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UniProtKB - Q8K013 (GTPBA_MOUSE)
Protein
GTP-binding protein 10
Gene
Gtpbp10
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in the ribosome maturation process.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 155 – 162 | GTPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 202 – 206 | GTPPROSITE-ProRule annotation | 5 | |
Nucleotide bindingi | 278 – 281 | GTPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- GTPase activity Source: InterPro
- GTP binding Source: GO_Central
- magnesium ion binding Source: InterPro
GO - Biological processi
- ribosome biogenesis Source: UniProtKB-KW
Keywordsi
Biological process | Ribosome biogenesis |
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: GTP-binding protein 10 |
Gene namesi | Name:Gtpbp10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385599, Gtpbp10 |
VEuPathDBi | HostDB:ENSMUSG00000040464 |
Subcellular locationi
Nucleus
Note: Found in the dense fibrillar compartment region of the nucleolus.By similarity
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleolus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312631 | 1 – 366 | GTP-binding protein 10Add BLAST | 366 |
Proteomic databases
EPDi | Q8K013 |
MaxQBi | Q8K013 |
PaxDbi | Q8K013 |
PRIDEi | Q8K013 |
ProteomicsDBi | 270903 |
PTM databases
iPTMneti | Q8K013 |
PhosphoSitePlusi | Q8K013 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040464, Expressed in metanephros and 255 other tissues |
Genevisiblei | Q8K013, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 228915, 1 interactor |
STRINGi | 10090.ENSMUSP00000111101 |
Miscellaneous databases
RNActi | Q8K013, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 148 | ObgPROSITE-ProRule annotationAdd BLAST | 136 | |
Domaini | 149 – 344 | OBG-type GPROSITE-ProRule annotationAdd BLAST | 196 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 346 – 366 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG1489, Eukaryota |
GeneTreei | ENSGT00940000155589 |
InParanoidi | Q8K013 |
OMAi | VFMVDIF |
OrthoDBi | 1150635at2759 |
PhylomeDBi | Q8K013 |
TreeFami | TF314774 |
Family and domain databases
CDDi | cd01898, Obg, 1 hit |
Gene3Di | 2.70.210.12, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031167, G_OBG IPR006073, GTP-bd IPR014100, GTP-bd_Obg/CgtA IPR006169, GTP1_OBG_dom IPR036726, GTP1_OBG_dom_sf IPR045086, OBG_GTPase IPR027417, P-loop_NTPase |
PANTHERi | PTHR11702, PTHR11702, 2 hits |
Pfami | View protein in Pfam PF01018, GTP1_OBG, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF002401, GTP_bd_Obg/CgtA, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF82051, SSF82051, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS51883, OBG, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q8K013-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRCGCALLR KYGNFIDNLR IFTKGGSGGM GYPRLGGEGG RGGDVWVVAH
60 70 80 90 100
KNMTLKQLKN KYPQKRFVAG GGANSRVSAL QGSKGKDCEV PAPVGISVTD
110 120 130 140 150
ENGQVLGELN KEEDRVLVAK GGLGGKLHTN FLPLKGQKRI VHLDLKVIAD
160 170 180 190 200
VGLVGFPNAG KSSLLSRVSH ATPVIADYAF TTLRPELGKI MYNDFKQISV
210 220 230 240 250
ADLPGLIEGA HMNKGMGHKF LKHLERTRQL LFVVDISGFQ LSSVTPYRTA
260 270 280 290 300
