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Protein

Cyclin-dependent kinase 17

Gene

Cdk17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei221ATPPROSITE-ProRule annotation1
Active sitei313Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 17 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene namesi
Name:Cdk17
Synonyms:Pctaire2, Pctk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97517 Cdk17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864881 – 523Cyclin-dependent kinase 17Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei146PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K0D0
PaxDbiQ8K0D0
PRIDEiQ8K0D0

PTM databases

iPTMnetiQ8K0D0
PhosphoSitePlusiQ8K0D0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020015 Expressed in 241 organ(s), highest expression level in olfactory tubercle
CleanExiMM_PCTK2
ExpressionAtlasiQ8K0D0 baseline and differential
GenevisibleiQ8K0D0 MM

Interactioni

Subunit structurei

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.1 Publication

Protein-protein interaction databases

BioGridi231880, 1 interactor
STRINGi10090.ENSMUSP00000070355

Structurei

3D structure databases

ProteinModelPortaliQ8K0D0
SMRiQ8K0D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 473Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ8K0D0
KOiK15595
OrthoDBiEOG091G0CH0
PhylomeDBiQ8K0D0
TreeFamiTF106508

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8K0D0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT
60 70 80 90 100
SHSVHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN
110 120 130 140 150
LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD
160 170 180 190 200
IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE
210 220 230 240 250
GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI
260 270 280 290 300
VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGNIMSMHNV KLFLYQILRG
310 320 330 340 350
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV
360 370 380 390 400
TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL
410 420 430 440 450
IFRLLGTPSQ ETWPGVSSND EFKNYNFPKY KPQPLINHAP RLDSEGIELI
460 470 480 490 500
TKFLQYESKK RVPAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD
510 520
PGFRNSSYPE TGHGKNRRQS MLF
Length:523
Mass (Da):59,506
Last modified:June 21, 2004 - v2
Checksum:i847B045A3BCE4628
GO
Isoform 2 (identifier: Q8K0D0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     512-523: GHGKNRRQSMLF → ALS

Show »
Length:430
Mass (Da):48,974
Checksum:iA0386728D25CBC62
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUS7A0A1L1SUS7_MOUSE
Cyclin-dependent kinase 17
Cdk17
481Annotation score:
A0A1L1SR36A0A1L1SR36_MOUSE
Cyclin-dependent kinase 17
Cdk17
71Annotation score:
A0A1L1SUA6A0A1L1SUA6_MOUSE
Cyclin-dependent kinase 17
Cdk17
39Annotation score:
A0A1L1SSL3A0A1L1SSL3_MOUSE
Cyclin-dependent kinase 17
Cdk17
10Annotation score:

Sequence cautioni

The sequence AAH31778 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0106401 – 84Missing in isoform 2. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_010641512 – 523GHGKN…QSMLF → ALS in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031778 mRNA Translation: AAH31778.1 Different initiation.
BC064815 mRNA Translation: AAH64815.1
CCDSiCCDS48670.1 [Q8K0D0-1]
RefSeqiNP_666351.2, NM_146239.2 [Q8K0D0-1]
XP_006513690.1, XM_006513627.2 [Q8K0D0-1]
XP_011241749.1, XM_011243447.2 [Q8K0D0-1]
UniGeneiMm.217404
Mm.479520

Genome annotation databases

EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015 [Q8K0D0-1]
GeneIDi237459
KEGGimmu:237459
UCSCiuc007gul.2 mouse [Q8K0D0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC031778 mRNA Translation: AAH31778.1 Different initiation.
BC064815 mRNA Translation: AAH64815.1
CCDSiCCDS48670.1 [Q8K0D0-1]
RefSeqiNP_666351.2, NM_146239.2 [Q8K0D0-1]
XP_006513690.1, XM_006513627.2 [Q8K0D0-1]
XP_011241749.1, XM_011243447.2 [Q8K0D0-1]
UniGeneiMm.217404
Mm.479520

3D structure databases

ProteinModelPortaliQ8K0D0
SMRiQ8K0D0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231880, 1 interactor
STRINGi10090.ENSMUSP00000070355

PTM databases

iPTMnetiQ8K0D0
PhosphoSitePlusiQ8K0D0

Proteomic databases

EPDiQ8K0D0
PaxDbiQ8K0D0
PRIDEiQ8K0D0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069965; ENSMUSP00000070355; ENSMUSG00000020015 [Q8K0D0-1]
GeneIDi237459
KEGGimmu:237459
UCSCiuc007gul.2 mouse [Q8K0D0-1]

Organism-specific databases

CTDi5128
MGIiMGI:97517 Cdk17

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00900000140869
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ8K0D0
KOiK15595
OrthoDBiEOG091G0CH0
PhylomeDBiQ8K0D0
TreeFamiTF106508

Miscellaneous databases

ChiTaRSiCdk17 mouse
PROiPR:Q8K0D0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020015 Expressed in 241 organ(s), highest expression level in olfactory tubercle
CleanExiMM_PCTK2
ExpressionAtlasiQ8K0D0 baseline and differential
GenevisibleiQ8K0D0 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK17_MOUSE
AccessioniPrimary (citable) accession number: Q8K0D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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