UniProtKB - Q8K0B2 (LMBD1_MOUSE)

BLAST

>sp|Q8K0B2|LMBD1_MOUSE Probable lysosomal cobalamin transporter OS=Mus musculus OX=10090 GN=Lmbrd1 PE=1 SV=1
MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSAL
LPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYY
EEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFED
LGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEE
VEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRP
LKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVF
PLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLH
TSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIF
LHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA

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History
Entry version 114 (07 Nov 2018)
Sequence version 1 (01 Oct 2002)
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Protein

Probable lysosomal cobalamin transporter

Gene

Lmbrd1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).By similarity

GO - Molecular functionⁱ

cobalamin binding Source: UniProtKB-KW
insulin receptor binding
Source: MGI
Inferred from direct assayⁱ
- 24078630

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

insulin receptor internalization
Source: MGI
Inferred from mutant phenotypeⁱ
- 24078630
negative regulation of glucose import
Source: MGI
Inferred from mutant phenotypeⁱ
- 24078630
negative regulation of insulin receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 24078630
negative regulation of protein kinase B signaling
Source: MGI
Inferred from mutant phenotypeⁱ
- 24078630

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Cobalamin, Cobalt

Enzyme and pathway databases

Reactomeⁱ	R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Reactomeⁱ

R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable lysosomal cobalamin transporter Alternative name(s): LMBR1 domain-containing protein 1 Protein N90b
Gene namesⁱ	Name:Lmbrd1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1915671 Lmbrd1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	ExtracellularSequence analysis	7
Transmembraneⁱ	8 – 28	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	29 – 47	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	48 – 68	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	69 – 97	ExtracellularSequence analysisAdd BLAST	29
Transmembraneⁱ	98 – 118	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 141	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 185	ExtracellularSequence analysisAdd BLAST	23
Transmembraneⁱ	186 – 206	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	207 – 302	CytoplasmicSequence analysisAdd BLAST	96
Transmembraneⁱ	303 – 323	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	324 – 361	ExtracellularSequence analysisAdd BLAST	38
Transmembraneⁱ	362 – 382	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	383 – 405	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	406 – 426	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	427 – 483	ExtracellularSequence analysisAdd BLAST	57
Transmembraneⁱ	484 – 504	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	505 – 537	CytoplasmicSequence analysisAdd BLAST	33

Keywords - Cellular componentⁱ

Lysosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000260517	1 – 537	Probable lysosomal cobalamin transporterAdd BLAST		537

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	85	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	235	PhosphothreonineCombined sources	1
Glycosylationⁱ	344	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	445	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	454	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	525	PhosphoserineCombined sources	1
Modified residueⁱ	528	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8K0B2
PeptideAtlas More...PeptideAtlasⁱ	Q8K0B2
PRIDEⁱ	Q8K0B2

PTM databases

iPTMnetⁱ	Q8K0B2
PhosphoSitePlusⁱ	Q8K0B2
SwissPalmⁱ	Q8K0B2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000073725 Expressed in 271 organ(s), highest expression level in saccule of membranous labyrinth
CleanExⁱ	MM_LMBRD1
ExpressionAtlasⁱ	Q8K0B2 baseline and differential
Genevisibleⁱ	Q8K0B2 MM

Interactionⁱ

GO - Molecular functionⁱ

insulin receptor binding
Source: MGI
Inferred from direct assayⁱ
- 24078630

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000092672

STRINGⁱ

10090.ENSMUSP00000092672

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LIMR family. LMBRD1 subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFHV Eukaryota ENOG410XPKG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002581
HOGENOMⁱ	HOG000068018
HOVERGENⁱ	HBG059142
InParanoidⁱ	Q8K0B2
KEGG Orthology (KO) More...KOⁱ	K14617
OMAⁱ	LNVPNNK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BP6
PhylomeDBⁱ	Q8K0B2
TreeFamⁱ	TF329170

Family and domain databases

InterProⁱ	View protein in InterPro IPR006876 LMBR1-like_membr_prot
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04791 LMBR1, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8K0B2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAELVI GWCIFGLLLL AILAFCWVYV RKYQSQRESE VVSTVTAIFS 
        60         70         80         90        100
LAVALITSAL LPVDIFLVSY MKNQNGTFKD WADANVTVQI ENTVLYGYYT 
       110        120        130        140        150
LYSVILFCVF FWIPFVYFYY EEKDEDDASK CTQIKTALKY TLGFVVICAL 
       160        170        180        190        200
LLLVGAFVPL HLPNNNNSTE WEKVKLLFED LGTGQGLAAL SFSISSLTLI 
       210        220        230        240        250
GMLAAITYTA YGMSALPLNL IKGTRSTAYE RLENTEDIEE VEQHIQTIRS 
       260        270        280        290        300
KSKDGRPLPA RDRRALKQCE ERLRTLRKRE RHLEFIENSW WTKFCGALRP 
       310        320        330        340        350
LKIIWGIFFI LVALLFVISL FLSNLDKALH SAGIDSGFII FGTNLSNPLN 
       360        370        380        390        400
MLLPLLQTVF PLDYILITII IMYFIFTSMA GIRNIGIWFF WIRLYKIRRG 
       410        420        430        440        450
RTRPQALLFL CMILLLIVLH TSYMIYSLAP QYVMYGSQNY LIESNITSDA 
       460        470        480        490        500
HKGNSTLAVP KRCDADAPKD QCTVTRTYIF LHKFWFFSAA YYFGNWAFLV 
       510        520        530 
VFLIGLIVSC CKGKKSVIEG VDEDSDLSDD EPSAYSA

Length:537

Mass (Da):61,062

Last modified:October 1, 2002 - v1

Checksum:ⁱ7AAFF431479752F0

Isoform 2 (identifier: Q8K0B2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-18: Missing.
19-20: LL → MQ

« Hide

        10         20         30         40         50
MQAILAFCWV YVRKYQSQRE SEVVSTVTAI FSLAVALITS ALLPVDIFLV 
        60         70         80         90        100
SYMKNQNGTF KDWADANVTV QIENTVLYGY YTLYSVILFC VFFWIPFVYF 
       110        120        130        140        150
YYEEKDEDDA SKCTQIKTAL KYTLGFVVIC ALLLLVGAFV PLHLPNNNNS 
       160        170        180        190        200
TEWEKVKLLF EDLGTGQGLA ALSFSISSLT LIGMLAAITY TAYGMSALPL 
       210        220        230        240        250
NLIKGTRSTA YERLENTEDI EEVEQHIQTI RSKSKDGRPL PARDRRALKQ 
       260        270        280        290        300
CEERLRTLRK RERHLEFIEN SWWTKFCGAL RPLKIIWGIF FILVALLFVI 
       310        320        330        340        350
SLFLSNLDKA LHSAGIDSGF IIFGTNLSNP LNMLLPLLQT VFPLDYILIT 
       360        370        380        390        400
IIIMYFIFTS MAGIRNIGIW FFWIRLYKIR RGRTRPQALL FLCMILLLIV 
       410        420        430        440        450
LHTSYMIYSL APQYVMYGSQ NYLIESNITS DAHKGNSTLA VPKRCDADAP 
       460        470        480        490        500
KDQCTVTRTY IFLHKFWFFS AAYYFGNWAF LVVFLIGLIV SCCKGKKSVI 
       510 
EGVDEDSDLS DDEPSAYSA

Note: No experimental confirmation available.

Show »

Length:519

Mass (Da):59,264

Checksum:ⁱ5F1EB67EA4D94D32

Isoform 3 (identifier: Q8K0B2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-70: Missing.