FETIILLTKE LELYKEELQT KPALLAINKM DLPDAQVKLQ ELMKQLLSPE
310 320 330 340 350
DFLHLFETKM IPEKALEFQH IVPISTVTGE GIAELKSCIR KALDEQDGKE
360
SDAHRSKQLL NLQSSS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WHJ2 | F8WHJ2_MOUSE | GTP-binding protein 10 | Gtpbp10 | 287 | Annotation score: | ||
D3Z4U2 | D3Z4U2_MOUSE | GTP-binding protein 10 | Gtpbp10 | 241 | Annotation score: | ||
F6TIN5 | F6TIN5_MOUSE | GTP-binding protein 10 | Gtpbp10 | 116 | Annotation score: | ||
D6RCG6 | D6RCG6_MOUSE | GTP-binding protein 10 | Gtpbp10 | 76 | Annotation score: | ||
F6WSS0 | F6WSS0_MOUSE | GTP-binding protein 10 | Gtpbp10 | 78 | Annotation score: | ||
A0A0G2JF32 | A0A0G2JF32_MOUSE | GTP-binding protein 10 | Gtpbp10 | 44 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK139595 mRNA Translation: BAE24078.1 BC034507 mRNA Translation: AAH34507.1 |
CCDSi | CCDS39006.1 |
RefSeqi | NP_694756.1, NM_153116.1 |
Genome annotation databases
Ensembli | ENSMUST00000115441; ENSMUSP00000111101; ENSMUSG00000040464 |
GeneIDi | 207704 |
KEGGi | mmu:207704 |
UCSCi | uc008wis.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK139595 mRNA Translation: BAE24078.1 BC034507 mRNA Translation: AAH34507.1 |
CCDSi | CCDS39006.1 |
RefSeqi | NP_694756.1, NM_153116.1 |
3D structure databases
AlphaFoldDBi | Q8K013 |
SMRi | Q8K013 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228915, 1 interactor |
STRINGi | 10090.ENSMUSP00000111101 |
PTM databases
iPTMneti | Q8K013 |
PhosphoSitePlusi | Q8K013 |
Proteomic databases
EPDi | Q8K013 |
MaxQBi | Q8K013 |
PaxDbi | Q8K013 |
PRIDEi | Q8K013 |
ProteomicsDBi | 270903 |
Protocols and materials databases
Antibodypediai | 15416, 155 antibodies from 21 providers |
Genome annotation databases
Ensembli | ENSMUST00000115441; ENSMUSP00000111101; ENSMUSG00000040464 |
GeneIDi | 207704 |
KEGGi | mmu:207704 |
UCSCi | uc008wis.1, mouse |
Organism-specific databases
CTDi | 85865 |
MGIi | MGI:2385599, Gtpbp10 |
VEuPathDBi | HostDB:ENSMUSG00000040464 |
Phylogenomic databases
eggNOGi | KOG1489, Eukaryota |
GeneTreei | ENSGT00940000155589 |
InParanoidi | Q8K013 |
OMAi | VFMVDIF |
OrthoDBi | 1150635at2759 |
PhylomeDBi | Q8K013 |
TreeFami | TF314774 |
Miscellaneous databases
BioGRID-ORCSi | 207704, 2 hits in 74 CRISPR screens |
ChiTaRSi | Gtpbp10, mouse |
PROi | PR:Q8K013 |
RNActi | Q8K013, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040464, Expressed in metanephros and 255 other tissues |
Genevisiblei | Q8K013, MM |
Family and domain databases
CDDi | cd01898, Obg, 1 hit |
Gene3Di | 2.70.210.12, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR031167, G_OBG IPR006073, GTP-bd IPR014100, GTP-bd_Obg/CgtA IPR006169, GTP1_OBG_dom IPR036726, GTP1_OBG_dom_sf IPR045086, OBG_GTPase IPR027417, P-loop_NTPase |
PANTHERi | PTHR11702, PTHR11702, 2 hits |
Pfami | View protein in Pfam PF01018, GTP1_OBG, 1 hit PF01926, MMR_HSR1, 1 hit |
PIRSFi | PIRSF002401, GTP_bd_Obg/CgtA, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF82051, SSF82051, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS51883, OBG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTPBA_MOUSE | |
Accessioni | Q8K013Primary (citable) accession number: Q8K013 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families