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Protein

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

Gene

B3gnt7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues (By similarity).By similarity1 Publication

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • acetylglucosaminyltransferase activity Source: MGI
  • galactosyltransferase activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.149 3474
ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-913709 O-linked glycosylation of mucins
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (EC:2.4.1.-)
Short name:
BGnT-7
Short name:
Beta-1,3-Gn-T7
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 7
Short name:
Beta3Gn-T7
Gene namesi
Name:B3gnt7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2384394 B3gnt7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 26HelicalSequence analysisAdd BLAST20
Topological domaini27 – 397LumenalSequence analysisAdd BLAST371

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002646191 – 397UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi387N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8K0J2
PaxDbiQ8K0J2
PRIDEiQ8K0J2

PTM databases

PhosphoSitePlusiQ8K0J2

Expressioni

Tissue specificityi

Strongly expressed in placenta and colon. Moderately expressed in lung, stomach, small intestine and kidney. Very weakly expressed in cerebrum, cerebellum, heart and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000079445 Expressed in 72 organ(s), highest expression level in left colon
ExpressionAtlasiQ8K0J2 baseline and differential
GenevisibleiQ8K0J2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108931

Structurei

3D structure databases

SMRiQ8K0J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOGENOMiHOG000232195
HOVERGENiHBG050653
InParanoidiQ8K0J2
KOiK09664
OMAiAMWGLVH
OrthoDBiEOG091G0AXM
PhylomeDBiQ8K0J2
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q8K0J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLWKKTLYK SVCLALALLV AVTVFQRSVT PGQFLQDPLP PTPGPAKTGN
60 70 80 90 100
LVNPNSFWKS SKDVAAPTPT VPRGPQVWDV ITTNCSININ LTHQPWFQSL
110 120 130 140 150
EPHFRQFLAY RHCRYFPMLL NHPEKCAGDV YMLVVVKSVI TQHDRREVIR
160 170 180 190 200
QTWGHEWESA GLGRGAVRTL FLLGTASKQE ERTHYQQLLA YEDRLYADIL
210 220 230 240 250
QWDFLDSFFN LTLKEIHFLK WLDIYCPNVP FVFKGDDDVF VNPTNLLEFL
260 270 280 290 300
SDRQPQENLF VGDVLKHARP IRKKDNKYYI PAVMYGKATY PPYAGGGGFL
310 320 330 340 350
MSGSLARQLH HACDTLELFP IDDVFLGMCL EVLGVKPTGH EGFKTFGISR
360 370 380 390
VRSSRMNKEP CFYRAMLVVH KLLPAELLAM WDLVHSNLTC SVKFQVL
Length:397
Mass (Da):45,379
Last modified:December 12, 2006 - v2
Checksum:iA6345D03412DD48B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQY3A0A087WQY3_MOUSE
Hexosyltransferase
B3gnt7
155Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203D → N in BAC37824 (PubMed:16141072).Curated1
Sequence conflicti208F → S in AAH31187 (PubMed:15489334).Curated1
Sequence conflicti271I → T in AAM61769 (PubMed:12061784).Curated1
Sequence conflicti290Y → H in BAE20915 (PubMed:16141072).Curated1
Sequence conflicti395Q → R in AAH31187 (PubMed:15489334).Curated1
Sequence conflicti395Q → R in AAH60507 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502429 mRNA Translation: AAM61769.1
AK080081 mRNA Translation: BAC37824.1
AK131975 mRNA Translation: BAE20915.1
AK154691 mRNA Translation: BAE32766.1
BC031187 mRNA Translation: AAH31187.1
BC060507 mRNA Translation: AAH60507.1
CCDSiCCDS35645.1
RefSeqiNP_660257.2, NM_145222.2
UniGeneiMm.86467

Genome annotation databases

EnsembliENSMUST00000113306; ENSMUSP00000108931; ENSMUSG00000079445
GeneIDi227327
KEGGimmu:227327
UCSCiuc007bvk.2 mouse

Similar proteinsi

Entry informationi

Entry nameiB3GN7_MOUSE
AccessioniPrimary (citable) accession number: Q8K0J2
Secondary accession number(s): Q3U3L9
, Q3V283, Q6PA02, Q8BJS5, Q8K437
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: September 12, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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