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UniProtKB - Q8K088 (ZBTB6_MOUSE)
Protein
Zinc finger and BTB domain-containing protein 6
Gene
Zbtb6
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 300 – 322 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 404 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 6Alternative name(s): Zinc finger protein 482 |
Gene namesi | Name:Zbtb6 Synonyms:Zfp482, Znf482 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442998, Zbtb6 |
VEuPathDBi | HostDB:ENSMUSG00000066798 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047609 | 1 – 423 | Zinc finger and BTB domain-containing protein 6Add BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 201 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q8K088 |
PRIDEi | Q8K088 |
ProteomicsDBi | 302040 |
PTM databases
iPTMneti | Q8K088 |
PhosphoSitePlusi | Q8K088 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000066798, Expressed in embryo and 263 other tissues |
Genevisiblei | Q8K088, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 232307, 3 interactors |
STRINGi | 10090.ENSMUSP00000108554 |
Miscellaneous databases
RNActi | Q8K088, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 97 | BTBPROSITE-ProRule annotationAdd BLAST | 65 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 300 – 322 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 404 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161459 |
HOGENOMi | CLU_037856_1_0_1 |
InParanoidi | Q8K088 |
OMAi | FRMDSMN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8K088 |
TreeFami | TF333162 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q8K088-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI
60 70 80 90 100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GWKLLLSCYT GALEVKRKEL
110 120 130 140 150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNQHTD LCQSSDTDVK
160 170 180 190 200
NEEENSDKDC EIIEISEDSP VNLDFHVKEE ESNALQSAAE TLTSERMRMQ
210 220 230 240 250
SPELSAVDGG FKENEICILH VESISTDDVE NGQFSQPCTS SKAGIYFPET
260 270 280 290 300
QHSLINSTVE NRVTEVPGNT NQGLFSENSD GSHGTVNEIQ NLDENFSLRH
310 320 330 340 350
QCPRCPRGFL HVENYLRHLK MHKLFLCLQC GKTFTQKKNL NRHIRGHMGI
360 370 380 390 400
RPFQCTVCLK TFTAKSTLQD HLNIHSGDRP YKCHCCDMDF KHKSALKKHL
410 420
TSVHGRSSGE KLSRPDLKRQ NLL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 397 | K → E in BAC31788 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK044125 mRNA Translation: BAC31788.1 AK050827 mRNA Translation: BAC34426.1 AK053443 mRNA Translation: BAC35387.1 AL953890 Genomic DNA No translation available. BC032933 mRNA Translation: AAH32933.1 |
CCDSi | CCDS16000.1 |
RefSeqi | NP_666365.1, NM_146253.5 |
Genome annotation databases
Ensembli | ENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798 ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798 |
GeneIDi | 241322 |
KEGGi | mmu:241322 |
UCSCi | uc008jms.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK044125 mRNA Translation: BAC31788.1 AK050827 mRNA Translation: BAC34426.1 AK053443 mRNA Translation: BAC35387.1 AL953890 Genomic DNA No translation available. BC032933 mRNA Translation: AAH32933.1 |
CCDSi | CCDS16000.1 |
RefSeqi | NP_666365.1, NM_146253.5 |
3D structure databases
AlphaFoldDBi | Q8K088 |
SMRi | Q8K088 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232307, 3 interactors |
STRINGi | 10090.ENSMUSP00000108554 |
PTM databases
iPTMneti | Q8K088 |
PhosphoSitePlusi | Q8K088 |
Proteomic databases
PaxDbi | Q8K088 |
PRIDEi | Q8K088 |
ProteomicsDBi | 302040 |
Protocols and materials databases
Antibodypediai | 30390, 228 antibodies from 27 providers |
DNASUi | 241322 |
Genome annotation databases
Ensembli | ENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798 ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798 |
GeneIDi | 241322 |
KEGGi | mmu:241322 |
UCSCi | uc008jms.2, mouse |
Organism-specific databases
CTDi | 10773 |
MGIi | MGI:2442998, Zbtb6 |
VEuPathDBi | HostDB:ENSMUSG00000066798 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161459 |
HOGENOMi | CLU_037856_1_0_1 |
InParanoidi | Q8K088 |
OMAi | FRMDSMN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8K088 |
TreeFami | TF333162 |
Miscellaneous databases
BioGRID-ORCSi | 241322, 2 hits in 73 CRISPR screens |
ChiTaRSi | Zbtb6, mouse |
PROi | PR:Q8K088 |
RNActi | Q8K088, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000066798, Expressed in embryo and 263 other tissues |
Genevisiblei | Q8K088, MM |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBTB6_MOUSE | |
Accessioni | Q8K088Primary (citable) accession number: Q8K088 Secondary accession number(s): A2AWA4, Q8BLM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot