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Protein

Ankyrin repeat and SOCS box protein 2

Gene

Asb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • myoblast differentiation Source: MGI
  • protein polyubiquitination Source: MGI
  • protein ubiquitination Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • ubiquitin-dependent protein catabolic process Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 2
Short name:
ASB-2
Gene namesi
Name:Asb2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1929743 Asb2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333031 – 634Ankyrin repeat and SOCS box protein 2Add BLAST634

Proteomic databases

PaxDbiQ8K0L0
PRIDEiQ8K0L0

PTM databases

iPTMnetiQ8K0L0
PhosphoSitePlusiQ8K0L0

Expressioni

Tissue specificityi

Highest expression in muscle, heart and spleen.1 Publication

Gene expression databases

BgeeiENSMUSG00000021200 Expressed in 135 organ(s), highest expression level in quadriceps femoris
CleanExiMM_ASB2
GenevisibleiQ8K0L0 MM

Interactioni

Subunit structurei

Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (ELOB and ELOC) and ASB2.By similarity

Protein-protein interaction databases

BioGridi211145, 2 interactors
IntActiQ8K0L0, 1 interactor
STRINGi10090.ENSMUSP00000021617

Structurei

3D structure databases

ProteinModelPortaliQ8K0L0
SMRiQ8K0L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 45UIMPROSITE-ProRule annotationAdd BLAST20
Repeati104 – 133ANK 1Sequence analysisAdd BLAST30
Repeati137 – 167ANK 2Sequence analysisAdd BLAST31
Repeati171 – 200ANK 3Sequence analysisAdd BLAST30
Repeati204 – 233ANK 4Sequence analysisAdd BLAST30
Repeati237 – 266ANK 5Sequence analysisAdd BLAST30
Repeati270 – 299ANK 6Sequence analysisAdd BLAST30
Repeati303 – 332ANK 7Sequence analysisAdd BLAST30
Repeati336 – 365ANK 8Sequence analysisAdd BLAST30
Repeati368 – 397ANK 9Sequence analysisAdd BLAST30
Repeati410 – 439ANK 10Sequence analysisAdd BLAST30
Repeati440 – 469ANK 11Sequence analysisAdd BLAST30
Repeati476 – 504ANK 12Sequence analysisAdd BLAST29
Domaini580 – 634SOCS boxPROSITE-ProRule annotationAdd BLAST55

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150873
HOGENOMiHOG000034086
HOVERGENiHBG104037
InParanoidiQ8K0L0
KOiK10324
OMAiNADTNHR
OrthoDBiEOG091G05RD
PhylomeDBiQ8K0L0
TreeFamiTF315127

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR003903 UIM_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 8 hits
PS50225 SOCS, 1 hit
PS50330 UIM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q8K0L0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEISTRGR QRAIGHEEYS LYSSLSEEEL LQMAIEQSLA DKTRGPTPAE
60 70 80 90 100
ASASSQTNHQ PGHFHPWTRS PSSPENPPAR APLGLFQGVM QKYSSNLFKT
110 120 130 140 150
SQMAAMDPVL KAIKEGDEEA LKIMIQDGKN LAEPNKEGWL PLHEAAYYGQ
160 170 180 190 200
LGCLKVLQQA YPGTIDQRTL QEETALYLAT CREHLDCLLS LLQAGAEPDI
210 220 230 240 250
SNKSRETPLY KACERKNAEA VRILVRYNAD ANHRCNRGWT ALHESVSRND
260 270 280 290 300
LEVMEILVSG GAKVEAKNVY SITPLFVAAQ SGQLEALRFL AKHGADINTQ
310 320 330 340 350
ASDSASALYE ASKNEHEDVV EFLLSQGADA NKANKDGLLP LHVASKKGNY
360 370 380 390 400
RIVQMLLPVT SRTRVRRSGI SPLHLAAERN HDAVLEALLA ARFDVNAPLA
410 420 430 440 450
PERARLYEDR RSSALYFAVV NNNVYATELL LLAGADPNRD VISPLLVAIR
460 470 480 490 500
HGCLRTMQLL LDHGANIDAY IATHPTAFPA TIMFAMKCLS LLKFLMDLGC
510 520 530 540 550
DGEPCFSCLY GNGPHPPAPR PGRFHDAPVD DKAPSVVQFC EFLSAPEVSR
560 570 580 590 600
WAGPIIDVLL DYVGNVQLCS RLKEHIDSFE DWAVIKEKAE PPRPLAHLCR
610 620 630
LRVRKAIGKY RIKLLDTLPL PGRLIRYLKY ENTQ
Length:634
Mass (Da):70,221
Last modified:October 1, 2002 - v1
Checksum:iE320CEBD39891D41
GO
Isoform 21 Publication (identifier: Q8K0L0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     49-68: AEASASSQTNHQPGHFHPWT → MTRFSYAEYFALFHSGSAPS

Show »
Length:586
Mass (Da):64,937
Checksum:i79D011C89B571DEC
GO

Sequence cautioni

The sequence AAD38809 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72 – 73SS → LF in AAD38809 (PubMed:11111040).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0520251 – 48Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_05202649 – 68AEASA…FHPWT → MTRFSYAEYFALFHSGSAPS in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155353 mRNA Translation: AAD38809.2 Different initiation.
BC031161 mRNA Translation: AAH31161.1
AK003566 mRNA Translation: BAB22862.1
CCDSiCCDS26128.1 [Q8K0L0-1]
RefSeqiNP_075536.1, NM_023049.1 [Q8K0L0-1]
UniGeneiMm.27159
Mm.321278

Genome annotation databases

EnsembliENSMUST00000021617; ENSMUSP00000021617; ENSMUSG00000021200 [Q8K0L0-1]
ENSMUST00000149431; ENSMUSP00000117595; ENSMUSG00000021200 [Q8K0L0-2]
GeneIDi65256
KEGGimmu:65256
UCSCiuc007ovc.1 mouse [Q8K0L0-1]
uc007ovd.1 mouse [Q8K0L0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155353 mRNA Translation: AAD38809.2 Different initiation.
BC031161 mRNA Translation: AAH31161.1
AK003566 mRNA Translation: BAB22862.1
CCDSiCCDS26128.1 [Q8K0L0-1]
RefSeqiNP_075536.1, NM_023049.1 [Q8K0L0-1]
UniGeneiMm.27159
Mm.321278

3D structure databases

ProteinModelPortaliQ8K0L0
SMRiQ8K0L0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211145, 2 interactors
IntActiQ8K0L0, 1 interactor
STRINGi10090.ENSMUSP00000021617

PTM databases

iPTMnetiQ8K0L0
PhosphoSitePlusiQ8K0L0

Proteomic databases

PaxDbiQ8K0L0
PRIDEiQ8K0L0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021617; ENSMUSP00000021617; ENSMUSG00000021200 [Q8K0L0-1]
ENSMUST00000149431; ENSMUSP00000117595; ENSMUSG00000021200 [Q8K0L0-2]
GeneIDi65256
KEGGimmu:65256
UCSCiuc007ovc.1 mouse [Q8K0L0-1]
uc007ovd.1 mouse [Q8K0L0-2]

Organism-specific databases

CTDi51676
MGIiMGI:1929743 Asb2

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150873
HOGENOMiHOG000034086
HOVERGENiHBG104037
InParanoidiQ8K0L0
KOiK10324
OMAiNADTNHR
OrthoDBiEOG091G05RD
PhylomeDBiQ8K0L0
TreeFamiTF315127

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8K0L0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021200 Expressed in 135 organ(s), highest expression level in quadriceps femoris
CleanExiMM_ASB2
GenevisibleiQ8K0L0 MM

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001496 SOCS_box
IPR036036 SOCS_box-like_dom_sf
IPR003903 UIM_dom
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF13606 Ank_3, 1 hit
PF07525 SOCS_box, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 11 hits
SM00253 SOCS, 1 hit
SM00969 SOCS_box, 1 hit
SUPFAMiSSF158235 SSF158235, 1 hit
SSF48403 SSF48403, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 8 hits
PS50225 SOCS, 1 hit
PS50330 UIM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASB2_MOUSE
AccessioniPrimary (citable) accession number: Q8K0L0
Secondary accession number(s): Q9CTH4, Q9WV73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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