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Protein

GSK-3-binding protein FRAT2

Gene

Frat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

GO - Biological processi

  • Wnt signaling pathway Source: MGI

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Names & Taxonomyi

Protein namesi
Recommended name:
GSK-3-binding protein FRAT2
Alternative name(s):
Frequently rearranged in advanced T-cell lymphomas 2
Short name:
FRAT-2
Gene namesi
Name:Frat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2673967 Frat2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873351 – 231GSK-3-binding protein FRAT2Add BLAST231

Proteomic databases

PaxDbiQ8K025
PRIDEiQ8K025

PTM databases

PhosphoSitePlusiQ8K025

Expressioni

Gene expression databases

BgeeiENSMUSG00000047604 Expressed in 196 organ(s), highest expression level in retina
GenevisibleiQ8K025 MM

Interactioni

Subunit structurei

Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

Protein-protein interaction databases

ComplexPortaliCPX-110 Nuclear export complex Frat2-Gsk3b
STRINGi10090.ENSMUSP00000052788

Structurei

3D structure databases

ProteinModelPortaliQ8K025
SMRiQ8K025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 194Involved in GSK-3 bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 22Asp/Glu-rich (highly acidic)Add BLAST17
Compositional biasi6 – 10Poly-Glu5

Sequence similaritiesi

Belongs to the GSK-3-binding protein family.Curated

Phylogenomic databases

eggNOGiENOG410J5HI Eukaryota
ENOG410ZA2I LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiQ8K025
KOiK03096
OMAiQRRWTQA
OrthoDBiEOG091G0PDL
PhylomeDBiQ8K025
TreeFamiTF330804

Family and domain databases

InterProiView protein in InterPro
IPR039202 FRAT2
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PTHR35154:SF2 PTHR35154:SF2, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 2 hits

Sequencei

Sequence statusi: Complete.

Q8K025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRREEEEE AGDEAEGEED DDSFLLLQQS VTLGGSTDVD RLIVQIGETL
60 70 80 90 100
QLDTAHDRPA SPCAAPGPPP APPRVLAALS ADKTGTPARR LLRPTGSAET
110 120 130 140 150
GDPAPPGAVR CVLGERGRVR GRSAPYCVAE IAPGASALPG PGRRGWLPGS
160 170 180 190 200
VASHRIQQRR WTAGGARAAD DDPHRLLQQL VLSGNLIKEA VRRLQRAVAA
210 220 230
VAATSPASAP GSGGGRSGPD SVTLQPSGAW L
Length:231
Mass (Da):23,914
Last modified:October 1, 2002 - v1
Checksum:i6C2C0164B9476C37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518895 Genomic DNA Translation: AAR99812.1
AK081171 mRNA Translation: BAC38155.1
BC034214 mRNA Translation: AAH34214.1
BC085510 mRNA Translation: AAH85510.1
CCDSiCCDS29813.1
RefSeqiNP_808271.1, NM_177603.3
UniGeneiMm.222723

Genome annotation databases

EnsembliENSMUST00000059231; ENSMUSP00000052788; ENSMUSG00000047604
GeneIDi212398
KEGGimmu:212398
UCSCiuc008hmj.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518895 Genomic DNA Translation: AAR99812.1
AK081171 mRNA Translation: BAC38155.1
BC034214 mRNA Translation: AAH34214.1
BC085510 mRNA Translation: AAH85510.1
CCDSiCCDS29813.1
RefSeqiNP_808271.1, NM_177603.3
UniGeneiMm.222723

3D structure databases

ProteinModelPortaliQ8K025
SMRiQ8K025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-110 Nuclear export complex Frat2-Gsk3b
STRINGi10090.ENSMUSP00000052788

PTM databases

PhosphoSitePlusiQ8K025

Proteomic databases

PaxDbiQ8K025
PRIDEiQ8K025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059231; ENSMUSP00000052788; ENSMUSG00000047604
GeneIDi212398
KEGGimmu:212398
UCSCiuc008hmj.3 mouse

Organism-specific databases

CTDi23401
MGIiMGI:2673967 Frat2

Phylogenomic databases

eggNOGiENOG410J5HI Eukaryota
ENOG410ZA2I LUCA
GeneTreeiENSGT00390000007081
HOGENOMiHOG000112642
HOVERGENiHBG051660
InParanoidiQ8K025
KOiK03096
OMAiQRRWTQA
OrthoDBiEOG091G0PDL
PhylomeDBiQ8K025
TreeFamiTF330804

Enzyme and pathway databases

ReactomeiR-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Miscellaneous databases

ChiTaRSiFrat2 mouse
PROiPR:Q8K025
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047604 Expressed in 196 organ(s), highest expression level in retina
GenevisibleiQ8K025 MM

Family and domain databases

InterProiView protein in InterPro
IPR039202 FRAT2
IPR008014 GSK3-bd
PANTHERiPTHR35154 PTHR35154, 1 hit
PTHR35154:SF2 PTHR35154:SF2, 1 hit
PfamiView protein in Pfam
PF05350 GSK-3_bind, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFRAT2_MOUSE
AccessioniPrimary (citable) accession number: Q8K025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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