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Protein

Zinc finger and BTB domain-containing protein 20

Gene

Zbtb20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (PubMed:27446912).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri578 – 600C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri715 – 737C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 20
Alternative name(s):
BTB/POZ domain zinc finger factor HOF
Zinc finger protein 288
Gene namesi
Name:Zbtb20
Synonyms:Zfp288
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1929213 Zbtb20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259611 – 741Zinc finger and BTB domain-containing protein 20Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei211PhosphothreonineBy similarity1
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphothreonineCombined sources1
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei690PhosphothreonineCombined sources1
Modified residuei695PhosphothreonineCombined sources1
Cross-linki723Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated with SUMO1.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8K0L9
PeptideAtlasiQ8K0L9
PRIDEiQ8K0L9

PTM databases

iPTMnetiQ8K0L9
PhosphoSitePlusiQ8K0L9

Expressioni

Tissue specificityi

Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia (PubMed:11744704). Expressed in adult and aged myogenic satellite cells (PubMed:27446912).2 Publications

Developmental stagei

Not expressed during development, is induced during establishment of satellite cells and acquisition of quiescence.1 Publication

Gene expression databases

BgeeiENSMUSG00000022708 Expressed in 301 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ZBTB20
ExpressionAtlasiQ8K0L9 baseline and differential
GenevisibleiQ8K0L9 MM

Interactioni

Subunit structurei

Can homodimerize. Binds to DNA.

Protein-protein interaction databases

IntActiQ8K0L9, 1 interactor
STRINGi10090.ENSMUSP00000078410

Structurei

3D structure databases

ProteinModelPortaliQ8K0L9
SMRiQ8K0L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 167BTBPROSITE-ProRule annotationAdd BLAST64

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri578 – 600C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri715 – 737C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ8K0L9
KOiK10501
OMAiESTHCRK
OrthoDBiEOG091G02AP
PhylomeDBiQ8K0L9
TreeFamiTF335684

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K0L9-1) [UniParc]FASTAAdd to basket
Also known as: HOF-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH
60 70 80 90 100
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR
110 120 130 140 150
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS
160 170 180 190 200
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV
210 220 230 240 250
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC
260 270 280 290 300
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
310 320 330 340 350
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER
360 370 380 390 400
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR
410 420 430 440 450
DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN
460 470 480 490 500
SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI
510 520 530 540 550
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF
560 570 580 590 600
TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH
610 620 630 640 650
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN
660 670 680 690 700
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR
710 720 730 740
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
Length:741
Mass (Da):81,034
Last modified:October 1, 2002 - v1
Checksum:i04C0744D66BFE418
GO
Isoform 2 (identifier: Q8K0L9-2) [UniParc]FASTAAdd to basket
Also known as: HOF-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:668
Mass (Da):73,382
Checksum:i5A6FF5BEEA3963A3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXK1E0CXK1_MOUSE
Zinc finger and BTB domain-containi...
Zbtb20
75Annotation score:
E0CYJ9E0CYJ9_MOUSE
Zinc finger and BTB domain-containi...
Zbtb20
131Annotation score:
E0CYH3E0CYH3_MOUSE
Zinc finger and BTB domain-containi...
Zbtb20
138Annotation score:
E0CXT9E0CXT9_MOUSE
Zinc finger and BTB domain-containi...
Zbtb20
60Annotation score:
E0CX28E0CX28_MOUSE
Zinc finger and BTB domain-containi...
Zbtb20
63Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88N → D in BAB23755 (PubMed:16141072).Curated1
Sequence conflicti421A → D in AAF06015 (PubMed:11744704).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0325041 – 73Missing in isoform 2. 2 PublicationsAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194030 mRNA Translation: AAF06015.1
AK005028 mRNA Translation: BAB23755.1
CT010512 Genomic DNA No translation available.
BC031114 mRNA Translation: AAH31114.1
BC056446 mRNA Translation: AAH56446.1
CCDSiCCDS28178.1 [Q8K0L9-1]
CCDS49851.1 [Q8K0L9-2]
RefSeqiNP_001272734.1, NM_001285805.1 [Q8K0L9-1]
NP_062752.2, NM_019778.2 [Q8K0L9-1]
NP_851401.1, NM_181058.1 [Q8K0L9-2]
XP_006522475.1, XM_006522412.3 [Q8K0L9-1]
XP_006522476.1, XM_006522413.3 [Q8K0L9-1]
XP_006522477.1, XM_006522414.2 [Q8K0L9-1]
XP_006522478.1, XM_006522415.3 [Q8K0L9-1]
XP_006522479.1, XM_006522416.3 [Q8K0L9-1]
XP_006522481.1, XM_006522418.3 [Q8K0L9-1]
XP_006522485.1, XM_006522422.3 [Q8K0L9-2]
XP_006522487.1, XM_006522424.3 [Q8K0L9-2]
XP_011244291.1, XM_011245989.2 [Q8K0L9-1]
XP_011244292.1, XM_011245990.2 [Q8K0L9-1]
XP_017172580.1, XM_017317091.1 [Q8K0L9-1]
XP_017172581.1, XM_017317092.1 [Q8K0L9-1]
XP_017172582.1, XM_017317093.1 [Q8K0L9-1]
XP_017172583.1, XM_017317094.1 [Q8K0L9-1]
XP_017172584.1, XM_017317095.1 [Q8K0L9-1]
XP_017172585.1, XM_017317096.1 [Q8K0L9-1]
XP_017172586.1, XM_017317097.1 [Q8K0L9-1]
XP_017172587.1, XM_017317098.1 [Q8K0L9-1]
XP_017172588.1, XM_017317099.1 [Q8K0L9-2]
XP_017172589.1, XM_017317100.1 [Q8K0L9-2]
XP_017172590.1, XM_017317101.1 [Q8K0L9-2]
XP_017172591.1, XM_017317102.1 [Q8K0L9-2]
XP_017172592.1, XM_017317103.1 [Q8K0L9-2]
XP_017172593.1, XM_017317104.1 [Q8K0L9-2]
XP_017172594.1, XM_017317105.1 [Q8K0L9-2]
UniGeneiMm.136238
Mm.441121
Mm.441972
Mm.460947
Mm.487184
Mm.491236

