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Protein

Solute carrier family 45 member 3

Gene

Slc45a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • sucrose:proton symporter activity Source: MGI

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 45 member 3
Alternative name(s):
Prostate cancer-associated protein 6
Prostein
Gene namesi
Name:Slc45a3
Synonyms:Pcanap6, Prst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1922082 Slc45a3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei52 – 72Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei120 – 140Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei161 – 181Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei198 – 218Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei323 – 343Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei353 – 373Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei382 – 402Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei522 – 542Helical; Name=11Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225211 – 553Solute carrier family 45 member 3Add BLAST553

Proteomic databases

PaxDbiQ8K0H7
PRIDEiQ8K0H7

PTM databases

PhosphoSitePlusiQ8K0H7

Expressioni

Tissue specificityi

Expressed in the epididymis.1 Publication

Gene expression databases

BgeeiENSMUSG00000026435 Expressed in 211 organ(s), highest expression level in primary oocyte
CleanExiMM_SLC45A3
ExpressionAtlasiQ8K0H7 baseline and differential
GenevisibleiQ8K0H7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027695

Structurei

3D structure databases

ProteinModelPortaliQ8K0H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00390000018882
HOGENOMiHOG000013046
HOVERGENiHBG053519
InParanoidiQ8K0H7
KOiK15379
OMAiACDVSMR
OrthoDBiEOG091G0DTJ
PhylomeDBiQ8K0H7
TreeFamiTF325412

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8K0H7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQRLWASRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE
60 70 80 90 100
KFMTMVLGIG PVLGLVSVPL LGSASDQWRG RYGRRRPFIW ALSLGVLLSL
110 120 130 140 150
FLIPRAGWLA GLLYPDTRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL
160 170 180 190 200
FRDPDHCRQA FSVYAFMISL GGCLGYLLPA IDWDTSVLAP YLGTQEECLF
210 220 230 240 250
GLLTLIFLIC MAATLFVTEE AVLGPPEPAE GLLVSAVSRR CCPCHVGLAF
260 270 280 290 300
RNLGTLFPRL QQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
310 320 330 340 350
YQGVPRAEPG TEARRHYDEG IRMGSLGLFL QCAISLVFSL VMDRLVQKFG
360 370 380 390 400
TRSVYLASVM TFPVAAAATC LSHSVVVVTA SAALTGFTFS ALQILPYTLA
410 420 430 440 450
SLYHREKQVF LPKYRGDAGG SSGEDSQTTS FLPGPKPGAL FPNGHVGSGS
460 470 480 490 500
SGILAPPPAL CGASACDVSM RVVVGEPPEA RVVTGRGICL DLAILDSAFL
510 520 530 540 550
LSQVAPSLFM GSIVQLSHSV TAYMVSAAGL GLVAIYFATQ VVFDKNDLAK

YSV
Length:553
Mass (Da):59,742
Last modified:October 1, 2002 - v1
Checksum:i6A474FEA630B4B13
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRT6A0A087WRT6_MOUSE
Solute carrier family 45 member 3
Slc45a3
221Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035428 mRNA Translation: BAC29063.1
BC024519 mRNA Translation: AAH24519.1
BC031381 mRNA Translation: AAH31381.1
BC034084 mRNA Translation: AAH34084.1
CCDSiCCDS15278.1
RefSeqiNP_001171099.1, NM_001177628.2
NP_666089.1, NM_145977.2
XP_006529404.1, XM_006529341.2
XP_006529405.1, XM_006529342.2
UniGeneiMm.200307

Genome annotation databases

EnsembliENSMUST00000027695; ENSMUSP00000027695; ENSMUSG00000026435
ENSMUST00000177943; ENSMUSP00000136190; ENSMUSG00000026435
GeneIDi212980
KEGGimmu:212980
UCSCiuc007cnz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035428 mRNA Translation: BAC29063.1
BC024519 mRNA Translation: AAH24519.1
BC031381 mRNA Translation: AAH31381.1
BC034084 mRNA Translation: AAH34084.1
CCDSiCCDS15278.1
RefSeqiNP_001171099.1, NM_001177628.2
NP_666089.1, NM_145977.2
XP_006529404.1, XM_006529341.2
XP_006529405.1, XM_006529342.2
UniGeneiMm.200307

3D structure databases

ProteinModelPortaliQ8K0H7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027695

PTM databases

PhosphoSitePlusiQ8K0H7

Proteomic databases

PaxDbiQ8K0H7
PRIDEiQ8K0H7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027695; ENSMUSP00000027695; ENSMUSG00000026435
ENSMUST00000177943; ENSMUSP00000136190; ENSMUSG00000026435
GeneIDi212980
KEGGimmu:212980
UCSCiuc007cnz.2 mouse

Organism-specific databases

CTDi85414
MGIiMGI:1922082 Slc45a3

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00390000018882
HOGENOMiHOG000013046
HOVERGENiHBG053519
InParanoidiQ8K0H7
KOiK15379
OMAiACDVSMR
OrthoDBiEOG091G0DTJ
PhylomeDBiQ8K0H7
TreeFamiTF325412

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport

Miscellaneous databases

PROiPR:Q8K0H7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026435 Expressed in 211 organ(s), highest expression level in primary oocyte
CleanExiMM_SLC45A3
ExpressionAtlasiQ8K0H7 baseline and differential
GenevisibleiQ8K0H7 MM

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS45A3_MOUSE
AccessioniPrimary (citable) accession number: Q8K0H7
Secondary accession number(s): Q8K252, Q8R1I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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