Zbtb6

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	300 – 322	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	325 – 347	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	353 – 375	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	381 – 404	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 6 Alternative name(s): Zinc finger protein 482
Gene namesⁱ	Name:Zbtb6 Synonyms:Zfp482, Znf482
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:2442998 Zbtb6

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047609	1 – 423	Zinc finger and BTB domain-containing protein 6Add BLAST		423

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	201	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8K088
PRIDEⁱ	Q8K088

PTM databases

iPTMnetⁱ	Q8K088
PhosphoSitePlusⁱ	Q8K088

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000066798 Expressed in 240 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZBTB6
Genevisibleⁱ	Q8K088 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000056100

STRINGⁱ

10090.ENSMUSP00000056100

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8K088
SMRⁱ	Q8K088
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 97	BTBPROSITE-ProRule annotationAdd BLAST		65

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	300 – 322	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	325 – 347	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	353 – 375	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	381 – 404	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119063
HOGENOMⁱ	HOG000232051
HOVERGENⁱ	HBG056199
InParanoidⁱ	Q8K088
KEGG Orthology (KO) More...KOⁱ	K10493
OMAⁱ	GQGLFCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04SQ
PhylomeDBⁱ	Q8K088
TreeFamⁱ	TF333162

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8K088-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI 
        60         70         80         90        100
LAACSTFMRD QFLLTQSKHV RITILQSAEV GWKLLLSCYT GALEVKRKEL 
       110        120        130        140        150
LKYLTAASYL QMVHIVEKCT EALSKYLEID LSMKNNQHTD LCQSSDTDVK 
       160        170        180        190        200
NEEENSDKDC EIIEISEDSP VNLDFHVKEE ESNALQSAAE TLTSERMRMQ 
       210        220        230        240        250
SPELSAVDGG FKENEICILH VESISTDDVE NGQFSQPCTS SKAGIYFPET 
       260        270        280        290        300
QHSLINSTVE NRVTEVPGNT NQGLFSENSD GSHGTVNEIQ NLDENFSLRH 
       310        320        330        340        350
QCPRCPRGFL HVENYLRHLK MHKLFLCLQC GKTFTQKKNL NRHIRGHMGI 
       360        370        380        390        400
RPFQCTVCLK TFTAKSTLQD HLNIHSGDRP YKCHCCDMDF KHKSALKKHL 
       410        420 
TSVHGRSSGE KLSRPDLKRQ NLL

Length:423

Mass (Da):48,188

Last modified:October 1, 2002 - v1

Checksum:ⁱ85C9CCF7B2309C1B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	397	K → E in BAC31788 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK044125 mRNA Translation: BAC31788.1 AK050827 mRNA Translation: BAC34426.1 AK053443 mRNA Translation: BAC35387.1 AL953890 Genomic DNA No translation available. BC032933 mRNA Translation: AAH32933.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16000.1
NCBI Reference Sequences More...RefSeqⁱ	NP_666365.1, NM_146253.5
UniGeneⁱ	Mm.330182

Genome annotation databases

Ensemblⁱ	ENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798 ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798
GeneIDⁱ	241322
KEGGⁱ	mmu:241322
UCSC genome browser More...UCSCⁱ	uc008jms.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8K088	Zinc finger and BTB domain-containing protein 6		HUMAN		424	UniRef90_Q15916
Zinc finger and BTB domain-containing protein 6		BOVIN		424
ZBTB6 isoform 1		PANTR		424
Uncharacterized protein		PANPA		424
Uncharacterized protein		NOMLE		424
+114

Protein	Similar proteins		Species	Score	Length	Source
Q8K088	Zinc finger and BTB domain-containing protein 6		HUMAN		424	UniRef50_Q15916
Zinc finger and BTB domain-containing protein 6		BOVIN		424
ZBTB6 isoform 1		PANTR		424
Uncharacterized protein		PANPA		424
Uncharacterized protein		NOMLE		424
+221

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK044125 mRNA Translation: BAC31788.1 AK050827 mRNA Translation: BAC34426.1 AK053443 mRNA Translation: BAC35387.1 AL953890 Genomic DNA No translation available. BC032933 mRNA Translation: AAH32933.1
CCDSⁱ	CCDS16000.1
RefSeqⁱ	NP_666365.1, NM_146253.5
UniGeneⁱ	Mm.330182

3D structure databases

ProteinModelPortalⁱ	Q8K088
SMRⁱ	Q8K088
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000056100

STRINGⁱ

10090.ENSMUSP00000056100

PTM databases

iPTMnetⁱ	Q8K088
PhosphoSitePlusⁱ	Q8K088

Proteomic databases

PaxDbⁱ	Q8K088
PRIDEⁱ	Q8K088

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000053098; ENSMUSP00000056100; ENSMUSG00000066798 ENSMUST00000112932; ENSMUSP00000108554; ENSMUSG00000066798
GeneIDⁱ	241322
KEGGⁱ	mmu:241322
UCSCⁱ	uc008jms.2 mouse

Organism-specific databases

CTDⁱ	10773
MGIⁱ	MGI:2442998 Zbtb6

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000119063
HOGENOMⁱ	HOG000232051
HOVERGENⁱ	HBG056199
InParanoidⁱ	Q8K088
KOⁱ	K10493
OMAⁱ	GQGLFCE
OrthoDBⁱ	EOG091G04SQ
PhylomeDBⁱ	Q8K088
TreeFamⁱ	TF333162

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8K088
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000066798 Expressed in 240 organ(s), highest expression level in embryo
CleanExⁱ	MM_ZBTB6
Genevisibleⁱ	Q8K088 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBTB6_MOUSE
Accessionⁱ	Q8K088Primary (citable) accession number: Q8K088 Secondary accession number(s): A2AWA4, Q8BLM4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
	Last sequence update:	October 1, 2002
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8K088 (ZBTB6_MOUSE)

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Zinc finger and BTB domain-containing protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