IPR027074 Integrator_9su
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR11203:SF2 PTHR11203:SF2, 1 hit
PfamiView protein in Pfam
PF10996 Beta-Casp, 1 hit
PF16661 Lactamase_B_6, 1 hit
SMARTiView protein in SMART
SM01027 Beta-Casp, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINT9_MOUSE
AccessioniPrimary (citable) accession number: Q8K114
Secondary accession number(s): Q8BP62, Q8CAE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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