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Protein

EARP and GARP complex-interacting protein 1

Gene

Eipr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex.By similarity

GO - Biological processi

  • positive regulation of dense core granule transport Source: UniProtKB
  • protein ubiquitination Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
EARP and GARP complex-interacting protein 1By similarity
Alternative name(s):
Endosome-associated recycling protein-interacting proteinBy similarity
Golgi-associated retrograde protein-interacting proteinBy similarity
Tumor-suppressing STF cDNA 1 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 1 proteinBy similarity
Gene namesi
Name:Eipr1Imported
Synonyms:Tssc1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1289332 Eipr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513001 – 386EARP and GARP complex-interacting protein 1Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K0G5
MaxQBiQ8K0G5
PaxDbiQ8K0G5
PeptideAtlasiQ8K0G5
PRIDEiQ8K0G5

PTM databases

iPTMnetiQ8K0G5
PhosphoSitePlusiQ8K0G5

Expressioni

Gene expression databases

BgeeiENSMUSG00000036613 Expressed in 257 organ(s), highest expression level in blood
CleanExiMM_TSSC1
ExpressionAtlasiQ8K0G5 baseline and differential
GenevisibleiQ8K0G5 MM

Interactioni

Subunit structurei

Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits. Interacts with SNAP29.By similarity

Protein-protein interaction databases

IntActiQ8K0G5, 1 interactor
MINTiQ8K0G5
STRINGi10090.ENSMUSP00000038845

Structurei

3D structure databases

ProteinModelPortaliQ8K0G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati132 – 172WD 1Add BLAST41
Repeati182 – 222WD 2Add BLAST41
Repeati226 – 266WD 3Add BLAST41
Repeati270 – 310WD 4Add BLAST41
Repeati344 – 384WD 5Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat EIPR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1007 Eukaryota
ENOG410XRIE LUCA
GeneTreeiENSGT00730000111137
HOGENOMiHOG000264967
HOVERGENiHBG052937
InParanoidiQ8K0G5
OMAiATCYNKT
OrthoDBiEOG091G0DR3
TreeFamiTF105847

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8K0G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDAPVIYG LEFQARALTP QTAETDAIRF LVGTQSLKYD NQIHIIDFDD
60 70 80 90 100
ENNIINKNVL LHQAGEIWHI SASPADKGVL ATCYNKTTDS RVQACAAVWR
110 120 130 140 150
MPKELESGSH ESPDDPASTA QTLELLCHLD NSAQGNVACV VWEPMGDGKK
160 170 180 190 200
VISLADSHIL LWDLQPSSSQ AVLASSATLE GRGQLKFTAG RWSPHHNCTQ
210 220 230 240 250
VATASDTTLR GWDTRSMSQI YCIENAHGQL VRDLDFNPNK QYYLASCGDD
260 270 280 290 300
CKVKFWDTRN VTEPVKTLEE HSHWVWSVRY NHSHDQLVLT GSSDSRVILS
310 320 330 340 350
NMVSISSEPF GHLVDDGDIS DPEEHHAEKS KEPLQDNVIA TYEEHEDSVY
360 370 380
AVDWASADPW LFASLSYDGR LVINRVPRAL KYHILL
Length:386
Mass (Da):43,127
Last modified:July 27, 2011 - v2
Checksum:iD555D19FB7D700F4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VN36A0A1Y7VN36_MOUSE
EARP and GARP complex-interacting p...
Eipr1 Tssc1
172Annotation score:
A0A1Y7VIQ7A0A1Y7VIQ7_MOUSE
EARP and GARP complex-interacting p...
Eipr1 Tssc1
37Annotation score:
A0A217FL60A0A217FL60_MOUSE
EARP and GARP complex-interacting p...
Eipr1
135Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317 – 319GDI → DDV in AAH31458 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA No translation available.
CT010449 Genomic DNA No translation available.
BC031458 mRNA Translation: AAH31458.1
CCDSiCCDS25855.1
RefSeqiNP_958745.2, NM_201357.2
UniGeneiMm.273724

Genome annotation databases

EnsembliENSMUST00000221877; ENSMUSP00000152220; ENSMUSG00000036613
GeneIDi380752
KEGGimmu:380752
UCSCiuc007ngb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136986 Genomic DNA No translation available.
CT010449 Genomic DNA No translation available.
BC031458 mRNA Translation: AAH31458.1
CCDSiCCDS25855.1
RefSeqiNP_958745.2, NM_201357.2
UniGeneiMm.273724

3D structure databases

ProteinModelPortaliQ8K0G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K0G5, 1 interactor
MINTiQ8K0G5
STRINGi10090.ENSMUSP00000038845

PTM databases

iPTMnetiQ8K0G5
PhosphoSitePlusiQ8K0G5

Proteomic databases

EPDiQ8K0G5
MaxQBiQ8K0G5
PaxDbiQ8K0G5
PeptideAtlasiQ8K0G5
PRIDEiQ8K0G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000221877; ENSMUSP00000152220; ENSMUSG00000036613
GeneIDi380752
KEGGimmu:380752
UCSCiuc007ngb.2 mouse

Organism-specific databases

CTDi7260
MGIiMGI:1289332 Eipr1

Phylogenomic databases

eggNOGiKOG1007 Eukaryota
ENOG410XRIE LUCA
GeneTreeiENSGT00730000111137
HOGENOMiHOG000264967
HOVERGENiHBG052937
InParanoidiQ8K0G5
OMAiATCYNKT
OrthoDBiEOG091G0DR3
TreeFamiTF105847

Miscellaneous databases

ChiTaRSiTssc1 mouse
PROiPR:Q8K0G5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036613 Expressed in 257 organ(s), highest expression level in blood
CleanExiMM_TSSC1
ExpressionAtlasiQ8K0G5 baseline and differential
GenevisibleiQ8K0G5 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIPR1_MOUSE
AccessioniPrimary (citable) accession number: Q8K0G5
Secondary accession number(s): E9QN80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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