Translational activator of cytochrome c oxidase 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• mitochondrial ribosome binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]
• mRNA binding Source: MGIInferred from direct assayⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]
• rRNA binding Source: MGIInferred from direct assayⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• mitochondrial cytochrome c oxidase assembly Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]
• motor learning Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of cytochrome-c oxidase activity Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of mitochondrial translation Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice."
    Richman T.R., Spahr H., Ermer J.A., Davies S.M., Viola H.M., Bates K.A., Papadimitriou J., Hool L.C., Rodger J., Larsson N.G., Rackham O., Filipovska A.
    Nat Commun 7:11884-11884(2016) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS 
        60         70         80         90        100
ATASAGHNKW SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS 
       110        120        130        140        150
SLANILELCR SKNMPKSTIE SALKTEKNKG IYLLYEGRGP GGSSLLIEAL 
       160        170        180        190        200
SNSGPKCHLD IKYILNKNGG MMAEGARHFF DKKGVVVVGV EDREKKAVNL 
       210        220        230        240        250
ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR KKLDSLGLCP 
       260        270        280        290 
VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families