Zinc finger and BTB domain-containing protein 20

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia."
    Mitchelmore C., Kjaerulff K.M., Pedersen H.C., Nielsen J.V., Rasmussen T.E., Fisker M.F., Finsen B., Pedersen K.M., Jensen N.A.
    J. Biol. Chem. 277:7598-7609(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, HOMODIMERIZATION, TISSUE SPECIFICITY.
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver."
    Xie Z., Zhang H., Tsai W., Zhang Y., Du Y., Zhong J., Szpirer C., Zhu M., Cao X., Barton M.C., Grusby M.J., Zhang W.J.
    Proc Natl Acad Sci U S A 105:10859-10864(2008) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: UniProtKBInferred from direct assayⁱ
  • "Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20."
    Liu G., Zhou L., Zhang H., Chen R., Zhang Y., Li L., Lu J.Y., Jiang H., Liu D., Qi S., Jiang Y.M., Yin K., Xie Z., Shi Y., Liu Y., Cao X., Chen Y.X., Zou D., Zhang W.J.
    Nat Commun 8:14824-14824(2017) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to glucose stimulus Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20."
    Liu G., Zhou L., Zhang H., Chen R., Zhang Y., Li L., Lu J.Y., Jiang H., Liu D., Qi S., Jiang Y.M., Yin K., Xie Z., Shi Y., Liu Y., Cao X., Chen Y.X., Zou D., Zhang W.J.
    Nat Commun 8:14824-14824(2017) [PubMed] [Europe PMC] [Abstract]
• lipid homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20."
    Liu G., Zhou L., Zhang H., Chen R., Zhang Y., Li L., Lu J.Y., Jiang H., Liu D., Qi S., Jiang Y.M., Yin K., Xie Z., Shi Y., Liu Y., Cao X., Chen Y.X., Zou D., Zhang W.J.
    Nat Commun 8:14824-14824(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: CACAOInferred from mutant phenotypeⁱ
  • "Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription."
    Liu X., Zhang P., Bao Y., Han Y., Wang Y., Zhang Q., Zhan Z., Meng J., Li Y., Li N., Zhang W.J., Cao X.
    Proc Natl Acad Sci U S A 110:11097-11102(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: CACAOInferred from direct assayⁱ
  • "Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription."
    Liu X., Zhang P., Bao Y., Han Y., Wang Y., Zhang Q., Zhan Z., Meng J., Li Y., Li N., Zhang W.J., Cao X.
    Proc Natl Acad Sci U S A 110:11097-11102(2013) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver."
    Xie Z., Zhang H., Tsai W., Zhang Y., Du Y., Zhong J., Szpirer C., Zhu M., Cao X., Barton M.C., Grusby M.J., Zhang W.J.
    Proc Natl Acad Sci U S A 105:10859-10864(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of glycolytic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20."
    Liu G., Zhou L., Zhang H., Chen R., Zhang Y., Li L., Lu J.Y., Jiang H., Liu D., Qi S., Jiang Y.M., Yin K., Xie Z., Shi Y., Liu Y., Cao X., Chen Y.X., Zou D., Zhang W.J.
    Nat Commun 8:14824-14824(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-beta production Source: CACAOInferred from direct assayⁱ
  • "Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription."
    Liu X., Zhang P., Bao Y., Han Y., Wang Y., Zhang Q., Zhan Z., Meng J., Li Y., Li N., Zhang W.J., Cao X.
    Proc Natl Acad Sci U S A 110:11097-11102(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-6 production Source: CACAOInferred from direct assayⁱ
  • "Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription."
    Liu X., Zhang P., Bao Y., Han Y., Wang Y., Zhang Q., Zhan Z., Meng J., Li Y., Li N., Zhang W.J., Cao X.
    Proc Natl Acad Sci U S A 110:11097-11102(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of lipid biosynthetic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20."
    Liu G., Zhou L., Zhang H., Chen R., Zhang Y., Li L., Lu J.Y., Jiang H., Liu D., Qi S., Jiang Y.M., Yin K., Xie Z., Shi Y., Liu Y., Cao X., Chen Y.X., Zou D., Zhang W.J.
    Nat Commun 8:14824-14824(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: CACAOInferred from direct assayⁱ
  • "Zinc finger protein ZBTB20 promotes Toll-like receptor-triggered innate immune responses by repressing IkappaBalpha gene transcription."
    Liu X., Zhang P., Bao Y., Han Y., Wang Y., Zhang Q., Zhan Z., Meng J., Li Y., Li N., Zhang W.J., Cao X.
    Proc Natl Acad Sci U S A 110:11097-11102(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH 
        60         70         80         90        100
STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR 
       110        120        130        140        150
GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS 
       160        170        180        190        200
VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV 
       210        220        230        240        250
FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC 
       260        270        280        290        300
SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER 
       310        320        330        340        350
YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER 
       360        370        380        390        400
NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR 
       410        420        430        440        450
DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN 
       460        470        480        490        500
SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI 
       510        520        530        540        550
GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF 
       560        570        580        590        600
TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH 
       610        620        630        640        650
TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN 
       660        670        680        690        700
VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR 
       710        720        730        740 
AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G          

        10         20         30         40         50
MTERIHSINL HNFSNSVLET LNEQRNRGHF CDVTVRIHGS MLRAHRCVLA 
        60         70         80         90        100
AGSPFFQDKL LLGYSDIEIP SVVSVQSVQK LIDFMYSGVL RVSQSEALQI 
       110        120        130        140        150
LTAASILQIK TVIDECTRIV SQNVGDVFPG IQDSGQDTPR GTPESGTSGQ 
       160        170        180        190        200
SSDTESGYLQ SHPQHSVDRI YSALYACSMQ NGSGERSFYS GAVVSHHETA 
       210        220        230        240        250
LGLPRDHHME DPSWITRIHE RSQQMERYLS TTPETTHCRK QPRPVRIQTL 
       260        270        280        290        300
VGNIHIKQEM EDDYDYYGQQ RVQILERNES EECTEDTDQA EGTESEPKGE 
       310        320        330        340        350
SFDSGVSSSI GTEPDSVEQQ FGAAAPRDGQ AEPAQPEQAA EAPAESSAQP 
       360        370        380        390        400
NQLEPGASSP ERSNESEMDN TVITVSNSSD KGVLQQPSVN TSIGQPLPST 
       410        420        430        440        450
QLYLRQTETL TSNLRMPLTL TSNTQVIGTA GNTYLPALFT TQPAGSGPKP 
       460        470        480        490        500
FLFSLPQPLT GQQTQFVTVS QPGLSTFTAQ LPAPQPLASS AGHSTASGQG 
       510        520        530        540        550
DKKPYECTLC NKTFTAKQNY VKHMFVHTGE KPHQCSICWR SFSLKDYLIK 
       560        570        580        590        600
HMVTHTGVRA YQCSICNKRF TQKSSLNVHM RLHRGEKSYE CYICKKKFSH 
       610        620        630        640        650
KTLLERHVAL HSASNGTPPA GTPPGARAGP PGVVACTEGT TYVCSVCPAK 
       660 
FDQIEQFNDH MRMHVSDG                                    

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot