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Protein

Transcription initiation factor TFIID subunit 10

Gene

Taf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May regulate cyclin E expression.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 10
Alternative name(s):
Transcription initiation factor TFIID 30 kDa subunit
Short name:
TAF(II)30
Short name:
TAFII-30
Short name:
TAFII30
Short name:
mTAFII30
Gene namesi
Name:Taf10
Synonyms:Taf2h, Tafii30
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1346320 Taf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001188982 – 218Transcription initiation factor TFIID subunit 10Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei48PhosphothreonineBy similarity1
Modified residuei189Allysine; alternateBy similarity1
Modified residuei189N6,N6,N6-trimethyllysine; alternate1 Publication1

Post-translational modificationi

Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II.By similarity
Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8K0H5
MaxQBiQ8K0H5
PaxDbiQ8K0H5
PeptideAtlasiQ8K0H5
PRIDEiQ8K0H5

PTM databases

iPTMnetiQ8K0H5
PhosphoSitePlusiQ8K0H5

Expressioni

Gene expression databases

BgeeiENSMUSG00000043866 Expressed in 206 organ(s), highest expression level in embryo
GenevisibleiQ8K0H5 MM

Interactioni

Subunit structurei

TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22 (By similarity). Interacts with TAF3 (PubMed:11438666). Interacts with LOXL2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204885, 2 interactors
ComplexPortaliCPX-1024 PCAF histone acetylase complex
CPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8K0H5
DIPiDIP-59890N
IntActiQ8K0H5, 6 interactors
MINTiQ8K0H5
STRINGi10090.ENSMUSP00000118105

Structurei

3D structure databases

ProteinModelPortaliQ8K0H5
SMRiQ8K0H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi187 – 189[KR]-[STA]-K motif3

Domaini

The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.By similarity

Sequence similaritiesi

Belongs to the TAF10 family.Curated

Phylogenomic databases

eggNOGiKOG3423 Eukaryota
COG5162 LUCA
GeneTreeiENSGT00390000009368
HOGENOMiHOG000285966
HOVERGENiHBG079227
InParanoidiQ8K0H5
KOiK03134
OMAiCIANDNA
OrthoDBiEOG091G0UWA
PhylomeDBiQ8K0H5
TreeFamiTF313156

Family and domain databases

CDDicd07982 TAF10, 1 hit
InterProiView protein in InterPro
IPR003923 TFIID_30kDa
PANTHERiPTHR21242 PTHR21242, 1 hit
PfamiView protein in Pfam
PF03540 TFIID_30kDa, 1 hit
PIRSFiPIRSF017246 TFIID_TAF10, 1 hit
PRINTSiPR01443 TFIID30KDSUB

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K0H5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCSGSGADP EAATACAASV AGPAPLVSAP AALPTSTAAE SKASPAGTAG
60 70 80 90 100
GPVAGVATAG TGPVAARAGE PAERRGPASV AAGGAAPPEG AMSNGVYALP
110 120 130 140 150
SAANGEVKPV VSSTPLVDFL MQLEDYTPTI PDAVTGYYLN RAGFEASDPR
160 170 180 190 200
IIRLISLAAQ KFISDIANDA LQHCKMKGTA SGSSRSKSKD RKYTLTMEDL
210
TPALSEYGIN VKKPHYFT
Length:218
Mass (Da):21,841
Last modified:October 1, 2002 - v1
Checksum:i4ACD72C59ACC367A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → G in BAC32964 (PubMed:16141072).Curated1
Sequence conflicti29 – 31APA → GSP in CAB59510 (PubMed:10469660).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047115 mRNA Translation: BAC32964.1
AJ249987 Genomic DNA Translation: CAB59510.1
BC031418 mRNA Translation: AAH31418.1
BC080311 mRNA Translation: AAH80311.1
CCDSiCCDS21660.1
RefSeqiNP_064408.2, NM_020024.3
UniGeneiMm.274846
Mm.285771

Genome annotation databases

EnsembliENSMUST00000141116; ENSMUSP00000118105; ENSMUSG00000043866
GeneIDi24075
KEGGimmu:24075
UCSCiuc009izf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047115 mRNA Translation: BAC32964.1
AJ249987 Genomic DNA Translation: CAB59510.1
BC031418 mRNA Translation: AAH31418.1
BC080311 mRNA Translation: AAH80311.1
CCDSiCCDS21660.1
RefSeqiNP_064408.2, NM_020024.3
UniGeneiMm.274846
Mm.285771

3D structure databases

ProteinModelPortaliQ8K0H5
SMRiQ8K0H5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204885, 2 interactors
ComplexPortaliCPX-1024 PCAF histone acetylase complex
CPX-916 TFTC histone acetylation complex
CPX-920 SAGA complex
CPX-932 General transcription factor complex TFIID
CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMiQ8K0H5
DIPiDIP-59890N
IntActiQ8K0H5, 6 interactors
MINTiQ8K0H5
STRINGi10090.ENSMUSP00000118105

PTM databases

iPTMnetiQ8K0H5
PhosphoSitePlusiQ8K0H5

Proteomic databases

EPDiQ8K0H5
MaxQBiQ8K0H5
PaxDbiQ8K0H5
PeptideAtlasiQ8K0H5
PRIDEiQ8K0H5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141116; ENSMUSP00000118105; ENSMUSG00000043866
GeneIDi24075
KEGGimmu:24075
UCSCiuc009izf.1 mouse

Organism-specific databases

CTDi6881
MGIiMGI:1346320 Taf10

Phylogenomic databases

eggNOGiKOG3423 Eukaryota
COG5162 LUCA
GeneTreeiENSGT00390000009368
HOGENOMiHOG000285966
HOVERGENiHBG079227
InParanoidiQ8K0H5
KOiK03134
OMAiCIANDNA
OrthoDBiEOG091G0UWA
PhylomeDBiQ8K0H5
TreeFamiTF313156

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-6804756 Regulation of TP53 Activity through Phosphorylation
R-MMU-73776 RNA Polymerase II Promoter Escape
R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-MMU-75953 RNA Polymerase II Transcription Initiation
R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

PROiPR:Q8K0H5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043866 Expressed in 206 organ(s), highest expression level in embryo
GenevisibleiQ8K0H5 MM

Family and domain databases

CDDicd07982 TAF10, 1 hit
InterProiView protein in InterPro
IPR003923 TFIID_30kDa
PANTHERiPTHR21242 PTHR21242, 1 hit
PfamiView protein in Pfam
PF03540 TFIID_30kDa, 1 hit
PIRSFiPIRSF017246 TFIID_TAF10, 1 hit
PRINTSiPR01443 TFIID30KDSUB
ProtoNetiSearch...

Entry informationi

Entry nameiTAF10_MOUSE
AccessioniPrimary (citable) accession number: Q8K0H5
Secondary accession number(s): Q8C8H2, Q9QYY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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