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Protein

DPH3 homolog

Gene

Dph3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2.
Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5 (By similarity).By similarity

Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5358493 Synthesis of diphthamide-EEF2
UniPathwayi
UPA00559

Names & Taxonomyi

Protein namesi
Recommended name:
DPH3 homolog
Alternative name(s):
CSL-type zinc finger-containing protein 2
DelGEF-interacting protein 1
Short name:
DelGIP1
Gene namesi
Name:Dph3
Synonyms:Desr1, Zcsl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1922658 Dph3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal about 11.5 days after fertilization.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826211 – 82DPH3 homologAdd BLAST82

Proteomic databases

MaxQBiQ8K0W9
PaxDbiQ8K0W9
PRIDEiQ8K0W9

PTM databases

iPTMnetiQ8K0W9
PhosphoSitePlusiQ8K0W9

Expressioni

Tissue specificityi

Widely expressed with highest levels in heart, liver, kidney and testis.1 Publication

Developmental stagei

In the embryo, expressed during all stages of development.1 Publication

Gene expression databases

BgeeiENSMUSG00000021905 Expressed in 246 organ(s), highest expression level in quadriceps femoris
CleanExiMM_DPH3
ExpressionAtlasiQ8K0W9 baseline and differential
GenevisibleiQ8K0W9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022461

Structurei

Secondary structure

182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8K0W9
SMRiQ8K0W9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K0W9

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2923 Eukaryota
COG5216 LUCA
GeneTreeiENSGT00390000007225
HOGENOMiHOG000190740
HOVERGENiHBG056007
InParanoidiQ8K0W9
KOiK15455
OMAiYSYPCPC
OrthoDBiEOG091G16WK
PhylomeDBiQ8K0W9
TreeFamiTF315102

Family and domain databases

Gene3Di3.10.660.10, 1 hit
InterProiView protein in InterPro
IPR007872 Znf_DHP
IPR036671 Znf_DHP_sf
PfamiView protein in Pfam
PF05207 zf-CSL, 1 hit
SUPFAMiSSF144217 SSF144217, 1 hit
PROSITEiView protein in PROSITE
PS51074 ZF_DPH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K0W9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVFHDEVEI EDFQYDEDSE TYFYPCPCGD NFAITKEDLE NGEDVATCPS
60 70 80
CSLIIKVIYD KDQFMCGETV PAPSTNKELV KC
Length:82
Mass (Da):9,286
Last modified:October 1, 2002 - v1
Checksum:i3BC612EFE72E7670
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXV3D3YXV3_MOUSE
DPH3 homolog
Dph3
57Annotation score:
E9PZC5E9PZC5_MOUSE
DPH3 homolog
Dph3
54Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048097 mRNA Translation: BAC33240.1
AK011448 mRNA Translation: BAC25335.1
BC029910 mRNA Translation: AAH29910.1
BC039954 mRNA Translation: AAH39954.1
CCDSiCCDS36861.1
RefSeqiNP_001040898.1, NM_001047433.2
NP_001271275.1, NM_001284346.1
NP_758458.1, NM_172254.4
UniGeneiMm.2519

Genome annotation databases

EnsembliENSMUST00000022461; ENSMUSP00000022461; ENSMUSG00000021905
ENSMUST00000067955; ENSMUSP00000068491; ENSMUSG00000021905
GeneIDi105638
KEGGimmu:105638
UCSCiuc007syc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048097 mRNA Translation: BAC33240.1
AK011448 mRNA Translation: BAC25335.1
BC029910 mRNA Translation: AAH29910.1
BC039954 mRNA Translation: AAH39954.1
CCDSiCCDS36861.1
RefSeqiNP_001040898.1, NM_001047433.2
NP_001271275.1, NM_001284346.1
NP_758458.1, NM_172254.4
UniGeneiMm.2519

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGENMR-A1-70[»]
ProteinModelPortaliQ8K0W9
SMRiQ8K0W9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022461

PTM databases

iPTMnetiQ8K0W9
PhosphoSitePlusiQ8K0W9

Proteomic databases

MaxQBiQ8K0W9
PaxDbiQ8K0W9
PRIDEiQ8K0W9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022461; ENSMUSP00000022461; ENSMUSG00000021905
ENSMUST00000067955; ENSMUSP00000068491; ENSMUSG00000021905
GeneIDi105638
KEGGimmu:105638
UCSCiuc007syc.2 mouse

Organism-specific databases

CTDi285381
MGIiMGI:1922658 Dph3

Phylogenomic databases

eggNOGiKOG2923 Eukaryota
COG5216 LUCA
GeneTreeiENSGT00390000007225
HOGENOMiHOG000190740
HOVERGENiHBG056007
InParanoidiQ8K0W9
KOiK15455
OMAiYSYPCPC
OrthoDBiEOG091G16WK
PhylomeDBiQ8K0W9
TreeFamiTF315102

Enzyme and pathway databases

UniPathwayi
UPA00559

ReactomeiR-MMU-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

ChiTaRSiDph3 mouse
EvolutionaryTraceiQ8K0W9
PROiPR:Q8K0W9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021905 Expressed in 246 organ(s), highest expression level in quadriceps femoris
CleanExiMM_DPH3
ExpressionAtlasiQ8K0W9 baseline and differential
GenevisibleiQ8K0W9 MM

Family and domain databases

Gene3Di3.10.660.10, 1 hit
InterProiView protein in InterPro
IPR007872 Znf_DHP
IPR036671 Znf_DHP_sf
PfamiView protein in Pfam
PF05207 zf-CSL, 1 hit
SUPFAMiSSF144217 SSF144217, 1 hit
PROSITEiView protein in PROSITE
PS51074 ZF_DPH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPH3_MOUSE
AccessioniPrimary (citable) accession number: Q8K0W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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