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Protein

Secretory carrier-associated membrane protein 1

Gene

Scamp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • endocytosis Source: MGI
  • exocytosis Source: MGI
  • protein transport Source: UniProtKB

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretory carrier-associated membrane protein 1
Short name:
Secretory carrier membrane protein 1
Gene namesi
Name:Scamp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1349480 Scamp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 155CytoplasmicSequence analysisAdd BLAST154
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Topological domaini177 – 181LumenalSequence analysis5
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 218CytoplasmicSequence analysisAdd BLAST16
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 261LumenalSequence analysisAdd BLAST22
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 338CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912512 – 338Secretory carrier-associated membrane protein 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei45PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8K021
MaxQBiQ8K021
PaxDbiQ8K021
PRIDEiQ8K021

PTM databases

iPTMnetiQ8K021
PhosphoSitePlusiQ8K021
SwissPalmiQ8K021

Expressioni

Gene expression databases

BgeeiENSMUSG00000021687 Expressed in 282 organ(s), highest expression level in brain
CleanExiMM_SCAMP1
ExpressionAtlasiQ8K021 baseline and differential
GenevisibleiQ8K021 MM

Interactioni

Subunit structurei

Interacts with SYNRG, ITSN1 and SLC9A7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi223555, 2 interactors
IntActiQ8K021, 2 interactors
MINTiQ8K021
STRINGi10090.ENSMUSP00000022197

Structurei

3D structure databases

ProteinModelPortaliQ8K021
SMRiQ8K021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ8K021
KOiK19995
OrthoDBiEOG091G0ID2
PhylomeDBiQ8K021
TreeFamiTF313797

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8K021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDFDSNPFA DPDLNNPFKD PSVTQVTRNV PPGLDEYNPF SDSRTPPPGS
60 70 80 90 100
VKMPNVPNTQ PAIMKPTEEH PAYTQITKEH ALAQAELLKR QEELERKAAE
110 120 130 140 150
LDRREREMQN LSQHGRKNNW PPLPSNFPVG PCFYQDFSVD IPVEFQKTVK
160 170 180 190 200
LMYYLWMFHA VTLFLNIFGC LAWFCVDSSR AVDFGLSILW FLLFTPCSFV
210 220 230 240 250
CWYRPLYGAF RSDSSFRFFV FFFVYICQFA VHVLQAAGFH NWGNCGWISS
260 270 280 290 300
LTGLNKNIPV GIMMIIIAAL FTASAVISLV MFKKVHGLYR TTGASFEKAQ
310 320 330
QEFATGVMSN KTVQTAAANA ASTAATSAAQ NAFKGNQM
Length:338
Mass (Da):38,029
Last modified:October 1, 2002 - v1
Checksum:i7588A06064B23B9D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TSA8Q3TSA8_MOUSE
Secretory carrier-associated membra...
Scamp1
286Annotation score:
D3YTP4D3YTP4_MOUSE
Secretory carrier-associated membra...
Scamp1
116Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034283 mRNA Translation: AAH34283.1
CCDSiCCDS36750.1
RefSeqiNP_083429.1, NM_029153.1
UniGeneiMm.201455

Genome annotation databases

EnsembliENSMUST00000022197; ENSMUSP00000022197; ENSMUSG00000021687
GeneIDi107767
KEGGimmu:107767
UCSCiuc007rlr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034283 mRNA Translation: AAH34283.1
CCDSiCCDS36750.1
RefSeqiNP_083429.1, NM_029153.1
UniGeneiMm.201455

3D structure databases

ProteinModelPortaliQ8K021
SMRiQ8K021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223555, 2 interactors
IntActiQ8K021, 2 interactors
MINTiQ8K021
STRINGi10090.ENSMUSP00000022197

PTM databases

iPTMnetiQ8K021
PhosphoSitePlusiQ8K021
SwissPalmiQ8K021

Proteomic databases

EPDiQ8K021
MaxQBiQ8K021
PaxDbiQ8K021
PRIDEiQ8K021

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022197; ENSMUSP00000022197; ENSMUSG00000021687
GeneIDi107767
KEGGimmu:107767
UCSCiuc007rlr.1 mouse

Organism-specific databases

CTDi9522
MGIiMGI:1349480 Scamp1

Phylogenomic databases

eggNOGiKOG3088 Eukaryota
ENOG410XSJN LUCA
GeneTreeiENSGT00390000014393
HOGENOMiHOG000294221
HOVERGENiHBG071938
InParanoidiQ8K021
KOiK19995
OrthoDBiEOG091G0ID2
PhylomeDBiQ8K021
TreeFamiTF313797

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiScamp1 mouse
PROiPR:Q8K021
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021687 Expressed in 282 organ(s), highest expression level in brain
CleanExiMM_SCAMP1
ExpressionAtlasiQ8K021 baseline and differential
GenevisibleiQ8K021 MM

Family and domain databases

InterProiView protein in InterPro
IPR007273 SCAMP
PANTHERiPTHR10687 PTHR10687, 1 hit
PfamiView protein in Pfam
PF04144 SCAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCAM1_MOUSE
AccessioniPrimary (citable) accession number: Q8K021
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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