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Protein

Zinc finger and BTB domain-containing protein 6

Gene

Zbtb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri300 – 322C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 404C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 6
Alternative name(s):
Zinc finger protein 482
Gene namesi
Name:Zbtb6
Synonyms:Zfp482, Znf482
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2442998 Zbtb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476091 – 423Zinc finger and BTB domain-containing protein 6Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K088
PRIDEiQ8K088

PTM databases

iPTMnetiQ8K088
PhosphoSitePlusiQ8K088

Expressioni

Gene expression databases

BgeeiENSMUSG00000066798 Expressed in 240 organ(s), highest expression level in embryo
CleanExiMM_ZBTB6
GenevisibleiQ8K088 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056100

Structurei

3D structure databases

ProteinModelPortaliQ8K088
SMRiQ8K088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri300 – 322C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 404C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ8K088
KOiK10493
OMAiGQGLFCE
OrthoDBiEOG091G04SQ
PhylomeDBiQ8K088
TreeFamiTF333162

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q8K088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GWKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNQHTD LCQSSDTDVK
160 170 180 190 200
NEEENSDKDC EIIEISEDSP VNLDFHVKEE ESNALQSAAE TLTSERMRMQ
210 220 230 240 250
SPELSAVDGG FKENEICILH VESISTDDVE NGQFSQPCTS SKAGIYFPET
260 270 280 290 300
QHSLINSTVE NRVTEVPGNT NQGLFSENSD GSHGTVNEIQ NLDENFSLRH
310 320 330 340 350
QCPRCPRGFL HVENYLRHLK MHKLFLCLQC GKTFTQKKNL NRHIRGHMGI
360 370 380 390 400
RPFQCTVCLK TFTAKSTLQD HLNIHSGDRP YKCHCCDMDF KHKSALKKHL
410 420
TSVHGRSSGE KLSRPDLKRQ NLL
Length:423
Mass (Da):48,188
Last modified:October 1, 2002 - v1
Checksum:i85C9CCF7B2309C1B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti397K → E in BAC31788 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044125 mRNA Translation: BAC31788.1
AK050827 mRNA Translation: BAC34426.1
AK053443 mRNA Translation: BAC35387.1
AL953890 Genomic DNA No translation available.
BC032933 mRNA Translation: AAH32933.1
CCDSiCCDS16000.1
RefSeqiNP_666365.1, NM_146253.5
UniGeneiMm.330182

Genome annotation databases

EnsembliENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798
ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798
GeneIDi241322
KEGGimmu:241322
UCSCiuc008jms.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044125 mRNA Translation: BAC31788.1
AK050827 mRNA Translation: BAC34426.1
AK053443 mRNA Translation: BAC35387.1
AL953890 Genomic DNA No translation available.
BC032933 mRNA Translation: AAH32933.1
CCDSiCCDS16000.1
RefSeqiNP_666365.1, NM_146253.5
UniGeneiMm.330182

3D structure databases

ProteinModelPortaliQ8K088
SMRiQ8K088
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056100

PTM databases

iPTMnetiQ8K088
PhosphoSitePlusiQ8K088

Proteomic databases

PaxDbiQ8K088
PRIDEiQ8K088

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798
ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798
GeneIDi241322
KEGGimmu:241322
UCSCiuc008jms.2 mouse

Organism-specific databases

CTDi10773
MGIiMGI:2442998 Zbtb6

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000232051
HOVERGENiHBG056199
InParanoidiQ8K088
KOiK10493
OMAiGQGLFCE
OrthoDBiEOG091G04SQ
PhylomeDBiQ8K088
TreeFamiTF333162

Miscellaneous databases

PROiPR:Q8K088
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066798 Expressed in 240 organ(s), highest expression level in embryo
CleanExiMM_ZBTB6
GenevisibleiQ8K088 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB6_MOUSE
AccessioniPrimary (citable) accession number: Q8K088
Secondary accession number(s): A2AWA4, Q8BLM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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