« Hide

        10         20         30         40         50
MKNQNGTFKD WADANVTVQI ENTVLYGYYT LYSVILFCVF FWIPFVYFYY 
        60         70         80         90        100
EEKDEDDASK CTQIKTALKY TLGFVVICAL LLLVGAFVPL HLPNNNNSTE 
       110        120        130        140        150
WEKVKLLFED LGTGQGLAAL SFSISSLTLI GMLAAITYTA YGMSALPLNL 
       160        170        180        190        200
IKGTRSTAYE RLENTEDIEE VEQHIQTIRS KSKDGRPLPA RDRRALKQCE 
       210        220        230        240        250
ERLRTLRKRE RHLEFIENSW WTKFCGALRP LKIIWGIFFI LVALLFVISL 
       260        270        280        290        300
FLSNLDKALH SAGIDSGFII FGTNLSNPLN MLLPLLQTVF PLDYILITII 
       310        320        330        340        350
IMYFIFTSMA GIRNIGIWFF WIRLYKIRRG RTRPQALLFL CMILLLIVLH 
       360        370        380        390        400
TSYMIYSLAP QYVMYGSQNY LIESNITSDA HKGNSTLAVP KRCDADAPKD 
       410        420        430        440        450
QCTVTRTYIF LHKFWFFSAA YYFGNWAFLV VFLIGLIVSC CKGKKSVIEG 
       460 
VDEDSDLSDD EPSAYSA

Show »

Length:467

Mass (Da):53,440

Checksum:ⁱBC4647DF0C55E55A

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WPS2	A0A087WPS2_MOUSE	Probable lysosomal cobalamin transp... Probable lysosomal cobalamin transporter	Lmbrd1	143	Annotation score:
A0A087WS60	A0A087WS60_MOUSE	Probable lysosomal cobalamin transp... Probable lysosomal cobalamin transporter	Lmbrd1	161	Annotation score:
A0A087WR85	A0A087WR85_MOUSE	Probable lysosomal cobalamin transp... Probable lysosomal cobalamin transporter	Lmbrd1	143	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	62	P → L in BAC27926 (PubMed:16141072).Curated	1
Sequence conflictⁱ	173	K → Q in AAL38052 (Ref. 1) Curated	1
Sequence conflictⁱ	193	S → P in AAL38052 (Ref. 1) Curated	1
Sequence conflictⁱ	386	G → D in BAE31002 (PubMed:16141072).Curated	1
Sequence conflictⁱ	386	G → D in BAE31829 (PubMed:16141072).Curated	1
Sequence conflictⁱ	496	W → R in BAB22556 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_021631	1 – 70	Missing in isoform 3. 3 PublicationsAdd BLAST	70
Alternative sequenceⁱVSP_021632	1 – 18	Missing in isoform 2. 1 PublicationAdd BLAST	18
Alternative sequenceⁱVSP_021633	19 – 20	LL → MQ in isoform 2. 1 Publication	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY061989 mRNA Translation: AAL38052.1 AK003084 mRNA Translation: BAB22556.1 AK032560 mRNA Translation: BAC27926.1 AK152170 mRNA Translation: BAE31002.1 AK153237 mRNA Translation: BAE31829.1 AK158982 mRNA Translation: BAE34756.1 AK167080 mRNA Translation: BAE39240.1 BC025579 mRNA Translation: AAH25579.1 BC027774 mRNA Translation: AAH27774.1 BC031902 mRNA Translation: AAH31902.1 BC039053 mRNA Translation: AAH39053.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35528.1 [Q8K0B2-1] CCDS78556.1 [Q8K0B2-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001297412.1, NM_001310483.1 [Q8K0B2-3] NP_080995.2, NM_026719.2 [Q8K0B2-1]
UniGeneⁱ	Mm.336563

Genome annotation databases

Ensemblⁱ	ENSMUST00000095062; ENSMUSP00000092672; ENSMUSG00000073725 [Q8K0B2-3] ENSMUST00000191471; ENSMUSP00000140783; ENSMUSG00000073725 [Q8K0B2-1]
GeneIDⁱ	68421
KEGGⁱ	mmu:68421
UCSC genome browser More...UCSCⁱ	uc007amt.1 mouse [Q8K0B2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K0B2	Probable lysosomal cobalamin transporter		RAT		537	UniRef90_Q8K0B2
Isoform 3 of Probable lysosomal cobalamin transporter		MOUSE		467
Uncharacterized protein		PAPAN		542
LMBR1 domain containing 1		CANLF		540
Uncharacterized protein		MACMU		540
+21
Q8K0B2-2	Probable lysosomal cobalamin transporter		HUMAN		540	UniRef90_Q9NUN5
Probable lysosomal cobalamin transporter		MACFA		540
Uncharacterized protein		PIG		552
probable lysosomal cobalamin transporter		ERIEU		545
probable lysosomal cobalamin transporter		TARSY		545
+87