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708 [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708 [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708 [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708 [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708 [Q8K0L9-1]
GeneIDi56490
KEGGimmu:56490
UCSCiuc007zga.3 mouse [Q8K0L9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF194030 mRNA Translation: AAF06015.1
AK005028 mRNA Translation: BAB23755.1
CT010512 Genomic DNA No translation available.
BC031114 mRNA Translation: AAH31114.1
BC056446 mRNA Translation: AAH56446.1
CCDSiCCDS28178.1 [Q8K0L9-1]
CCDS49851.1 [Q8K0L9-2]
RefSeqiNP_001272734.1, NM_001285805.1 [Q8K0L9-1]
NP_062752.2, NM_019778.2 [Q8K0L9-1]
NP_851401.1, NM_181058.1 [Q8K0L9-2]
XP_006522475.1, XM_006522412.3 [Q8K0L9-1]
XP_006522476.1, XM_006522413.3 [Q8K0L9-1]
XP_006522477.1, XM_006522414.2 [Q8K0L9-1]
XP_006522478.1, XM_006522415.3 [Q8K0L9-1]
XP_006522479.1, XM_006522416.3 [Q8K0L9-1]
XP_006522481.1, XM_006522418.3 [Q8K0L9-1]
XP_006522485.1, XM_006522422.3 [Q8K0L9-2]
XP_006522487.1, XM_006522424.3 [Q8K0L9-2]
XP_011244291.1, XM_011245989.2 [Q8K0L9-1]
XP_011244292.1, XM_011245990.2 [Q8K0L9-1]
XP_017172580.1, XM_017317091.1 [Q8K0L9-1]
XP_017172581.1, XM_017317092.1 [Q8K0L9-1]
XP_017172582.1, XM_017317093.1 [Q8K0L9-1]
XP_017172583.1, XM_017317094.1 [Q8K0L9-1]
XP_017172584.1, XM_017317095.1 [Q8K0L9-1]
XP_017172585.1, XM_017317096.1 [Q8K0L9-1]
XP_017172586.1, XM_017317097.1 [Q8K0L9-1]
XP_017172587.1, XM_017317098.1 [Q8K0L9-1]
XP_017172588.1, XM_017317099.1 [Q8K0L9-2]
XP_017172589.1, XM_017317100.1 [Q8K0L9-2]
XP_017172590.1, XM_017317101.1 [Q8K0L9-2]
XP_017172591.1, XM_017317102.1 [Q8K0L9-2]
XP_017172592.1, XM_017317103.1 [Q8K0L9-2]
XP_017172593.1, XM_017317104.1 [Q8K0L9-2]
XP_017172594.1, XM_017317105.1 [Q8K0L9-2]
UniGeneiMm.136238
Mm.441121
Mm.441972
Mm.460947
Mm.487184
Mm.491236

3D structure databases

ProteinModelPortaliQ8K0L9
SMRiQ8K0L9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0L9, 1 interactor
STRINGi10090.ENSMUSP00000078410

PTM databases

iPTMnetiQ8K0L9
PhosphoSitePlusiQ8K0L9

Proteomic databases

PaxDbiQ8K0L9
PeptideAtlasiQ8K0L9
PRIDEiQ8K0L9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079441; ENSMUSP00000078410; ENSMUSG00000022708 [Q8K0L9-1]
ENSMUST00000114690; ENSMUSP00000110338; ENSMUSG00000022708 [Q8K0L9-2]
ENSMUST00000114691; ENSMUSP00000110339; ENSMUSG00000022708 [Q8K0L9-2]
ENSMUST00000114694; ENSMUSP00000110342; ENSMUSG00000022708 [Q8K0L9-1]
ENSMUST00000114695; ENSMUSP00000110343; ENSMUSG00000022708 [Q8K0L9-1]
GeneIDi56490
KEGGimmu:56490
UCSCiuc007zga.3 mouse [Q8K0L9-1]

Organism-specific databases

CTDi26137
MGIiMGI:1929213 Zbtb20

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ8K0L9
KOiK10501
OMAiESTHCRK
OrthoDBiEOG091G02AP
PhylomeDBiQ8K0L9
TreeFamiTF335684

Miscellaneous databases

ChiTaRSiZbtb20 mouse
PROiPR:Q8K0L9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022708 Expressed in 301 organ(s), highest expression level in rostral migratory stream
CleanExiMM_ZBTB20
ExpressionAtlasiQ8K0L9 baseline and differential
GenevisibleiQ8K0L9 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT20_MOUSE
AccessioniPrimary (citable) accession number: Q8K0L9
Secondary accession number(s): A6X916, Q9DBD4, Q9QZ87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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