UniProtKB - Q8K0Z7 (TACO1_MOUSE)
Protein
Translational activator of cytochrome c oxidase 1
Gene
Taco1
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.By similarity
GO - Molecular functioni
- mitochondrial ribosome binding Source: MGI
- mRNA binding Source: MGI
- rRNA binding Source: MGI
GO - Biological processi
- mitochondrial cytochrome c oxidase assembly Source: MGI
- motor learning Source: MGI
- regulation of cytochrome-c oxidase activity Source: MGI
- regulation of mitochondrial translation Source: MGI
Keywordsi
Molecular function | Activator |
Biological process | Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Translational activator of cytochrome c oxidase 1Alternative name(s): Coiled-coil domain-containing protein 44 Translational activator of mitochondrially-encoded cytochrome c oxidase 1 |
Gene namesi | Name:Taco1 Synonyms:Ccdc44 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1917457, Taco1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000175943 | 1 – 294 | Translational activator of cytochrome c oxidase 1Add BLAST | 294 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 162 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8K0Z7 |
jPOSTi | Q8K0Z7 |
MaxQBi | Q8K0Z7 |
PaxDbi | Q8K0Z7 |
PeptideAtlasi | Q8K0Z7 |
PRIDEi | Q8K0Z7 |
PTM databases
iPTMneti | Q8K0Z7 |
PhosphoSitePlusi | Q8K0Z7 |
SwissPalmi | Q8K0Z7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001983, Expressed in liver and 82 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 213915, 3 interactors |
IntActi | Q8K0Z7, 1 interactor |
MINTi | Q8K0Z7 |
STRINGi | 10090.ENSMUSP00000002048 |
Miscellaneous databases
RNActi | Q8K0Z7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8K0Z7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 190 – 224 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Belongs to the TACO1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2972, Eukaryota |
GeneTreei | ENSGT00390000012820 |
HOGENOMi | CLU_062974_3_0_1 |
InParanoidi | Q8K0Z7 |
OMAi | ETIMYEG |
OrthoDBi | 1199273at2759 |
PhylomeDBi | Q8K0Z7 |
TreeFami | TF300070 |
Family and domain databases
Gene3Di | 1.10.10.200, 1 hit 3.30.70.980, 2 hits |
InterProi | View protein in InterPro IPR017856, Integrase-like_N IPR002876, Transcrip_reg_TACO1-like IPR026564, Transcrip_reg_TACO1-like_dom3 IPR029072, YebC-like |
PANTHERi | PTHR12532, PTHR12532, 1 hit |
Pfami | View protein in Pfam PF01709, Transcrip_reg, 1 hit |
SUPFAMi | SSF75625, SSF75625, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8K0Z7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSWAAASLR MTAVPCFRVR CLGFRVGPWG ASQHANPGCG AAPHRTLHVS
60 70 80 90 100
ATASAGHNKW SKVRHIKGPK DMERSRIFSK LTLSIRLAVK EGGPNPENNS
110 120 130 140 150
SLANILELCR SKNMPKSTIE SALKTEKNKG IYLLYEGRGP GGSSLLIEAL
160 170 180 190 200
SNSGPKCHLD IKYILNKNGG MMAEGARHFF DKKGVVVVGV EDREKKAVNL
210 220 230 240 250
ERALELAIEA GAEDVKEAED EEEKNLFKFI CDASSLHQVR KKLDSLGLCP
260 270 280 290
VSCSMEFIPH SKVQLAEPEL EQAAHLIQAL NNYEDVIHVY DNIE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | R → G in BAE39960 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010072 mRNA Translation: BAB26682.1 AK047078 mRNA Translation: BAC32953.1 AK140143 mRNA Translation: BAE24253.1 AK167963 mRNA Translation: BAE39960.1 AL596331 Genomic DNA No translation available. BC029182 mRNA Translation: AAH29182.1 |
CCDSi | CCDS25547.1 |
RefSeqi | NP_081622.1, NM_027346.1 |
Genome annotation databases
Ensembli | ENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983 |
GeneIDi | 70207 |
KEGGi | mmu:70207 |
UCSCi | uc007lyb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK010072 mRNA Translation: BAB26682.1 AK047078 mRNA Translation: BAC32953.1 AK140143 mRNA Translation: BAE24253.1 AK167963 mRNA Translation: BAE39960.1 AL596331 Genomic DNA No translation available. BC029182 mRNA Translation: AAH29182.1 |
CCDSi | CCDS25547.1 |
RefSeqi | NP_081622.1, NM_027346.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5EKZ | X-ray | 2.00 | A | 1-294 | [»] | |
SMRi | Q8K0Z7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 213915, 3 interactors |
IntActi | Q8K0Z7, 1 interactor |
MINTi | Q8K0Z7 |
STRINGi | 10090.ENSMUSP00000002048 |
PTM databases
iPTMneti | Q8K0Z7 |
PhosphoSitePlusi | Q8K0Z7 |
SwissPalmi | Q8K0Z7 |
Proteomic databases
EPDi | Q8K0Z7 |
jPOSTi | Q8K0Z7 |
MaxQBi | Q8K0Z7 |
PaxDbi | Q8K0Z7 |
PeptideAtlasi | Q8K0Z7 |
PRIDEi | Q8K0Z7 |
Protocols and materials databases
Antibodypediai | 18674, 173 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000002048; ENSMUSP00000002048; ENSMUSG00000001983 |
GeneIDi | 70207 |
KEGGi | mmu:70207 |
UCSCi | uc007lyb.1, mouse |
Organism-specific databases
CTDi | 51204 |
MGIi | MGI:1917457, Taco1 |
Phylogenomic databases
eggNOGi | KOG2972, Eukaryota |
GeneTreei | ENSGT00390000012820 |
HOGENOMi | CLU_062974_3_0_1 |
InParanoidi | Q8K0Z7 |
OMAi | ETIMYEG |
OrthoDBi | 1199273at2759 |
PhylomeDBi | Q8K0Z7 |
TreeFami | TF300070 |
Miscellaneous databases
BioGRID-ORCSi | 70207, 4 hits in 17 CRISPR screens |
PROi | PR:Q8K0Z7 |
RNActi | Q8K0Z7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001983, Expressed in liver and 82 other tissues |
Family and domain databases
Gene3Di | 1.10.10.200, 1 hit 3.30.70.980, 2 hits |
InterProi | View protein in InterPro IPR017856, Integrase-like_N IPR002876, Transcrip_reg_TACO1-like IPR026564, Transcrip_reg_TACO1-like_dom3 IPR029072, YebC-like |
PANTHERi | PTHR12532, PTHR12532, 1 hit |
Pfami | View protein in Pfam PF01709, Transcrip_reg, 1 hit |
SUPFAMi | SSF75625, SSF75625, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TACO1_MOUSE | |
Accessioni | Q8K0Z7Primary (citable) accession number: Q8K0Z7 Secondary accession number(s): B1AR86 Q9CV09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 4, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families