UniProtKB - Q8K087 (GPR1_MOUSE)
Protein
G-protein coupled receptor 1
Gene
Gpr1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (PubMed:29799787).By similarity1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- neuropeptide signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 1 |
Gene namesi | Name:Gpr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385324, Gpr1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Internalizes in presence of its ligand, TAFA1.1 Publication
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 73 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 74 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 112 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 154 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 210 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 211 – 231 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 247 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 248 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 286 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 287 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 353 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069508 | 1 – 353 | G-protein coupled receptor 1Add BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8K087 |
PRIDEi | Q8K087 |
PTM databases
GlyGeni | Q8K087, 1 site |
PhosphoSitePlusi | Q8K087 |
Expressioni
Tissue specificityi
Expressed in hippocampus and cortex.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000046856, Expressed in oocyte and 75 other tissues |
Genevisiblei | Q8K087, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051417 |
Miscellaneous databases
RNActi | Q8K087, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160642 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | Q8K087 |
OMAi | SSCYLCL |
OrthoDBi | 910274at2759 |
PhylomeDBi | Q8K087 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8K087-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVSKEMLFE ELDNYSYALD YYSQESDPEE KVYLGLVHWI SLFLYALAFV
60 70 80 90 100
LGIPGNAIVI WLMGFKWKKT VTTLWFLNLA IADFIFVLFL PLYISYVALS
110 120 130 140 150
FHWPFGLWLC KVNSFIAQLN MFSSVFFLTV ISLDRYIHLL HPGLSHRHRT
160 170 180 190 200
LKSSLVVVIL VWLLASLLGG PTLYFRDTME VNNHIICYNN FQEHELTLMR
210 220 230 240 250
HHVLTWVKFL FGYLFPLLTM SSCYLCLIFK MKKRNILISR KHLWMILSVV
260 270 280 290 300
IAFLVCWTPY HLFSIWELSI HHNSSFQNVL QGGIPLSTGL AFLNSCLNPI
310 320 330 340 350
LYVLISKTFQ ARFRASVAEV LKRSLWEASC SGTVSEQLRS AETKSLSLLE
TAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL645950 Genomic DNA No translation available. BC032934 mRNA Translation: AAH32934.1 |
CCDSi | CCDS14998.1 |
RefSeqi | NP_666362.1, NM_146250.2 XP_006496043.1, XM_006495980.2 XP_006496044.1, XM_006495981.2 XP_011236820.1, XM_011238518.2 XP_011236821.1, XM_011238519.2 |
Genome annotation databases
Ensembli | ENSMUST00000050536; ENSMUSP00000051417; ENSMUSG00000046856 |
GeneIDi | 241070 |
KEGGi | mmu:241070 |
UCSCi | uc007bga.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL645950 Genomic DNA No translation available. BC032934 mRNA Translation: AAH32934.1 |
CCDSi | CCDS14998.1 |
RefSeqi | NP_666362.1, NM_146250.2 XP_006496043.1, XM_006495980.2 XP_006496044.1, XM_006495981.2 XP_011236820.1, XM_011238518.2 XP_011236821.1, XM_011238519.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000051417 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8K087, 1 site |
PhosphoSitePlusi | Q8K087 |
Proteomic databases
PaxDbi | Q8K087 |
PRIDEi | Q8K087 |
Protocols and materials databases
Antibodypediai | 1410, 229 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000050536; ENSMUSP00000051417; ENSMUSG00000046856 |
GeneIDi | 241070 |
KEGGi | mmu:241070 |
UCSCi | uc007bga.3, mouse |
Organism-specific databases
CTDi | 2825 |
MGIi | MGI:2385324, Gpr1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160642 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | Q8K087 |
OMAi | SSCYLCL |
OrthoDBi | 910274at2759 |
PhylomeDBi | Q8K087 |
TreeFami | TF330976 |
Miscellaneous databases
BioGRID-ORCSi | 241070, 1 hit in 17 CRISPR screens |
ChiTaRSi | Gpr1, mouse |
PROi | PR:Q8K087 |
RNActi | Q8K087, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046856, Expressed in oocyte and 75 other tissues |
Genevisiblei | Q8K087, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR1_MOUSE | |
Accessioni | Q8K087Primary (citable) accession number: Q8K087 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries