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Protein

Fasciculation and elongation protein zeta-1

Gene

Fez1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).By similarity

GO - Molecular functioni

  • gamma-tubulin binding Source: MGI
  • protein kinase C binding Source: MGI
  • protein N-terminus binding Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-1
Alternative name(s):
Zygin I
Zygin-1
Gene namesi
Name:Fez1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2670976 Fez1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895261 – 392Fasciculation and elongation protein zeta-1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Modified residuei298PhosphoserineBy similarity1
Modified residuei316PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination.By similarity
Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8K0X8
PaxDbiQ8K0X8
PeptideAtlasiQ8K0X8
PRIDEiQ8K0X8

PTM databases

iPTMnetiQ8K0X8
PhosphoSitePlusiQ8K0X8

Expressioni

Gene expression databases

BgeeiENSMUSG00000032118 Expressed in 225 organ(s), highest expression level in ventral horn of spinal cord
ExpressionAtlasiQ8K0X8 baseline and differential
GenevisibleiQ8K0X8 MM

Interactioni

Subunit structurei

Homodimer. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon. Interacts with UBE4B and SAP30L (By similarity). Interacts with SCOC and ULK1; SCOC interferes with ULK1-binding to FEZ1 (By similarity). Directly interacts with SCOC and UVRAG. Stabilizes the interaction between SCOC and UVRAG during amino acid starvation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231627, 4 interactors
STRINGi10090.ENSMUSP00000034630

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili230 – 298Sequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi95 – 98Poly-Glu4

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3919 Eukaryota
ENOG410Z11E LUCA
GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ8K0X8
OMAiEMMSFKS
OrthoDBiEOG091G0AC6
TreeFamiTF313128

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015642 FEZ_1
PANTHERiPTHR12394 PTHR12394, 1 hit
PTHR12394:SF4 PTHR12394:SF4, 1 hit
PfamiView protein in Pfam
PF07763 FEZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q8K0X8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAPLVSLDE EFEDIRPSCT EEPEEKPQCL YGTSPHHLED PSLSELENFS
60 70 80 90 100
SEIISFKSME DLVNEFDEKL NVCFRNYNAK TESLAPVKNQ LQIQEEEETL
110 120 130 140 150
RDEEVWDALT DNYIPSLSED WRDPNIEALN GNSSDIEIHE KEEEEFNEKS
160 170 180 190 200
ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGEISSQA
210 220 230 240 250
DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDRVE GAIRDFSEEL
260 270 280 290 300
VHQLARRDEL EFEKEVKNSF ITVLIEVQNK QREQRELMKK RRKEKGLSLQ
310 320 330 340 350
SNRIEKGSQM PLKRFSMEGI SNILQSGIRQ TFGSSGADRQ YLNTVIPYEK
360 370 380 390
KSSPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
Length:392
Mass (Da):45,215
Last modified:July 27, 2011 - v2
Checksum:i58907843A8D24B25
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXY1E0CXY1_MOUSE
Fasciculation and elongation protei...
Fez1
123Annotation score:
E0CYY9E0CYY9_MOUSE
Fasciculation and elongation protei...
Fez1
167Annotation score:
F6SG45F6SG45_MOUSE
Fasciculation and elongation protei...
Fez1
91Annotation score:
F6TRI8F6TRI8_MOUSE
Fasciculation and elongation protei...
Fez1
47Annotation score:
F7BWM9F7BWM9_MOUSE
Fasciculation and elongation protei...
Fez1
53Annotation score:
A0A1L1SSG8A0A1L1SSG8_MOUSE
Fasciculation and elongation protei...
Fez1
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → I in AAH29629 (PubMed:15489334).Curated1
Sequence conflicti171I → T in AAH29629 (PubMed:15489334).Curated1
Sequence conflicti217N → D in AAH29629 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141674 mRNA Translation: AAZ74351.1
BC029629 mRNA Translation: AAH29629.1
CCDSiCCDS40581.1
RefSeqiNP_898994.2, NM_183171.4
XP_006510290.1, XM_006510227.3
XP_006510291.1, XM_006510228.3
XP_006510292.1, XM_006510229.3
XP_017168801.1, XM_017313312.1
XP_017168802.1, XM_017313313.1
UniGeneiMm.5264

Genome annotation databases

EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118
GeneIDi235180
KEGGimmu:235180
UCSCiuc009ouc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ141674 mRNA Translation: AAZ74351.1
BC029629 mRNA Translation: AAH29629.1
CCDSiCCDS40581.1
RefSeqiNP_898994.2, NM_183171.4
XP_006510290.1, XM_006510227.3
XP_006510291.1, XM_006510228.3
XP_006510292.1, XM_006510229.3
XP_017168801.1, XM_017313312.1
XP_017168802.1, XM_017313313.1
UniGeneiMm.5264

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231627, 4 interactors
STRINGi10090.ENSMUSP00000034630

PTM databases

iPTMnetiQ8K0X8
PhosphoSitePlusiQ8K0X8

Proteomic databases

MaxQBiQ8K0X8
PaxDbiQ8K0X8
PeptideAtlasiQ8K0X8
PRIDEiQ8K0X8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034630; ENSMUSP00000034630; ENSMUSG00000032118
ENSMUST00000163816; ENSMUSP00000126072; ENSMUSG00000032118
GeneIDi235180
KEGGimmu:235180
UCSCiuc009ouc.1 mouse

Organism-specific databases

CTDi9638
MGIiMGI:2670976 Fez1

Phylogenomic databases

eggNOGiKOG3919 Eukaryota
ENOG410Z11E LUCA
GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ8K0X8
OMAiEMMSFKS
OrthoDBiEOG091G0AC6
TreeFamiTF313128

Miscellaneous databases

PROiPR:Q8K0X8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032118 Expressed in 225 organ(s), highest expression level in ventral horn of spinal cord
ExpressionAtlasiQ8K0X8 baseline and differential
GenevisibleiQ8K0X8 MM

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015642 FEZ_1
PANTHERiPTHR12394 PTHR12394, 1 hit
PTHR12394:SF4 PTHR12394:SF4, 1 hit
PfamiView protein in Pfam
PF07763 FEZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFEZ1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0X8
Secondary accession number(s): Q3YE74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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