Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phytanoyl-CoA hydroxylase-interacting protein

Gene

Phyhip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Its interaction with PHYH suggests a role in the development of the central system.

Miscellaneous

Overexpression in heart induce atrial tachycardia and increased susceptibility to aconitine-induced arrhythmia, possibly due to altered expression of voltage-gated K1+ channel and adrenergic beta1-receptor (ADRB1).

Names & Taxonomyi

Protein namesi
Recommended name:
Phytanoyl-CoA hydroxylase-interacting protein
Alternative name(s):
Phytanoyl-CoA hydroxylase-associated protein 1
Short name:
PAHX-AP1
Short name:
PAHXAP1
Gene namesi
Name:Phyhip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1860417 Phyhip

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584171 – 330Phytanoyl-CoA hydroxylase-interacting proteinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineCurated1
Glycosylationi325N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K0S0
PaxDbiQ8K0S0
PRIDEiQ8K0S0

PTM databases

iPTMnetiQ8K0S0
PhosphoSitePlusiQ8K0S0

Expressioni

Tissue specificityi

Highly expressed in the brain.1 Publication

Developmental stagei

At 18 dpc, expressed in most tissues, particularly in the skin. By neonatal day 1, the expression in brain and skin is markedly increased, whereas expression in the heart and skeletal muscles shows steady state levels similar to those observed in the fetus. At adulthood, very high expression in brain, little or no expression in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000003469 Expressed in 115 organ(s), highest expression level in cerebellum
CleanExiMM_PHYHIP
ExpressionAtlasiQ8K0S0 baseline and differential
GenevisibleiQ8K0S0 MM

Interactioni

Subunit structurei

Interacts with PHYH and ADGRB1.2 Publications

Protein-protein interaction databases

BioGridi222893, 1 interactor
IntActiQ8K0S0, 2 interactors
MINTiQ8K0S0
STRINGi10090.ENSMUSP00000003561

Structurei

3D structure databases

ProteinModelPortaliQ8K0S0
SMRiQ8K0S0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 115Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Belongs to the PHYHIP family.Curated

Phylogenomic databases

eggNOGiENOG410IEM3 Eukaryota
ENOG410Y0U7 LUCA
GeneTreeiENSGT00390000014563
HOGENOMiHOG000116361
HOVERGENiHBG053596
InParanoidiQ8K0S0
OMAiGRTHCGN
OrthoDBiEOG091G15WA
PhylomeDBiQ8K0S0
TreeFamiTF314485

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K0S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLSTPHSI EINNITCDSF RISWAMEDSD LERVTHYFID LNKKENKNSN
60 70 80 90 100
KFKHRDVPTK LVAKAVPLPM TVRGHWFLSP RTEYSVAVQT AVKQSDGEYL
110 120 130 140 150
VSGWSETVEF CTGDYAKEHL AQLQEKAEQI AGRMLRFSVF YRNHHKEYFQ
160 170 180 190 200
HARTHCGNVL QPYLKDNSGS HGSPTSGMLH GVFFSCNTEF NTGQPPQDSP
210 220 230 240 250
YGRWRFQIPA QRLFNPSTNL YFADFYCMYT AYHYAILVLA PKGSLGDRFC
260 270 280 290 300
RDRLPLLDIA CNKFLTCSVE DGELIFRHAQ DLILEIIYTE PVDLSLGTLG
310 320 330
EISGHQLMSL STADAKKDPS CKTCNISVGR
Length:330
Mass (Da):37,555
Last modified:October 1, 2002 - v1
Checksum:iC87196F5D6BDA7AD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXJ1E0CXJ1_MOUSE
Phytanoyl-CoA hydroxylase-interacti...
Phyhip
88Annotation score:

Sequence cautioni

The sequence AAH30494 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049900 mRNA Translation: BAC33979.1
BC030494 mRNA Translation: AAH30494.2 Different initiation.
CCDSiCCDS36971.1
RefSeqiNP_666093.1, NM_145981.3
XP_006518442.1, XM_006518379.3
XP_006518443.1, XM_006518380.3
UniGeneiMm.192598

Genome annotation databases

EnsembliENSMUST00000003561; ENSMUSP00000003561; ENSMUSG00000003469
GeneIDi105653
KEGGimmu:105653
UCSCiuc007uoa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049900 mRNA Translation: BAC33979.1
BC030494 mRNA Translation: AAH30494.2 Different initiation.
CCDSiCCDS36971.1
RefSeqiNP_666093.1, NM_145981.3
XP_006518442.1, XM_006518379.3
XP_006518443.1, XM_006518380.3
UniGeneiMm.192598

3D structure databases

ProteinModelPortaliQ8K0S0
SMRiQ8K0S0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222893, 1 interactor
IntActiQ8K0S0, 2 interactors
MINTiQ8K0S0
STRINGi10090.ENSMUSP00000003561

PTM databases

iPTMnetiQ8K0S0
PhosphoSitePlusiQ8K0S0

Proteomic databases

MaxQBiQ8K0S0
PaxDbiQ8K0S0
PRIDEiQ8K0S0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003561; ENSMUSP00000003561; ENSMUSG00000003469
GeneIDi105653
KEGGimmu:105653
UCSCiuc007uoa.1 mouse

Organism-specific databases

CTDi9796
MGIiMGI:1860417 Phyhip

Phylogenomic databases

eggNOGiENOG410IEM3 Eukaryota
ENOG410Y0U7 LUCA
GeneTreeiENSGT00390000014563
HOGENOMiHOG000116361
HOVERGENiHBG053596
InParanoidiQ8K0S0
OMAiGRTHCGN
OrthoDBiEOG091G15WA
PhylomeDBiQ8K0S0
TreeFamiTF314485

Miscellaneous databases

PROiPR:Q8K0S0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003469 Expressed in 115 organ(s), highest expression level in cerebellum
CleanExiMM_PHYHIP
ExpressionAtlasiQ8K0S0 baseline and differential
GenevisibleiQ8K0S0 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHYIP_MOUSE
AccessioniPrimary (citable) accession number: Q8K0S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again