Protein	Similar proteins		Species	Score	Length	Source
Q8K0B2	Probable lysosomal cobalamin transporter		HUMAN		540	UniRef50_Q9NUN5
Probable lysosomal cobalamin transporter		MACFA		540
Probable lysosomal cobalamin transporter		DANRE		541
Probable lysosomal cobalamin transporter		CHICK		539
Probable lysosomal cobalamin transporter		XENLA		537
+372

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY061989 mRNA Translation: AAL38052.1 AK003084 mRNA Translation: BAB22556.1 AK032560 mRNA Translation: BAC27926.1 AK152170 mRNA Translation: BAE31002.1 AK153237 mRNA Translation: BAE31829.1 AK158982 mRNA Translation: BAE34756.1 AK167080 mRNA Translation: BAE39240.1 BC025579 mRNA Translation: AAH25579.1 BC027774 mRNA Translation: AAH27774.1 BC031902 mRNA Translation: AAH31902.1 BC039053 mRNA Translation: AAH39053.1
CCDSⁱ	CCDS35528.1 [Q8K0B2-1] CCDS78556.1 [Q8K0B2-3]
RefSeqⁱ	NP_001297412.1, NM_001310483.1 [Q8K0B2-3] NP_080995.2, NM_026719.2 [Q8K0B2-1]
UniGeneⁱ	Mm.336563

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000092672

STRINGⁱ

10090.ENSMUSP00000092672

PTM databases

iPTMnetⁱ	Q8K0B2
PhosphoSitePlusⁱ	Q8K0B2
SwissPalmⁱ	Q8K0B2

Proteomic databases

PaxDbⁱ	Q8K0B2
PeptideAtlasⁱ	Q8K0B2
PRIDEⁱ	Q8K0B2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000095062; ENSMUSP00000092672; ENSMUSG00000073725 [Q8K0B2-3] ENSMUST00000191471; ENSMUSP00000140783; ENSMUSG00000073725 [Q8K0B2-1]
GeneIDⁱ	68421
KEGGⁱ	mmu:68421
UCSCⁱ	uc007amt.1 mouse [Q8K0B2-1]

Organism-specific databases

CTDⁱ	55788
MGIⁱ	MGI:1915671 Lmbrd1

Phylogenomic databases

eggNOGⁱ	ENOG410IFHV Eukaryota ENOG410XPKG LUCA
GeneTreeⁱ	ENSGT00390000002581
HOGENOMⁱ	HOG000068018
HOVERGENⁱ	HBG059142
InParanoidⁱ	Q8K0B2
KOⁱ	K14617
OMAⁱ	LNVPNNK
OrthoDBⁱ	EOG091G0BP6
PhylomeDBⁱ	Q8K0B2
TreeFamⁱ	TF329170

Enzyme and pathway databases

Reactomeⁱ	R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Reactomeⁱ

R-MMU-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8K0B2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000073725 Expressed in 271 organ(s), highest expression level in saccule of membranous labyrinth
CleanExⁱ	MM_LMBRD1
ExpressionAtlasⁱ	Q8K0B2 baseline and differential
Genevisibleⁱ	Q8K0B2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006876 LMBR1-like_membr_prot
Pfamⁱ	View protein in Pfam PF04791 LMBR1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LMBD1_MOUSE
Accessionⁱ	Q8K0B2Primary (citable) accession number: Q8K0B2 Secondary accession number(s): Q3U696 , Q8CCL7, Q8R3D6, Q8VH50, Q9CW67
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K0B2 (LMBD1_MOUSE)

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Probable lysosomal cobalamin transporter

Lmbrd1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