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Protein

Cdc42 effector protein 2

Gene

Cdc42ep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • GTP-Rho binding Source: MGI
  • opioid peptide activity Source: MGI

GO - Biological processi

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-MMU-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 2
Alternative name(s):
Binder of Rho GTPases 1
Gene namesi
Name:Cdc42ep2
Synonyms:Borg1, Cep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1929744 Cdc42ep2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002126492 – 214Cdc42 effector protein 2Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei137PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8JZX9
PaxDbiQ8JZX9
PRIDEiQ8JZX9

PTM databases

iPTMnetiQ8JZX9
PhosphoSitePlusiQ8JZX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000045664 Expressed in 191 organ(s), highest expression level in intestine
CleanExiMM_CDC42EP2
GenevisibleiQ8JZX9 MM

Interactioni

Subunit structurei

Interacts with CDC42 and RHOQ in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222493, 1 interactor
STRINGi10090.ENSMUSP00000059883

Structurei

3D structure databases

ProteinModelPortaliQ8JZX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 44CRIBPROSITE-ProRule annotationAdd BLAST15

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410IZS0 Eukaryota
ENOG4111X3X LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ8JZX9
OMAiIMDQDLG
OrthoDBiEOG091G0GMP
PhylomeDBiQ8JZX9
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR017363 Cdc42_effector_prot_2
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
PIRSFiPIRSF038036 Cdc42_effector_p2, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8JZX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTKVPIYLK RGSRKGKKEK LRDLLSSDMI SPPLGDFRHT IHIGSGGGDD
60 70 80 90 100
MFGDISFLQG KFHLLPGTAV EEAEEDGSFD LPFQFTRTTT VCGRELPDGL
110 120 130 140 150
SPLLKNAISL PVIGGPQALT LPTAQAPPKP PRLHLESPQP SPQPSPQGAG
160 170 180 190 200
NVDVWRIPEA GSPHNGMSPE PEAEEPFLSH ASSLLSLHVD LGPSILDDVL
210
QIMDHDLGRV QIPT
Length:214
Mass (Da):22,997
Last modified:October 1, 2002 - v1
Checksum:i24AD498747C2A6D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034884 mRNA Translation: AAH34884.1
CCDSiCCDS29484.1
RefSeqiNP_081048.1, NM_026772.2
UniGeneiMm.491103

Genome annotation databases

EnsembliENSMUST00000055458; ENSMUSP00000059883; ENSMUSG00000045664
GeneIDi104252
KEGGimmu:104252
UCSCiuc008gfz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC034884 mRNA Translation: AAH34884.1
CCDSiCCDS29484.1
RefSeqiNP_081048.1, NM_026772.2
UniGeneiMm.491103

3D structure databases

ProteinModelPortaliQ8JZX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222493, 1 interactor
STRINGi10090.ENSMUSP00000059883

PTM databases

iPTMnetiQ8JZX9
PhosphoSitePlusiQ8JZX9

Proteomic databases

MaxQBiQ8JZX9
PaxDbiQ8JZX9
PRIDEiQ8JZX9

Protocols and materials databases

DNASUi104252
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055458; ENSMUSP00000059883; ENSMUSG00000045664
GeneIDi104252
KEGGimmu:104252
UCSCiuc008gfz.2 mouse

Organism-specific databases

CTDi10435
MGIiMGI:1929744 Cdc42ep2

Phylogenomic databases

eggNOGiENOG410IZS0 Eukaryota
ENOG4111X3X LUCA
GeneTreeiENSGT00730000110928
HOGENOMiHOG000233908
HOVERGENiHBG052803
InParanoidiQ8JZX9
OMAiIMDQDLG
OrthoDBiEOG091G0GMP
PhylomeDBiQ8JZX9
TreeFamiTF331725

Enzyme and pathway databases

ReactomeiR-MMU-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

ChiTaRSiCdc42ep2 mouse
PROiPR:Q8JZX9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045664 Expressed in 191 organ(s), highest expression level in intestine
CleanExiMM_CDC42EP2
GenevisibleiQ8JZX9 MM

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR017363 Cdc42_effector_prot_2
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
PIRSFiPIRSF038036 Cdc42_effector_p2, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBORG1_MOUSE
AccessioniPrimary (citable) accession number: Q8JZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 1, 2002
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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