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Protein

Mitochondrial ribonuclease P catalytic subunit

Gene

Kiaa0391

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends.By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 Mg2+ or Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi345ZincBy similarity1
Metal bindingi348ZincBy similarity1
Metal bindingi406Magnesium or manganese 1; catalyticBy similarity1
Metal bindingi475Magnesium or manganese 1; catalyticBy similarity1
Metal bindingi476Magnesium or manganese 2; catalyticBy similarity1
Metal bindingi496Magnesium or manganese 2; catalyticBy similarity1
Metal bindingi554Zinc; via tele nitrogenBy similarity1
Metal bindingi575ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processtRNA processing
LigandMagnesium, Manganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ribonuclease P catalytic subunitBy similarity (EC:3.1.26.5By similarity)
Alternative name(s):
Mitochondrial ribonuclease P protein 3By similarity
Short name:
Mitochondrial RNase P protein 3By similarity
Gene namesi
Name:Kiaa0391
Synonyms:Mrpp3By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913382 1110008L16Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43MitochondrionSequence analysisAdd BLAST43
ChainiPRO_000036039744 – 584Mitochondrial ribonuclease P catalytic subunitAdd BLAST541

Post-translational modificationi

Degraded by LONP1 following mitochondrial unfolded protein response, probably leading to inhibit translation in mitochondrion.By similarity

Proteomic databases

EPDiQ8JZY4
MaxQBiQ8JZY4
PaxDbiQ8JZY4
PeptideAtlasiQ8JZY4
PRIDEiQ8JZY4

PTM databases

PhosphoSitePlusiQ8JZY4

Expressioni

Gene expression databases

BgeeiENSMUSG00000021023
ExpressionAtlasiQ8JZY4 baseline and differential
GenevisibleiQ8JZY4 MM

Interactioni

Subunit structurei

Catalytic component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP31.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021411

Structurei

3D structure databases

ProteinModelPortaliQ8JZY4
SMRiQ8JZY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini339 – 575PRORPAdd BLAST237

Domaini

Displays a distorted and non-productive active site that probably switches to a fully productive state only upon association with TRMT10C/MRPP1, HSD17B10/MRPP2 and pre-tRNA substrate.By similarity

Sequence similaritiesi

Belongs to the PPR family. P subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IE4T Eukaryota
ENOG4111GT9 LUCA
GeneTreeiENSGT00390000002201
HOGENOMiHOG000294131
HOVERGENiHBG099441
InParanoidiQ8JZY4
KOiK17655
OMAiHDDPFLL
OrthoDBiEOG091G0JTR
PhylomeDBiQ8JZY4
TreeFamiTF324726

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033495 MRPP3
IPR031595 PRORP_C
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13547:SF1 PTHR13547:SF1, 1 hit
PfamiView protein in Pfam
PF16953 PRORP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFYLSGFRS IPKLWKSNPY FELGPATSST PFFLCAIGNQ QRWFSVKPTT
60 70 80 90 100
PPNSKALNLL DTKARTHRKG NDNNGQVSSD PHYFAAGAAK KRSHIGANPQ
110 120 130 140 150
NQGHALPVRS SVQLPTKPLN SAEWDKLKED FKGKASFEDF IISQMARNCC
160 170 180 190 200
SVDVAKSLLA WVAAKNNGIV GYNLLVKYLY LCVFHKQTSE VIDVYEIMKA
210 220 230 240 250
KYKSLESGGY TLLIRGLIHS DRWRESLLLL EDIKKVMVPS KKNYGDCIQG
260 270 280 290 300
ALLHQDVNTA WNLYQELIGH NLIPPLETLK AFFDYGKDIN DDHYSDKLLD
310 320 330 340 350
ILLYLRNNQL YPGESFAHSI KTWFESIPGR QWKGQFTTIQ KSGQCSGCGR
360 370 380 390 400
TIEPIHLSPE EYEFLKEKIM RDVIDGGDQY KKTTPQELKR FESFVNSCPP
410 420 430 440 450
FDIVIDGLNV AKMFPKGRES QNLLGVVSQL AQQNLQLLVL GRKHMLRPSS
460 470 480 490 500
QWRKEEMEQV RKQAHCFFAD NISEDDPFLL YATLNSGNHC KFITKDLLRD
510 520 530 540 550
HKACLPDART QRLFFKWQQG HQLAIMKGFQ KSKLTFQHIL SYDTVVQRTG
560 570 580
DSWHIPYDED LVQRSSCEVP TKWLCLQRKT PDPC
Length:584
Mass (Da):66,857
Last modified:October 1, 2002 - v1
Checksum:iBB68EF585649A3BD
GO

Sequence cautioni

The sequence BAB25874 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32220 differs from that shown. Partial sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430L → V in BAC27278 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003589 mRNA Translation: BAB22879.1
AK008749 mRNA Translation: BAB25874.1 Different initiation.
AK031144 mRNA Translation: BAC27278.1
AK151976 mRNA Translation: BAE30844.1
AK152028 mRNA Translation: BAE30887.1
CH466526 Genomic DNA Translation: EDL36732.1
BC034876 mRNA Translation: AAH34876.1
AK172942 mRNA Translation: BAD32220.1 Sequence problems.
CCDSiCCDS49068.1
RefSeqiNP_079649.1, NM_025373.1
UniGeneiMm.383213

Genome annotation databases

EnsembliENSMUST00000021411; ENSMUSP00000021411; ENSMUSG00000021023
ENSMUST00000184766; ENSMUSP00000139204; ENSMUSG00000021023
GeneIDi66132
KEGGimmu:66132
UCSCiuc007noo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMRPP3_MOUSE
AccessioniPrimary (citable) accession number: Q8JZY4
Secondary accession number(s): Q6A076
, Q8BSN8, Q9CTH1, Q9D7W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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